Structure of the type VI secretion phospholipase effector Tle1 provides insight into its hydrolysis and membrane targeting

A diverse superfamily of phospholipases consisting of the type VI lipase effectors Tle1–Tle5 secreted by the bacterial type VI secretion system (T6SS) have recently been identified as antibacterial effectors that hydrolyze membrane phospholipids. These effectors show no significant homology to known...

Full description

Saved in:

Bibliographic Details
Published in:	Acta crystallographica. Section D, Biological crystallography. Vol. 70; no. 8; pp. 2175 - 2185
Main Authors:	Hu, Haidai, Zhang, Heng, Gao, Zengqiang, Wang, Dongqi, Liu, Guangfeng, Xu, Jianhua, Lan, Ke, Dong, Yuhui
Format:	Journal Article
Language:	English
Published:	5 Abbey Square, Chester, Cheshire CH1 2HU, England International Union of Crystallography 01-08-2014 Wiley Subscription Services, Inc
Subjects:	Bacteria Catalysis Catalysts Catalytic Domain Effectors Hydrolysis Lipase Membranes Modules Molecular Dynamics Simulation Phospholipase Phospholipases A2 - chemistry Phospholipases A2 - metabolism Protein Conformation Protein Folding Pseudomonas aeruginosa Pseudomonas aeruginosa - enzymology Recombinant Proteins - chemistry Recombinant Proteins - metabolism Tle1 type VI lipase effectors type VI secretion system Pseudomonas aeruginosa type VI lipase effectors Tle1 type VI secretion system
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!