The Role of Zinc in the Development of Vascular Dementia and Parkinson's Disease and the Potential of Carnosine as Their Therapeutic Agent

The Role of Zinc in the Development of Vascular Dementia and Parkinson's Disease and the Potential of Carnosine as Their Therapeutic Agent

Synaptic zinc ions (Zn ) play an important role in the development of vascular dementia (VD) and Parkinson's disease (PD). In this article, we reviewed the current comprehension of the Zn -induced neurotoxicity that leads to the pathogenesis of these neuronal diseases. Zn -induced neurotoxicity...

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Published in:Biomedicines Vol. 12; no. 6; p. 1296
Main Authors: Mizuno, Dai, Kawahara, Masahiro, Konoha-Mizuno, Keiko, Hama, Ryoji, Ogawara, Terumasa
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 11-06-2024
MDPI
Subjects:
Amino acids
Anguilla japonica
Apoptosis
Binswanger's disease
Carnosine
Cell death
Cytotoxicity
Dementia
Dementia disorders
Diet therapy
Disease
Diseases
Dopamine
endoplasmic reticulum stress
Enzymes
Ethylenediaminetetraacetic acid
Genes
Health aspects
Homeostasis
Hypothalamus
Ischemia
Japan
Kinases
Molecular modelling
Movement disorders
Neurodegenerative diseases
Neurotoxicity
Older people
Oxidative stress
Parkinson's disease
Pathogenesis
Physiological aspects
Proteins
Review
Sexually transmitted diseases
STD
synapse
Synaptogenesis
Therapeutic applications
Transcription factors
Vascular dementia
Zinc
Japan
carnosine
vascular dementia
apoptosis
synapse
zinc
Parkinson’s disease
endoplasmic reticulum stress
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Abstract Synaptic zinc ions (Zn ) play an important role in the development of vascular dementia (VD) and Parkinson's disease (PD). In this article, we reviewed the current comprehension of the Zn -induced neurotoxicity that leads to the pathogenesis of these neuronal diseases. Zn -induced neurotoxicity was investigated by using immortalised hypothalamic neurons (GT1-7 cells). This cell line is useful for the development of a rapid and convenient screening system for investigating Zn -induced neurotoxicity. GT1-7 cells were also used to search for substances that prevent Zn -induced neurotoxicity. Among the tested substances was a protective substance in the extract of Japanese eel ( ), and we determined its structure to be like carnosine (β-alanylhistidine). Carnosine may be a therapeutic drug for VD and PD. Furthermore, we reviewed the molecular mechanisms that involve the role of carnosine as an endogenous protector and its protective effect against Zn -induced cytotoxicity and discussed the prospects for the future therapeutic applications of this dipeptide for neurodegenerative diseases and dementia.
AbstractList Synaptic zinc ions (Zn ) play an important role in the development of vascular dementia (VD) and Parkinson's disease (PD). In this article, we reviewed the current comprehension of the Zn -induced neurotoxicity that leads to the pathogenesis of these neuronal diseases. Zn -induced neurotoxicity was investigated by using immortalised hypothalamic neurons (GT1-7 cells). This cell line is useful for the development of a rapid and convenient screening system for investigating Zn -induced neurotoxicity. GT1-7 cells were also used to search for substances that prevent Zn -induced neurotoxicity. Among the tested substances was a protective substance in the extract of Japanese eel ( ), and we determined its structure to be like carnosine (β-alanylhistidine). Carnosine may be a therapeutic drug for VD and PD. Furthermore, we reviewed the molecular mechanisms that involve the role of carnosine as an endogenous protector and its protective effect against Zn -induced cytotoxicity and discussed the prospects for the future therapeutic applications of this dipeptide for neurodegenerative diseases and dementia.
Synaptic zinc ions (Zn 2+ ) play an important role in the development of vascular dementia (VD) and Parkinson’s disease (PD). In this article, we reviewed the current comprehension of the Zn 2+ -induced neurotoxicity that leads to the pathogenesis of these neuronal diseases. Zn 2+ -induced neurotoxicity was investigated by using immortalised hypothalamic neurons (GT1-7 cells). This cell line is useful for the development of a rapid and convenient screening system for investigating Zn 2+ -induced neurotoxicity. GT1-7 cells were also used to search for substances that prevent Zn 2+ -induced neurotoxicity. Among the tested substances was a protective substance in the extract of Japanese eel ( Anguilla japonica ), and we determined its structure to be like carnosine (β-alanylhistidine). Carnosine may be a therapeutic drug for VD and PD. Furthermore, we reviewed the molecular mechanisms that involve the role of carnosine as an endogenous protector and its protective effect against Zn 2+ -induced cytotoxicity and discussed the prospects for the future therapeutic applications of this dipeptide for neurodegenerative diseases and dementia.
