Dose-response studies of atracurium, vecuronium and pancuronium in the elderly

Dose-response studies of atracurium, vecuronium and pancuronium in the elderly

Dose-response curves were constructed for atracurium, vecuronium and pancuronium in elderly subjects in order to assess potency of these relaxants. The results were compared to data previously obtained for adult subjects using the same method. A single-dose method of potency determination was used i...

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Bibliographic Details
Published in:Anaesthesia Vol. 44; no. 11; p. 925
Main Authors: Bell, P F, Mirakhur, R K, Clarke, R S
Format: Journal Article
Language:English
Published: England 01-11-1989
Subjects:
Age Factors
Aged
Anesthesia
Atracurium
Dose-Response Relationship, Drug
Humans
Pancuronium
Vecuronium Bromide
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Description
Summary:Dose-response curves were constructed for atracurium, vecuronium and pancuronium in elderly subjects in order to assess potency of these relaxants. The results were compared to data previously obtained for adult subjects using the same method. A single-dose method of potency determination was used in both studies. The results indicate no significant difference in the potency of these relaxants between elderly and adult subjects; the ED95S were 249 and 226 micrograms/kg for atracurium, 43.1 and 39.6 micrograms/kg for vecuronium and 65.9 and 60 micrograms/kg for pancuronium respectively in the elderly and the adults.
ISSN:0003-2409
DOI:10.1111/j.1365-2044.1989.tb09152.x