Serous ovarian cancer signaling pathways

Ovarian cancer is the most lethal malignancy of the female genital tract, mainly due to the failure of early diagnosis and the limitations posed by the conventional chemotherapies. Current research has focused in the study of cascades of various cellular molecular reactions, known as signaling pathw...

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Bibliographic Details
Published in:	International journal of gynecological cancer Vol. 24; no. 3; p. 410
Main Authors:	Kotsopoulos, Ioannis C, Papanikolaou, Alexios, Lambropoulos, Alexandros F, Papazisis, Konstantinos T, Tsolakidis, Dimitrios, Touplikioti, Panagiota, Tarlatzis, Basil C
Format:	Journal Article
Language:	English
Published:	England 01-03-2014
Subjects:	Cystadenocarcinoma, Serous - etiology Cystadenocarcinoma, Serous - metabolism Female Humans Ovarian Neoplasms - etiology Ovarian Neoplasms - metabolism Signal Transduction
Online Access:	Get more information
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Summary:	Ovarian cancer is the most lethal malignancy of the female genital tract, mainly due to the failure of early diagnosis and the limitations posed by the conventional chemotherapies. Current research has focused in the study of cascades of various cellular molecular reactions, known as signaling pathways. In this review article, authors try to describe the current knowledge regarding the signaling pathways that influence multiple cellular processes in serous ovarian cancer and especially the pathogenesis. Thorough understanding of the precise role of these pathways can lead to the development of new and more effective targeted therapies as well as novel biomarkers in ovarian cancer.
ISSN:	1525-1438
DOI:	10.1097/igc.0000000000000079