Influence of sex on susceptibility in the Theiler's murine encephalomyelitis virus model for multiple sclerosis

Multiple sclerosis (MS) is a demyelinating disease in humans which affects females more frequently than males. Theiler's murine encephalomyelitis virus (TMEV) induces demyelination similar to human MS in susceptible strains of mice after intracerebral inoculation. In this paper we report that s...

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Bibliographic Details
Published in:	Journal of neuroimmunology Vol. 29; no. 1-3; p. 15
Main Authors:	Kappel, C A, Melvold, R W, Kim, B S
Format:	Journal Article
Language:	English
Published:	Netherlands 01-09-1990
Subjects:	Animals Demyelinating Diseases - etiology Disease Models, Animal Disease Susceptibility Genotype H-2 Antigens - genetics Maus Elberfeld virus - pathogenicity Mice Mice, Inbred Strains Multiple Sclerosis - etiology Multiple Sclerosis - genetics Sex Factors
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Summary:	Multiple sclerosis (MS) is a demyelinating disease in humans which affects females more frequently than males. Theiler's murine encephalomyelitis virus (TMEV) induces demyelination similar to human MS in susceptible strains of mice after intracerebral inoculation. In this paper we report that sex influences susceptibility to TMEV-induced demyelination in certain genotypes derived from C57L/J and SJL/J or SWR/J mice. This is the first report of an animal model for MS that shows an association between sex and susceptibility, and this information may facilitate the investigation of human MS.
ISSN:	0165-5728
DOI:	10.1016/0165-5728(90)90143-b