ORP5 and ORP8 orchestrate lipid droplet biogenesis and maintenance at ER-mitochondria contact sites

Lipid droplets (LDs) are the primary organelles of lipid storage, buffering energy fluctuations of the cell. They store neutral lipids in their core that is surrounded by a protein-decorated phospholipid monolayer. LDs arise from the endoplasmic reticulum (ER). The ER protein seipin, localizing at E...

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Bibliographic Details
Published in:	The Journal of cell biology Vol. 221; no. 9; p. 1
Main Authors:	Guyard, Valentin, Monteiro-Cardoso, Vera Filipa, Omrane, Mohyeddine, Sauvanet, Cécile, Houcine, Audrey, Boulogne, Claire, Ben Mbarek, Kalthoum, Vitale, Nicolas, Faklaris, Orestis, El Khallouki, Naima, Thiam, Abdou Rachid, Giordano, Francesca
Format:	Journal Article
Language:	English
Published:	United States Rockefeller University Press 05-09-2022
Subjects:	Biochemistry Biosynthesis Crosstalk Droplets Endoplasmic reticulum Endoplasmic Reticulum - metabolism Energy storage Life Sciences Lipid Droplets - metabolism Lipid Metabolism Lipid transfer proteins Lipids Membranes Mitochondria Mitochondria - metabolism Nucleation Organelles Phosphatidic acid Phospholipids Phospholipids - metabolism Proteins Receptors, Steroid - metabolism Biochemistry, Organelles
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