Direct participation of DNA in the formation of singlet oxygen and base damage under UVA irradiation

UVA light is hardly absorbed by the DNA molecule, but recent works point to a direct mechanism of DNA lesion by these wavelengths. UVA light also excite endogenous chromophores, which causes DNA damage through ROS. In this study, DNA samples were irradiated with UVA light in different conditions to...

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Bibliographic Details
Published in:	Free radical biology & medicine Vol. 108; pp. 86 - 93
Main Authors:	Yagura, Teiti, Schuch, André Passaglia, Garcia, Camila Carrião Machado, Rocha, Clarissa Ribeiro Reily, Moreno, Natália Cestari, Angeli, José Pedro Friedmann, Mendes, Davi, Severino, Divinomar, Bianchini Sanchez, Angelica, Di Mascio, Paolo, de Medeiros, Marisa Helena Gennari, Menck, Carlos Frederico Martins
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-07-2017
Subjects:	Animals Antibodies, Antinuclear - metabolism Cattle Cell-Free System Deoxyguanosine - analogs & derivatives Deoxyguanosine - chemistry Deoxyguanosine - metabolism DNA - chemistry DNA - immunology DNA - radiation effects DNA Damage Oxidative Stress Photosensitivity Disorders Pyrimidine Dimers - chemistry Singlet oxygen Singlet Oxygen - chemistry Sodium Chloride - metabolism Sunlight Thymus Gland - physiology Ultraviolet radiation Ultraviolet Rays - adverse effects Ultraviolet radiation DNA damage Singlet oxygen
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