Circulating MicroRNAs and Extracellular Vesicle-Derived MicroRNAs as Predictors of Functional Recovery in Ischemic Stroke Patients: A Systematic Review and Meta-Analysis
Stroke accounts for the second leading cause of death and a major cause of disability, with limited therapeutic strategy in both the acute and chronic phases. Blood-based biomarkers are intensively researched and widely recognized as useful tools to predict the prognoses of patients confronted with...
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| Published in: | International journal of molecular sciences Vol. 24; no. 1; p. 251 |
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| Main Authors: | , , , , , , , |
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| Abstract | Stroke accounts for the second leading cause of death and a major cause of disability, with limited therapeutic strategy in both the acute and chronic phases. Blood-based biomarkers are intensively researched and widely recognized as useful tools to predict the prognoses of patients confronted with therapeutically limited diseases. We performed a systematic review of the circulating biomarkers in IS patients with prognostic value, with a focus on microRNAs and exosomes as predictive biomarkers of motor and cognitive recovery. We identified 63 studies, totalizing 72 circulating biomarkers with prognostic value in stroke recovery, as follows: 68 miRNAs and exosomal-miRNAs being identified as predictive for motor recovery after stroke, and seven biomarkers being predictive for cognitive recovery. Twelve meta-analyses were performed using effect sizes (random-effects and fixed-effects model). The most significant correlation findings obtained after pooling were with miR-21, miR-29b, miR-125b-5p, miR-126, and miR-335. We identified several miRNAs that were correlated with clinical outcomes of stroke severity and recovery after ischemic stroke, providing predictive information on motor and cognitive recovery. Based on the current state of research, we identified serum miR-9 and neutrophil miR-29b as the most promising biomarkers for in-depth follow-up studies, followed by serum miR-124 and plasma miR-125b. |
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| AbstractList | Stroke accounts for the second leading cause of death and a major cause of disability, with limited therapeutic strategy in both the acute and chronic phases. Blood-based biomarkers are intensively researched and widely recognized as useful tools to predict the prognoses of patients confronted with therapeutically limited diseases. We performed a systematic review of the circulating biomarkers in IS patients with prognostic value, with a focus on microRNAs and exosomes as predictive biomarkers of motor and cognitive recovery. We identified 63 studies, totalizing 72 circulating biomarkers with prognostic value in stroke recovery, as follows: 68 miRNAs and exosomal-miRNAs being identified as predictive for motor recovery after stroke, and seven biomarkers being predictive for cognitive recovery. Twelve meta-analyses were performed using effect sizes (random-effects and fixed-effects model). The most significant correlation findings obtained after pooling were with miR-21, miR-29b, miR-125b-5p, miR-126, and miR-335. We identified several miRNAs that were correlated with clinical outcomes of stroke severity and recovery after ischemic stroke, providing predictive information on motor and cognitive recovery. Based on the current state of research, we identified serum miR-9 and neutrophil miR-29b as the most promising biomarkers for in-depth follow-up studies, followed by serum miR-124 and plasma miR-125b. Stroke accounts for the second leading cause of death and a major cause of disability, with limited therapeutic strategy in both the acute and chronic phases. Blood-based biomarkers are intensively researched and widely recognized as useful tools to predict the prognoses of patients confronted with therapeutically limited diseases. We performed a systematic review of the circulating biomarkers in IS patients with prognostic value, with a focus on microRNAs and exosomes as predictive biomarkers of motor and cognitive recovery. We identified 63 studies, totalizing 72 circulating biomarkers with prognostic value in stroke recovery, as follows: 68 miRNAs and exosomal-miRNAs being identified as predictive for motor recovery after stroke, and seven biomarkers being predictive for cognitive recovery. Twelve meta-analyses were performed using effect sizes (random-effects and fixed-effects model). The most significant correlation findings obtained after pooling were with miR-21, miR-29b, miR-125b-5p, miR-126, and miR-335. We identified several miRNAs that were correlated with clinical outcomes of stroke severity and recovery after ischemic stroke, providing predictive information on motor and cognitive recovery. Based on the current state of research, we identified serum miR-9 and neutrophil miR-29b as the most promising biomarkers for in-depth follow-up studies, followed by serum