Hydrocortisone nanosuspensions for ophthalmic delivery: A comparative study between microfluidic nanoprecipitation and wet milling

Recently, drug nanosuspensions have shown a potential for ophthalmic delivery. In this study, a hydrocortisone (HC) nanosuspension (NS) was developed using microfluidic nanoprecipitation as a recent, simple and cost-effective bottom-up technique of drug nanonization. For comparison, a second HC NS w...

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Bibliographic Details
Published in:	Journal of controlled release Vol. 149; no. 2; pp. 175 - 181
Main Authors:	Ali, Hany S.M., York, Peter, Ali, Ahmed M.A., Blagden, Nicholas
Format:	Journal Article
Language:	English
Published:	Kidlington Elsevier B.V 20-01-2011 Elsevier
Subjects:	Animals bioavailability Biological and medical sciences Biological Availability Chemical Precipitation Controlled release cortisol cost effectiveness crystal structure differential scanning calorimetry Drug Carriers - chemistry Drug Compounding - methods drugs Eye - metabolism General pharmacology Hydrocortisone Hydrocortisone - administration & dosage Hydrocortisone - pharmacokinetics Male Medical sciences Microfluidics Milling Nanostructures - chemistry Nanosuspension Nanotechnology - methods Ophthalmic delivery Ophthalmic Solutions Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Rabbits Solutions Suspensions temperature wet milling Wettability X-ray diffraction zeta potential Nanosuspension Hydrocortisone Ophthalmic delivery Controlled release Microfluidics Milling Corticosteroid Pharmaceutical technology Steroid hormone Controlled release form Control release polymer Antiinflammatory agent Grinding(comminution) Ophthalmic preparation Adrenal hormone Dosage form Comparative study Nanotechnology
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