DNA Methylation Changes in Human Papillomavirus-Driven Head and Neck Cancers

DNA Methylation Changes in Human Papillomavirus-Driven Head and Neck Cancers

Disruption of DNA methylation patterns is one of the hallmarks of cancer. Similar to other cancer types, human papillomavirus (HPV)-driven head and neck cancer (HNC) also reveals alterations in its methylation profile. The intrinsic ability of HPV oncoproteins E6 and E7 to interfere with DNA methylt...

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Published in:Cells (Basel, Switzerland) Vol. 9; no. 6; p. 1359
Main Authors: Ekanayake Weeramange, Chameera, Tang, Kai Dun, Vasani, Sarju, Langton-Lockton, Julian, Kenny, Liz, Punyadeera, Chamindie
Format: Journal Article
Language:English
Published: Switzerland MDPI 31-05-2020
MDPI AG
Subjects:
Alphapapillomavirus - genetics
Alphapapillomavirus - physiology
Carcinogenesis - genetics
Carcinogenesis - pathology
DNA methylation
DNA Methylation - genetics
DNA, Viral - genetics
Genome, Viral
head and neck cancer
Head and Neck Neoplasms - diagnosis
Head and Neck Neoplasms - genetics
Head and Neck Neoplasms - therapy
Head and Neck Neoplasms - virology
human papillomavirus
Humans
Review
head and neck cancer
DNA methylation
human papillomavirus
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Abstract Disruption of DNA methylation patterns is one of the hallmarks of cancer. Similar to other cancer types, human papillomavirus (HPV)-driven head and neck cancer (HNC) also reveals alterations in its methylation profile. The intrinsic ability of HPV oncoproteins E6 and E7 to interfere with DNA methyltransferase activity contributes to these methylation changes. There are many genes that have been reported to be differentially methylated in HPV-driven HNC. Some of these genes are involved in major cellular pathways, indicating that DNA methylation, at least in certain instances, may contribute to the development and progression of HPV-driven HNC. Furthermore, the HPV genome itself becomes a target of the cellular DNA methylation machinery. Some of these methylation changes appearing in the viral long control region (LCR) may contribute to uncontrolled oncoprotein expression, leading to carcinogenesis. Consistent with these observations, demethylation therapy appears to have significant effects on HPV-driven HNC. This review article comprehensively summarizes DNA methylation changes and their diagnostic and therapeutic indications in HPV-driven HNC.
AbstractList Disruption of DNA methylation patterns is one of the hallmarks of cancer. Similar to other cancer types, human papillomavirus (HPV)-driven head and neck cancer (HNC) also reveals alterations in its methylation profile. The intrinsic ability of HPV oncoproteins E6 and E7 to interfere with DNA methyltransferase activity contributes to these methylation changes. There are many genes that have been reported to be differentially methylated in HPV-driven HNC. Some of these genes are involved in major cellular pathways, indicating that DNA methylation, at least in certain instances, may contribute to the development and progression of HPV-driven HNC. Furthermore, the HPV genome itself becomes a target of the cellular DNA methylation machinery. Some of these methylation changes appearing in the viral long control region (LCR) may contribute to uncontrolled oncoprotein expression, leading to carcinogenesis. Consistent with these observations, demethylation therapy appears to have significant effects on HPV-driven HNC. This review article comprehensively summarizes DNA methylation changes and their diagnostic and therapeutic indications in HPV-driven HNC.
Author Kenny, Liz
Punyadeera, Chamindie
Langton-Lockton, Julian
Vasani, Sarju
Ekanayake Weeramange, Chameera
Tang, Kai Dun
AuthorAffiliation 1 Saliva & Liquid Biopsy Translational Research Team, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology (QUT), Queensland 4059, Australia; s.weeramange@qut.edu.au (C.E.W.); kai.tang@qut.edu.au (K.D.T.)
3 Department of Medical Laboratory Sciences, Faculty of Health Sciences, The Open University of Sri Lanka, Nugegoda 10250, Sri Lanka
4 Department of Otolaryngology, Royal Brisbane and Women’s Hospital, Queensland 4029, Australia; Sarju.Vasani@health.qld.gov.au
5 School of Medicine, The University of Queensland, Queensland 4006, Australia; lizkenny@bigpond.net.au
8 Central Integrated Regional Cancer Service, Queensland Health, Queensland 4001, Australia
2 Translational Research Institute, Queensland University of Technology (QUT), Queensland 4102, Australia
7 Department of Cancer Care Services, Royal Brisbane and Women’s Hospital, Queensland 4029, Australia
6 Metro-North Sexual Health and HIV Service, Queensland 4000, Australia; Jul
AuthorAffiliation_xml – name: 5 School of Medicine, The University of Queensland, Queensland 4006, Australia; lizkenny@bigpond.net.au
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– name: 3 Department of Medical Laboratory Sciences, Faculty of Health Sciences, The Open University of Sri Lanka, Nugegoda 10250, Sri Lanka
– name: 7 Department of Cancer Care Services, Royal Brisbane and Women’s Hospital, Queensland 4029, Australia
– name: 4 Department of Otolaryngology, Royal Brisbane and Women’s Hospital, Queensland 4029, Australia; Sarju.Vasani@health.qld.gov.au
– name: 6 Metro-North Sexual Health and HIV Service, Queensland 4000, Australia; Julian.LangtonLockton@health.qld.gov.au
– name: 1 Saliva & Liquid Biopsy Translational Research Team, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology (QUT), Queensland 4059, Australia; s.weeramange@qut.edu.au (C.E.W.); kai.tang@qut.edu.au (K.D.T.)
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Issue 6
Keywords head and neck cancer
DNA methylation
human papillomavirus
Language English
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Snippet Disruption of DNA methylation patterns is one of the hallmarks of cancer. Similar to other cancer types, human papillomavirus (HPV)-driven head and neck cancer...
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pubmedcentral
crossref
pubmed
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SubjectTerms Alphapapillomavirus - genetics
Alphapapillomavirus - physiology
Carcinogenesis - genetics
Carcinogenesis - pathology
DNA methylation
DNA Methylation - genetics
DNA, Viral - genetics
Genome, Viral
head and neck cancer
Head and Neck Neoplasms - diagnosis
Head and Neck Neoplasms - genetics
Head and Neck Neoplasms - therapy
Head and Neck Neoplasms - virology
human papillomavirus
Humans
Review
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Title DNA Methylation Changes in Human Papillomavirus-Driven Head and Neck Cancers
URI https://www.ncbi.nlm.nih.gov/pubmed/32486347
https://pubmed.ncbi.nlm.nih.gov/PMC7348958
https://doaj.org/article/23389ee3c153479e9d01c48467e097f3
Volume 9
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