miR-124 and plasma miR-125b.Stroke accounts for the second leading cause of death and a major cause of disability, with limited therapeutic strategy in both the acute and chronic phases. Blood-based biomarkers are intensively researched and widely recognized as useful tools to predict the prognoses of patients confronted with therapeutically limited diseases. We performed a systematic review of the circulating biomarkers in IS patients with prognostic value, with a focus on microRNAs and exosomes as predictive biomarkers of motor and cognitive recovery. We identified 63 studies, totalizing 72 circulating biomarkers with prognostic value in stroke recovery, as follows: 68 miRNAs and exosomal-miRNAs being identified as predictive for motor recovery after stroke, and seven biomarkers being predictive for cognitive recovery. Twelve meta-analyses were performed using effect sizes (random-effects and fixed-effects model). The most significant correlation findings obtained after pooling were with miR-21, miR-29b, miR-125b-5p, miR-126, and miR-335. We identified several miRNAs that were correlated with clinical outcomes of stroke severity and recovery after ischemic stroke, providing predictive information on motor and cognitive recovery. Based on the current state of research, we identified serum miR-9 and neutrophil miR-29b as the most promising biomarkers for in-depth follow-up studies, followed by serum miR-124 and plasma miR-125b. |
| Author | Popa-Wagner, Aurel Badulescu, Andrei-Vlad Ciobanu, Daniela Burlacu, Codrin-Constantin Chelaru, Vlad-Florin Mitre, Andrei-Otto Capitanescu, Bogdan Hermann, Dirk M |
| AuthorAffiliation | 3 Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania 1 Chair of Vascular Neurology, Dementia and Ageing, University Hospital Essen, University of Duisburg—Essen, 45147 Essen, Germany 4 Department of Pathophysiology, Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, Victor Babeş Street, No. 2-4, 400012 Cluj-Napoca, Romania 2 Department of Internal Medicine, University of Medicine and Pharmacia Craiova, 200349 Craiova, Romania |
| AuthorAffiliation_xml | – name: 2 Department of Internal Medicine, University of Medicine and Pharmacia Craiova, 200349 Craiova, Romania – name: 4 Department of Pathophysiology, Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, Victor Babeş Street, No. 2-4, 400012 Cluj-Napoca, Romania – name: 1 Chair of Vascular Neurology, Dementia and Ageing, University Hospital Essen, University of Duisburg—Essen, 45147 Essen, Germany – name: 3 Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania |
| Author_xml | – sequence: 1 givenname: Codrin-Constantin orcidid: 0000-0002-2017-3086 surname: Burlacu fullname: Burlacu, Codrin-Constantin organization: Chair of Vascular Neurology, Dementia and Ageing, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany – sequence: 2 givenname: Daniela orcidid: 0000-0003-0225-0401 surname: Ciobanu fullname: Ciobanu, Daniela organization: Department of Internal Medicine, University of Medicine and Pharmacia Craiova, 200349 Craiova, Romania – sequence: 3 givenname: Andrei-Vlad orcidid: 0000-0002-2035-8339 surname: Badulescu fullname: Badulescu, Andrei-Vlad organization: Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania – sequence: 4 givenname: Vlad-Florin orcidid: 0000-0003-2954-3263 surname: Chelaru fullname: Chelaru, Vlad-Florin organization: Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania – sequence: 5 givenname: Andrei-Otto surname: Mitre fullname: Mitre, Andrei-Otto organization: Department of Pathophysiology, Iuliu Haţieganu University of Medicine and Pharmacy Cluj-Napoca, Victor Babeş Street, No. 2-4, 400012 Cluj-Napoca, Romania – sequence: 6 givenname: Bogdan surname: Capitanescu fullname: Capitanescu, Bogdan organization: Department of Internal Medicine, University of Medicine and Pharmacia Craiova, 200349 Craiova, Romania – sequence: 7 givenname: Dirk M surname: Hermann fullname: Hermann, Dirk M organization: Chair of Vascular Neurology, Dementia and Ageing, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany – sequence: 8 givenname: Aurel orcidid: 0000-0003-4574-8605 surname: Popa-Wagner fullname: Popa-Wagner, Aurel organization: Department of Internal Medicine, University of Medicine and Pharmacia Craiova, 200349 Craiova, Romania |
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| Keywords | microRNAs stroke recovery extracellular vesicles disease biomarkers prognosis ischemic stroke |
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| SubjectTerms | Biomarkers Circulating MicroRNA disease biomarkers Exosomes - genetics extracellular vesicles Humans ischemic stroke Ischemic Stroke - genetics microRNAs MicroRNAs - genetics prognosis Review Stroke - genetics Stroke - therapy stroke recovery |
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| Title | Circulating MicroRNAs and Extracellular Vesicle-Derived MicroRNAs as Predictors of Functional Recovery in Ischemic Stroke Patients: A Systematic Review and Meta-Analysis |
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