Functional and Morphological Outcomes after Trabeculectomy and Deep Sclerectomy-Results from a Monocentric Registry Study
The aim of this study was to compare the effectiveness of trabeculectomy (TE) and deep sclerectomy (DS) in lowering intraocular pressure (IOP) and thereby preserving visual field and peripapillary retinal nerve fiber layer (RNFL) tissue in primary open-angle glaucoma (POAG) cases. IOP, number of IOP...
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Published in: | Diagnostics (Basel) Vol. 14; no. 1; p. 101 |
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Abstract | The aim of this study was to compare the effectiveness of trabeculectomy (TE) and deep sclerectomy (DS) in lowering intraocular pressure (IOP) and thereby preserving visual field and peripapillary retinal nerve fiber layer (RNFL) tissue in primary open-angle glaucoma (POAG) cases. IOP, number of IOP-lowering medications, visual acuity, mean defect of standard automated perimetry, and mean peripapillary RNFL thickness were retrospectively collected and followed up for 3 years after surgery. TE was performed in 104 eyes and DS in 183 eyes. Age, gender, laterality, IOP, number of medications, visual acuity, perimetry mean defect, and peripapillary RNFL thickness were equally distributed at baseline. Mean IOP decreased from 23.8 ± 1.4 mmHg and 23.1 ± 0.4 mmHg to 13.4 ± 0.6 mmHg (
< 0.001) and 15.4 ± 0.7 mmHg (
= 0.001) in the TE and DS groups, respectively. Mean defect remained stable (TE: -11.5 ± 0.9 dB to -12.0 ± 1.1 (
= 0.090); DS: -10.5 ± 0.9 dB to -11.0 ± 1.0 dB (
= 0.302)), while mean peripapillary RNFL thickness showed further deterioration during follow-up (TE group: 64.4 ± 2.1 μm to 59.7 ± 3.5 μm (
< 0.001); DS group: 64.9 ± 1.9 μm to 58.4 ± 2.1 μm (
< 0.001)). Both TE and DS were comparably effective concerning postoperative reduction in IOP and medication. However, glaucoma disease further progressed during follow-up. |
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AbstractList | The aim of this study was to compare the effectiveness of trabeculectomy (TE) and deep sclerectomy (DS) in lowering intraocular pressure (IOP) and thereby preserving visual field and peripapillary retinal nerve fiber layer (RNFL) tissue in primary open-angle glaucoma (POAG) cases. IOP, number of IOP-lowering medications, visual acuity, mean defect of standard automated perimetry, and mean peripapillary RNFL thickness were retrospectively collected and followed up for 3 years after surgery. TE was performed in 104 eyes and DS in 183 eyes. Age, gender, laterality, IOP, number of medications, visual acuity, perimetry mean defect, and peripapillary RNFL thickness were equally distributed at baseline. Mean IOP decreased from 23.8 ± 1.4 mmHg and 23.1 ± 0.4 mmHg to 13.4 ± 0.6 mmHg (p < 0.001) and 15.4 ± 0.7 mmHg (p = 0.001) in the TE and DS groups, respectively. Mean defect remained stable (TE: −11.5 ± 0.9 dB to −12.0 ± 1.1 (p = 0.090); DS: −10.5 ± 0.9 dB to −11.0 ± 1.0 dB (p = 0.302)), while mean peripapillary RNFL thickness showed further deterioration during follow-up (TE group: 64.4 ± 2.1 μm to 59.7 ± 3.5 μm (p < 0.001); DS group: 64.9 ± 1.9 μm to 58.4 ± 2.1 μm (p < 0.001)). Both TE and DS were comparably effective concerning postoperative reduction in IOP and medication. However, glaucoma disease further progressed during follow-up. The aim of this study was to compare the effectiveness of trabeculectomy (TE) and deep sclerectomy (DS) in lowering intraocular pressure (IOP) and thereby preserving visual field and peripapillary retinal nerve fiber layer (RNFL) tissue in primary open-angle glaucoma (POAG) cases. IOP, number of IOP-lowering medications, visual acuity, mean defect of standard automated perimetry, and mean peripapillary RNFL thickness were retrospectively collected and followed up for 3 years after surgery. TE was performed in 104 eyes and DS in 183 eyes. Age, gender, laterality, IOP, number of medications, visual acuity, perimetry mean defect, and peripapillary RNFL thickness were equally distributed at baseline. Mean IOP decreased from 23.8 ± 1.4 mmHg and 23.1 ± 0.4 mmHg to 13.4 ± 0.6 mmHg ( < 0.001) and 15.4 ± 0.7 mmHg ( = 0.001) in the TE and DS groups, respectively. Mean