TiF4 Varnish—A 19F-NMR Stability Study and Enamel Reactivity Evaluation

• Published in: Chemical & Pharmaceutical Bulletin Vol. 56; no. 1; pp. 139 - 141
• Main Authors: Nóbrega, Carolina Bezerra Cavalcanti, Fujiwara, Fred Yukio, Cury, Jaime Aparecido, Rosalen, Pedro Luiz
• Format: Journal Article
• Language: English
• Published: Tokyo The Pharmaceutical Society of Japan 01-01-2008; Pharmaceutical Society of Japan; Japan Science and Technology Agency
• Subjects: drug stability; fluoride varnish; titanium tetrafluoride
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.56.139

The aim of this study was to develop a titanium tetrafluoride (TiF4) varnish and evaluate the stability of the formulation and its reactivity with dental enamel. The varnish was prepared in a resinous matrix using ethanol 96% as solvent. Samples (n=45) were aged at 65 °C and 30% of relativity humidity (RE n° 01/05—ANVISA) and after 3, 6, 9 and 12 months, nine samples were removed for evaluation and compared with fresh samples. Chemical stability of TiF4 varnish was determinate by 19F-NMR and the reactivity of the formulation was quantified by formation of fluoride loosely (CaF2) and firmly bound (fluorapatite; FA) to enamel. For reactivity comparisons, a varnish without TiF4 was used as control. The loss of soluble fluoride was about 0.9% after one year of storage. The values of the reactivity (mean±S.D.) of fresh, aged at 3, 6, 9 and 12 months and control samples were: CaF2 (μg F/mm2): 89.3±27.5a; 54.5±14.3b; 51.2±29.8b; 69.3±21.3a; 48.0±27.4b; 0.10±0.07c, FA (μg F/g): 2477.5±1044.0a; 2484.8±992.0a; 2580.0±1383.9a; 2517.2±929.9a; 2121.0±1059.2a; 330.0±180.0b, respectively. Means followed by distinct letters were statistically different (p<0.05). After one year of storage, the formulation was chemically stable and the levels of FA were maintained. However there was an initial decrease in the ability to form CaF2.