Synaptic zinc ions (Zn2+) play an important role in the development of vascular dementia (VD) and Parkinson's disease (PD). In this article, we reviewed the current comprehension of the Zn2+-induced neurotoxicity that leads to the pathogenesis of these neuronal diseases. Zn2+-induced neurotoxicity was investigated by using immortalised hypothalamic neurons (GT1-7 cells). This cell line is useful for the development of a rapid and convenient screening system for investigating Zn2+-induced neurotoxicity. GT1-7 cells were also used to search for substances that prevent Zn2+-induced neurotoxicity. Among the tested substances was a protective substance in the extract of Japanese eel (Anguilla japonica), and we determined its structure to be like carnosine (β-alanylhistidine). Carnosine may be a therapeutic drug for VD and PD. Furthermore, we reviewed the molecular mechanisms that involve the role of carnosine as an endogenous protector and its protective effect against Zn2+-induced cytotoxicity and discussed the prospects for the future therapeutic applications of this dipeptide for neurodegenerative diseases and dementia.Synaptic zinc ions (Zn2+) play an important role in the development of vascular dementia (VD) and Parkinson's disease (PD). In this article, we reviewed the current comprehension of the Zn2+-induced neurotoxicity that leads to the pathogenesis of these neuronal diseases. Zn2+-induced neurotoxicity was investigated by using immortalised hypothalamic neurons (GT1-7 cells). This cell line is useful for the development of a rapid and convenient screening system for investigating Zn2+-induced neurotoxicity. GT1-7 cells were also used to search for substances that prevent Zn2+-induced neurotoxicity. Among the tested substances was a protective substance in the extract of Japanese eel (Anguilla japonica), and we determined its structure to be like carnosine (β-alanylhistidine). Carnosine may be a therapeutic drug for VD and PD. Furthermore, we reviewed the molecular mechanisms that involve the role of carnosine as an endogenous protector and its protective effect against Zn2+-induced cytotoxicity and discussed the prospects for the future therapeutic applications of this dipeptide for neurodegenerative diseases and dementia.
Synaptic zinc ions (Zn2+) play an important role in the development of vascular dementia (VD) and Parkinson’s disease (PD). In this article, we reviewed the current comprehension of the Zn2+-induced neurotoxicity that leads to the pathogenesis of these neuronal diseases. Zn2+-induced neurotoxicity was investigated by using immortalised hypothalamic neurons (GT1-7 cells). This cell line is useful for the development of a rapid and convenient screening system for investigating Zn2+-induced neurotoxicity. GT1-7 cells were also used to search for substances that prevent Zn2+-induced neurotoxicity. Among the tested substances was a protective substance in the extract of Japanese eel (Anguilla japonica), and we determined its structure to be like carnosine (β-alanylhistidine). Carnosine may be a therapeutic drug for VD and PD. Furthermore, we reviewed the molecular mechanisms that involve the role of carnosine as an endogenous protector and its protective effect against Zn2+-induced cytotoxicity and discussed the prospects for the future therapeutic applications of this dipeptide for neurodegenerative diseases and dementia.
Synaptic zinc ions (Zn[sup.2+]) play an important role in the development of vascular dementia (VD) and Parkinson’s disease (PD). In this article, we reviewed the current comprehension of the Zn[sup.2+]-induced neurotoxicity that leads to the pathogenesis of these neuronal diseases. Zn[sup.2+]-induced neurotoxicity was investigated by using immortalised hypothalamic neurons (GT1-7 cells). This cell line is useful for the development of a rapid and convenient screening system for investigating Zn[sup.2+]-induced neurotoxicity. GT1-7 cells were also used to search for substances that prevent Zn[sup.2+]-induced neurotoxicity. Among the tested substances was a protective substance in the extract of Japanese eel (Anguilla japonica), and we determined its structure to be like carnosine (β-alanylhistidine). Carnosine may be a therapeutic drug for VD and PD. Furthermore, we reviewed the molecular mechanisms that involve the role of carnosine as an endogenous protector and its protective effect against Zn[sup.2+]-induced cytotoxicity and discussed the prospects for the future therapeutic applications of this dipeptide for neurodegenerative diseases and dementia.