defect remained stable (TE: -11.5 ± 0.9 dB to -12.0 ± 1.1 ( = 0.090); DS: -10.5 ± 0.9 dB to -11.0 ± 1.0 dB ( = 0.302)), while mean peripapillary RNFL thickness showed further deterioration during follow-up (TE group: 64.4 ± 2.1 μm to 59.7 ± 3.5 μm ( < 0.001); DS group: 64.9 ± 1.9 μm to 58.4 ± 2.1 μm ( < 0.001)). Both TE and DS were comparably effective concerning postoperative reduction in IOP and medication. However, glaucoma disease further progressed during follow-up. The aim of this study was to compare the effectiveness of trabeculectomy (TE) and deep sclerectomy (DS) in lowering intraocular pressure (IOP) and thereby preserving visual field and peripapillary retinal nerve fiber layer (RNFL) tissue in primary open-angle glaucoma (POAG) cases. IOP, number of IOP-lowering medications, visual acuity, mean defect of standard automated perimetry, and mean peripapillary RNFL thickness were retrospectively collected and followed up for 3 years after surgery. TE was performed in 104 eyes and DS in 183 eyes. Age, gender, laterality, IOP, number of medications, visual acuity, perimetry mean defect, and peripapillary RNFL thickness were equally distributed at baseline. Mean IOP decreased from 23.8 ± 1.4 mmHg and 23.1 ± 0.4 mmHg to 13.4 ± 0.6 mmHg ( p < 0.001) and 15.4 ± 0.7 mmHg ( p = 0.001) in the TE and DS groups, respectively. Mean defect remained stable (TE: −11.5 ± 0.9 dB to −12.0 ± 1.1 ( p = 0.090); DS: −10.5 ± 0.9 dB to −11.0 ± 1.0 dB ( p = 0.302)), while mean peripapillary RNFL thickness showed further deterioration during follow-up (TE group: 64.4 ± 2.1 μm to 59.7 ± 3.5 μm ( p < 0.001); DS group: 64.9 ± 1.9 μm to 58.4 ± 2.1 μm ( p < 0.001)). Both TE and DS were comparably effective concerning postoperative reduction in IOP and medication. However, glaucoma disease further progressed during follow-up. The aim of this study was to compare the effectiveness of trabeculectomy (TE) and deep sclerectomy (DS) in lowering intraocular pressure (IOP) and thereby preserving visual field and peripapillary retinal nerve fiber layer (RNFL) tissue in primary open-angle glaucoma (POAG) cases. IOP, number of IOP-lowering medications, visual acuity, mean defect of standard automated perimetry, and mean peripapillary RNFL thickness were retrospectively collected and followed up for 3 years after surgery. TE was performed in 104 eyes and DS in 183 eyes. Age, gender, laterality, IOP, number of medications, visual acuity, perimetry mean defect, and peripapillary RNFL thickness were equally distributed at baseline. Mean IOP decreased from 23.8 ± 1.4 mmHg and 23.1 ± 0.4 mmHg to 13.4 ± 0.6 mmHg (p < 0.001) and 15.4 ± 0.7 mmHg (p = 0.001) in the TE and DS groups, respectively. Mean defect remained stable (TE: -11.5 ± 0.9 dB to -12.0 ± 1.1 (p = 0.090); DS: -10.5 ± 0.9 dB to -11.0 ± 1.0 dB (p = 0.302)), while mean peripapillary RNFL thickness showed further deterioration during follow-up (TE group: 64.4 ± 2.1 μm to 59.7 ± 3.5 μm (p < 0.001); DS group: 64.9 ± 1.9 μm to 58.4 ± 2.1 μm (p < 0.001)). Both TE and DS were comparably effective concerning postoperative reduction in IOP and medication. However, glaucoma disease further progressed during follow-up.The aim of this study was to compare the effectiveness of trabeculectomy (TE) and deep sclerectomy (DS) in lowering intraocular pressure (IOP) and thereby preserving visual field and peripapillary retinal nerve fiber layer (RNFL) tissue in primary open-angle glaucoma (POAG) cases. IOP, number of IOP-lowering medications, visual acuity, mean defect of standard automated perimetry, and mean peripapillary RNFL thickness were retrospectively collected and followed up for 3 years after surgery. TE was performed in 104 eyes and DS in 183 eyes. Age, gender, laterality, IOP, number of medications, visual acuity, perimetry mean defect, and peripapillary RNFL thickness were equally distributed at baseline. Mean IOP decreased from 23.8 ± 1.4 mmHg and 23.1 ± 0.4 mmHg to 13.4 ± 0.6 mmHg (p < 0.001) and 15.4 ± 0.7 mmHg (p = 0.001) in the TE and DS groups, respectively. Mean defect remained stable (TE: -11.5 ± 0.9 dB to -12.0 ± 1.1 (p = 0.090); DS: -10.5 ± 0.9 dB to -11.0 ± 1.0 dB (p = 0.302)), while mean peripapillary RNFL thickness showed further deterioration during follow-up (TE group: 64.4 ± 2.1 μm to 59.7 ± 3.5 μm (p < 0.001); DS group: 64.9 ± 1.9 μm to 58.4 ± 2.1 μm (p < 0.001)). Both TE and DS were comparably effective concerning postoperative reduction in IOP and medication. However, glaucoma disease further progressed during follow-up. |
