Bionanocomposites containing magnetic graphite as potential systems for drug delivery

• Published in: International journal of pharmaceutics Vol. 477; no. 1-2; pp. 553 - 563
• Main Authors: Ribeiro, Lígia N.M., Alcântara, Ana C.S., Darder, Margarita, Aranda, Pilar, Herrmann, Paulo S.P., Araújo-Moreira, Fernando M., García-Hernández, Mar, Ruiz-Hitzky, Eduardo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 30-12-2014
• Subjects: Alginate; Alginates - chemistry; Bionanocomposites; Controlled release; Drug Carriers - chemistry; Drug Compounding; Drug delivery; Drug Liberation; Glucuronic Acid - chemistry; Graphite - chemistry; Hexuronic Acids - chemistry; Hydroxides - administration & dosage; Hydroxides - chemistry; Ibuprofen; Ibuprofen - administration & dosage; Ibuprofen - chemistry; Layered double hydroxides; Magnetic graphite; Magnetite Nanoparticles - chemistry; Microscopy, Electron, Scanning; Nanocomposites - chemistry; Particle Size; Spectroscopy, Fourier Transform Infrared; Stress, Mechanical; Surface Properties; Bionanocomposites; Ibuprofen; Drug delivery; Alginate; Magnetic graphite; Controlled release; Layered double hydroxides
• ISSN: 0378-5173; 1873-3476
• DOI: 10.1016/j.ijpharm.2014.10.033

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New magnetic bio-hybrid matrices for potential application in drug delivery are developed from the assembly of the biopolymer alginate and magnetic graphite nanoparticles. Ibuprofen (IBU) intercalated in a Mg–Al layered double hydroxide (LDH) was chosen as a model drug delivery system (DDS) to be incorporated as third component of the magnetic bionanocomposite DDS. For comparative purposes DDS based on the incorporation of pure IBU in the magnetic bio-hybrid matrices were also studied. All the resulting magnetic bionanocomposites were processed as beads and films and characterized by different techniques with the aim to elucidate the role of the magnetic graphite on the systems, as well as that of the inorganic brucite-like layers in the drug-loaded LDH. In this way, the influence of both inorganic components on the mechanical properties, the water uptake ability, and the kinetics of the drug release from these magnetic systems were determined. In addition, the possibility of modulating the levels of IBU release by stimulating the bionanocomposites with an external magnetic field was also evaluated in in vitro assays.