Audience Academic
Author Mizuno, Dai
Hama, Ryoji
Kawahara, Masahiro
Konoha-Mizuno, Keiko
Ogawara, Terumasa
AuthorAffiliation 2 Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, Musashino University, 1-1-20 Shin-machi, Nishitokyo-shi 202-8585, Tokyo, Japan; makawa@musashino-u.ac.jp
1 Department of Forensic Medicine, Faculty of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata-shi 990-9585, Yamagata, Japan; k_mizuno@med.id.yamagata-u.ac.jp (K.K.-M.); hama-ryoji@med.id.yamagata-u.ac.jp (R.H.); t.ogawara@med.id.yamagata-u.ac.jp (T.O.)
AuthorAffiliation_xml – name: 1 Department of Forensic Medicine, Faculty of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata-shi 990-9585, Yamagata, Japan; k_mizuno@med.id.yamagata-u.ac.jp (K.K.-M.); hama-ryoji@med.id.yamagata-u.ac.jp (R.H.); t.ogawara@med.id.yamagata-u.ac.jp (T.O.)
– name: 2 Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, Musashino University, 1-1-20 Shin-machi, Nishitokyo-shi 202-8585, Tokyo, Japan; makawa@musashino-u.ac.jp
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  surname: Mizuno
  fullname: Mizuno, Dai
  organization: Department of Forensic Medicine, Faculty of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata-shi 990-9585, Yamagata, Japan
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  givenname: Masahiro
  orcidid: 0000-0002-3334-4235
  surname: Kawahara
  fullname: Kawahara, Masahiro
  organization: Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, Musashino University, 1-1-20 Shin-machi, Nishitokyo-shi 202-8585, Tokyo, Japan
– sequence: 3
  givenname: Keiko
  surname: Konoha-Mizuno
  fullname: Konoha-Mizuno, Keiko
  organization: Department of Forensic Medicine, Faculty of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata-shi 990-9585, Yamagata, Japan
– sequence: 4
  givenname: Ryoji
  surname: Hama
  fullname: Hama, Ryoji
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– sequence: 5
  givenname: Terumasa
  surname: Ogawara
  fullname: Ogawara, Terumasa
  organization: Department of Forensic Medicine, Faculty of Medicine, Yamagata University, 2-2-2 Iida-Nishi, Yamagata-shi 990-9585, Yamagata, Japan
BackLink https://www.ncbi.nlm.nih.gov/pubmed/38927502$$D View this record in MEDLINE/PubMed
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Keywords carnosine
vascular dementia
apoptosis
synapse
zinc
Parkinson’s disease
endoplasmic reticulum stress
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Snippet Synaptic zinc ions (Zn ) play an important role in the development of vascular dementia (VD) and Parkinson's disease (PD). In this article, we reviewed the...
Synaptic zinc ions (Zn2+) play an important role in the development of vascular dementia (VD) and Parkinson’s disease (PD). In this article, we reviewed the...
Synaptic zinc ions (Zn[sup.2+]) play an important role in the development of vascular dementia (VD) and Parkinson’s disease (PD). In this article, we reviewed...
Synaptic zinc ions (Zn2+) play an important role in the development of vascular dementia (VD) and Parkinson's disease (PD). In this article, we reviewed the...
Synaptic zinc ions (Zn 2+ ) play an important role in the development of vascular dementia (VD) and Parkinson’s disease (PD). In this article, we reviewed the...
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SubjectTerms Amino acids
Anguilla japonica
Apoptosis
Binswanger's disease
Carnosine
Cell death
Cytotoxicity
Dementia
Dementia disorders
Diet therapy
Disease
Diseases
Dopamine
endoplasmic reticulum stress
Enzymes
Ethylenediaminetetraacetic acid
Genes
Health aspects
Homeostasis
Hypothalamus
Ischemia
Japan
Kinases
Molecular modelling
Movement disorders
Neurodegenerative diseases
Neurotoxicity
Older people
Oxidative stress
Parkinson's disease
Pathogenesis
Physiological aspects
Proteins
Review
Sexually transmitted diseases
STD
synapse
Synaptogenesis
Therapeutic applications
Transcription factors
Vascular dementia
Zinc
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Title The Role of Zinc in the Development of Vascular Dementia and Parkinson's Disease and the Potential of Carnosine as Their Therapeutic Agent
URI https://www.ncbi.nlm.nih.gov/pubmed/38927502
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