Pharmacometabolomics by NMR in Oncology: A Systematic Review

Pharmacometabolomics by NMR in Oncology: A Systematic Review

Pharmacometabolomics (PMx) studies aim to predict individual differences in treatment response and in the development of adverse effects associated with specific drug treatments. Overall, these studies inform us about how individuals will respond to a drug treatment based on their metabolic profiles...

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Published in:Pharmaceuticals (Basel, Switzerland) Vol. 14; no. 10; p. 1015
Main Authors: Gómez-Cebrián, Nuria, Vázquez Ferreiro, Pedro, Carrera Hueso, Francisco Javier, Poveda Andrés, José Luis, Puchades-Carrasco, Leonor, Pineda-Lucena, Antonio
Format: Journal Article
Language:English
Published: Basel MDPI AG 02-10-2021
MDPI
Subjects:
Clinical trials
drug response
Feces
Metabolism
Metabolites
NMR
Nuclear magnetic resonance
personalized medicine
pharmacometabolomics
Systematic Review
Urine
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Abstract Pharmacometabolomics (PMx) studies aim to predict individual differences in treatment response and in the development of adverse effects associated with specific drug treatments. Overall, these studies inform us about how individuals will respond to a drug treatment based on their metabolic profiles obtained before, during, or after the therapeutic intervention. In the era of precision medicine, metabolic profiles hold great potential to guide patient selection and stratification in clinical trials, with a focus on improving drug efficacy and safety. Metabolomics is closely related to the phenotype as alterations in metabolism reflect changes in the preceding cascade of genomics, transcriptomics, and proteomics changes, thus providing a significant advance over other omics approaches. Nuclear Magnetic Resonance (NMR) is one of the most widely used analytical platforms in metabolomics studies. In fact, since the introduction of PMx studies in 2006, the number of NMR-based PMx studies has been continuously growing and has provided novel insights into the specific metabolic changes associated with different mechanisms of action and/or toxic effects. This review presents an up-to-date summary of NMR-based PMx studies performed over the last 10 years. Our main objective is to discuss the experimental approaches used for the characterization of the metabolic changes associated with specific therapeutic interventions, the most relevant results obtained so far, and some of the remaining challenges in this area.
AbstractList Pharmacometabolomics (PMx) studies aim to predict individual differences in treatment response and in the development of adverse effects associated with specific drug treatments. Overall, these studies inform us about how individuals will respond to a drug treatment based on their metabolic profiles obtained before, during, or after the therapeutic intervention. In the era of precision medicine, metabolic profiles hold great potential to guide patient selection and stratification in clinical trials, with a focus on improving drug efficacy and safety. Metabolomics is closely related to the phenotype as alterations in metabolism reflect changes in the preceding cascade of genomics, transcriptomics, and proteomics changes, thus providing a significant advance over other omics approaches. Nuclear Magnetic Resonance (NMR) is one of the most widely used analytical platforms in metabolomics studies. In fact, since the introduction of PMx studies in 2006, the number of NMR-based PMx studies has been continuously growing and has provided novel insights into the specific metabolic changes associated with different mechanisms of action and/or toxic effects. This review presents an up-to-date summary of NMR-based PMx studies performed over the last 10 years. Our main objective is to discuss the experimental approaches used for the characterization of the metabolic changes associated with specific therapeutic interventions, the most relevant results obtained so far, and some of the remaining challenges in this area.
Author Puchades-Carrasco, Leonor
Vázquez Ferreiro, Pedro
Pineda-Lucena, Antonio
Gómez-Cebrián, Nuria
Poveda Andrés, José Luis
Carrera Hueso, Francisco Javier
AuthorAffiliation 1 Drug Discovery Unit, Instituto de Investigación Sanitaria La Fe, 46026 Valencia, Spain; nuria_gomez@iislafe.es
5 Molecular Therapeutics Program, Centro de Investigación Médica Aplicada, 31008 Navarra, Spain
2 Ophthalmology Department, Hospital Virxen da Xunqueria, 15270 A Coruña, Spain; pedro.vazquez.ferreiro@sergas.es
4 Pharmacy Department, Hospital Universitario y Politécnico La Fe, 46026 Valencia, Spain; poveda_joseand@gva.es
3 Pharmacy Department, Hospital Universitario La Plana, 12004 Castellón, Spain; carrera_fra@gva.es
AuthorAffiliation_xml – name: 2 Ophthalmology Department, Hospital Virxen da Xunqueria, 15270 A Coruña, Spain; pedro.vazquez.ferreiro@sergas.es
– name: 5 Molecular Therapeutics Program, Centro de Investigación Médica Aplicada, 31008 Navarra, Spain
– name: 4 Pharmacy Department, Hospital Universitario y Politécnico La Fe, 46026 Valencia, Spain; poveda_joseand@gva.es
– name: 1 Drug Discovery Unit, Instituto de Investigación Sanitaria La Fe, 46026 Valencia, Spain; nuria_gomez@iislafe.es
– name: 3 Pharmacy Department, Hospital Universitario La Plana, 12004 Castellón, Spain; carrera_fra@gva.es
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CitedBy_id crossref_primary_10_3390_ijms24043291
crossref_primary_10_1089_omi_2022_0097
crossref_primary_10_3389_fcimb_2022_882661
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drug response
Feces
Metabolism
Metabolites
NMR
Nuclear magnetic resonance
personalized medicine
pharmacometabolomics
Systematic Review
Urine
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Title Pharmacometabolomics by NMR in Oncology: A Systematic Review
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