Helicobacter Pylori Detection and Clinical Symptomatology of Gastroesophageal Reflux Disease in Pediatric Patients with Otitis Media with Effusion

• Published in: International journal of pediatric otorhinolaryngology Vol. 87; pp. 126 - 129
• Main Authors: Boronat-Echeverría, Nuria, Aguirre-Mariscal, Héctor, Carmolinga-Ponce, Margarita, Sevilla-Delgado, Yolanda, Miceli-Flores, Ricardo, Kennedy-Padilla, Aisha, Mejía-Aranguré, Juan Manuel, Dr
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01-08-2016
• Subjects: Adolescent; Child; Child, Preschool; Chronic Disease; Cohort Studies; Effusion; ELISA; Enzyme-Linked Immunosorbent Assay; Exudates and Transudates - microbiology; Female; Gastroesophageal reflux; Gastroesophageal Reflux - epidemiology; Helicobacter Infections - epidemiology; Helicobacter pyllori; Helicobacter pylori; Helicobacter pylori - genetics; Helicobacter pylori - metabolism; Humans; Infant; Male; Mexico - epidemiology; Middle Ear Ventilation; Otitis media; Otitis Media with Effusion - epidemiology; Otitis Media with Effusion - microbiology; Otitis Media with Effusion - surgery; Otolaryngology; PCR; Pediatrics; Polymerase Chain Reaction; Prospective Studies; H. pyllori; Otitis media; effusion; gastroesophageal reflux; PCR; ELISA; Gastroesophageal reflux; Helicobacter pyllori; Effusion
• ISSN: 0165-5876; 1872-8464
• DOI: 10.1016/j.ijporl.2016.06.023

Abstract Objectives The study aimed to demonstrate H. pylori presence in otitis media with effusion (OME) and its association with symtomatology of gastroesophageal reflux disease (GERD). Methods In a cohort study, 69 effusions were collected during tympanostomy tube insertion for H. pylori detection using PCR and ELISA. Validated questionnaires were performed according to age for clinical diagnosis of GERD; chi-square x2 statistical analysis was made. Results Eight of the 69 ear effusions (5.7%) were positive for H. pylori detection using ELISA. Two patients (2.9%) had positive results for H. pylori detection using ELISA and PCR. These eight patients had positive results too in GERD questionnaires. None of the patients with negative/suspect questionnaires had positive results for H. pylori. We found statistical association between the results of ELISA, PCR and questionnaires (x2, p=0.001). Conclusions The H. pylori presence in effusions varies widely, in our population the frequency was lower than other reports. We found strong association between H.pylori in effusions and positive GERD questionnaires. The bacterium role in OME chronicity is not clear, but this study supports the GERD participation in OME pathogenesis.