Author | Gubser, Pascal Aurel Häner, Nathanael Urs Pfeiffer, Valentin Lincke, Joel-Benjamin Shang, Xiao Zinkernagel, Martin Sebastian Unterlauft, Jan Darius |
AuthorAffiliation | University Eye Hospital, Inselspital, University of Bern, Freiburgstrasse 18, 3010 Bern, Switzerland; valentin.pfeiffer@insel.ch (V.P.); pascal.gubser@students.unibe.ch (P.A.G.); xiao.shang@students.unibe.ch (X.S.); joel-benjamin.lincke@insel.ch (J.-B.L.); nathanael.haener@insel.ch (N.U.H.); martin.zinkernagel@insel.ch (M.S.Z.) |
AuthorAffiliation_xml | – name: University Eye Hospital, Inselspital, University of Bern, Freiburgstrasse 18, 3010 Bern, Switzerland; valentin.pfeiffer@insel.ch (V.P.); pascal.gubser@students.unibe.ch (P.A.G.); xiao.shang@students.unibe.ch (X.S.); joel-benjamin.lincke@insel.ch (J.-B.L.); nathanael.haener@insel.ch (N.U.H.); martin.zinkernagel@insel.ch (M.S.Z.) |
Author_xml | – sequence: 1 givenname: Valentin surname: Pfeiffer fullname: Pfeiffer, Valentin organization: University Eye Hospital, Inselspital, University of Bern, Freiburgstrasse 18, 3010 Bern, Switzerland – sequence: 2 givenname: Pascal Aurel surname: Gubser fullname: Gubser, Pascal Aurel organization: University Eye Hospital, Inselspital, University of Bern, Freiburgstrasse 18, 3010 Bern, Switzerland – sequence: 3 givenname: Xiao surname: Shang fullname: Shang, Xiao organization: University Eye Hospital, Inselspital, University of Bern, Freiburgstrasse 18, 3010 Bern, Switzerland – sequence: 4 givenname: Joel-Benjamin surname: Lincke fullname: Lincke, Joel-Benjamin organization: University Eye Hospital, Inselspital, University of Bern, Freiburgstrasse 18, 3010 Bern, Switzerland – sequence: 5 givenname: Nathanael Urs surname: Häner fullname: Häner, Nathanael Urs organization: University Eye Hospital, Inselspital, University of Bern, Freiburgstrasse 18, 3010 Bern, Switzerland – sequence: 6 givenname: Martin Sebastian surname: Zinkernagel fullname: Zinkernagel, Martin Sebastian organization: University Eye Hospital, Inselspital, University of Bern, Freiburgstrasse 18, 3010 Bern, Switzerland – sequence: 7 givenname: Jan Darius surname: Unterlauft fullname: Unterlauft, Jan Darius organization: University Eye Hospital, Inselspital, University of Bern, Freiburgstrasse 18, 3010 Bern, Switzerland |
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Cites_doi | 10.1177/112067210401400105 10.1097/IJG.0b013e318182ed9e 10.1016/0002-9394(68)91288-9 10.1016/j.ophtha.2011.01.047 10.1016/j.ophtha.2011.09.043 10.1007/s10792-021-01840-y 10.1016/S0886-3350(01)01032-X 10.1038/eye.2001.152 10.1038/eye.2001.60 10.1038/sj.eye.6701403 10.1001/jamaophthalmol.2013.5059 10.1146/annurev-vision-100419-111350 10.1159/000458483 10.1016/j.survophthal.2008.08.023 10.1159/000458484 10.1111/j.1442-9071.2008.01896.x 10.1016/j.ophtha.2022.07.004 10.1016/j.ophtha.2013.07.049 10.1177/112067210801800515 10.1007/s00417-021-05144-w 10.1001/archopht.120.10.1268 10.1016/S0161-6420(00)00263-3 10.1016/j.ophtha.2017.05.014 10.1159/000086112 10.3390/jcm11195840 10.1038/s41598-020-59792-9 10.1016/S0002-9394(00)00538-9 10.1016/S0140-6736(14)62111-5 10.1016/S0140-6736(23)01289-8 10.1001/jama.2020.21899 10.1016/S0161-6420(97)30174-2 |
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Keywords | glaucoma surgery glaucoma optical coherence tomography (OCT) visual field trabeculectomy perimetry deep sclerectomy |
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SubjectTerms | deep sclerectomy Glaucoma glaucoma surgery Intervention Medical treatment optical coherence tomography (OCT) Patients Statistical analysis Success Surgeons Surgery Surgical techniques Sutures trabeculectomy visual field |
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Title | Functional and Morphological Outcomes after Trabeculectomy and Deep Sclerectomy-Results from a Monocentric Registry Study |
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