Phase I study of pemetrexed and cisplatin with concurrent high-dose thoracic radiation after induction chemotherapy in patients with unresectable locally advanced non-small cell lung cancer

Abstract Purpose This is a phase I, escalating-dose trial targeting exclusively patients with non-small cell lung cancer (NSCLC), investigating pemetrexed and fixed-dose cisplatin concurrently administered with high-dose radiotherapy (RT) after induction chemotherapy (CT). Primary objective was to d...

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Bibliographic Details
Published in:	Lung cancer (Amsterdam, Netherlands) Vol. 80; no. 1; pp. 68 - 74
Main Authors:	Mornex, Françoise, Peignaux, Karine, Germain, Thierry, Wautot, Virginie, Chouaki, Nadia, Bourayou, Nawel, Tourani, Jean-Marc
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier Ireland Ltd 01-04-2013 Elsevier
Subjects:	Aged Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - therapy Chemoradiotherapy - adverse effects Chemoradiotherapy - methods Cisplatin Cisplatin - administration & dosage Cisplatin - adverse effects Dose-Response Relationship, Drug Drug Administration Schedule Female Glutamates - administration & dosage Glutamates - adverse effects Guanine - administration & dosage Guanine - adverse effects Guanine - analogs & derivatives Hematology, Oncology and Palliative Medicine Humans Induction Induction Chemotherapy Lung Neoplasms - pathology Lung Neoplasms - therapy Lymphopenia - etiology Male Medical sciences Middle Aged Neoplasm Staging Neutropenia - etiology NSCLC Pemetrexed Phase I trial Pneumology Pulmonary/Respiratory Radiotherapy Radiotherapy Dosage Treatment Outcome Tumors Tumors of the respiratory system and mediastinum Vomiting - etiology Phase I trial NSCLC Radiotherapy Induction Pemetrexed Cisplatin Antineoplastic agent Human Lung disease Respiratory disease Concurrent Malignant tumor non-small cell lung carcinoma Induction treatment Cancerology Unresectable Bronchus disease High dose Cancer Non small cell carcinoma Pneumology
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