Does the Combined Effect of Resistance Training with EPO and Iron Sulfate Improve Iron Metabolism in Older Individuals with End-Stage Renal Disease?

• Published in: Nutrients Vol. 13; no. 9; p. 3250
• Main Authors: Corrêa, Hugo de Luca, Alfaro-Magallanes, Víctor Manuel, Moura, Sting Ray Gouveia, Neves, Rodrigo Vanerson Passos, Deus, Lysleine Alves, Honorato, Fernando Sousa, Silva, Victor Lopes, Raab, Artur Temizio Oppelt, Maia, Beatriz Carneiro Habbema, Padula, Isabela Akaishi, Gusmão Alves, Lucas Santos de, Machado, Rafaela Araújo, Reis, Andrea Lucena, Prestes, Jonato, Ferreira, Carlos Ernesto Santos, Neto, Luiz Sinésio da Silva, Tavares, Fernanda Silveira, Andrade, Rosângela Vieira, Rosa, Thiago dos Santos
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 18-09-2021; MDPI
• Subjects: Anemia; Body mass; Body mass index; Body size; chronic kidney disease; Cytotoxicity; End-stage renal disease; Erythropoietin; exercise training; Ferritin; Hemodialysis; Hemoglobin; Hepcidin; Inflammation; Iron; iron metabolism; Iron sulfates; Kidney diseases; Lymphocytes T; Metabolism; Nutrient deficiency; Physical training; Resistance training; Strength training; Sulfate resistance; Sulfates; United States > US
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu13093250

We sought to investigate the effects of resistance training (RT) combined with erythropoietin (EPO) and iron sulfate on the hemoglobin, hepcidin, ferritin, iron status, and inflammatory profile in older individuals with end-stage renal disease (ESRD). ESRD patients (n: 157; age: 66.8 ± 3.6; body mass: 73 ± 15; body mass index: 27 ± 3), were assigned to control (CTL; n: 76) and exercise groups (RT; n: 81). The CTL group was divided according to the iron treatment received: without iron treatment (CTL—none; n = 19), treated only with iron sulfate or EPO (CTL—EPO or IRON; n = 19), and treated with both iron sulfate and EPO (CTL—EPO + IRON; n = 76). The RT group followed the same pattern: (RT—none; n = 20), (RT—EPO or IRON; n = 18), and (RT—EPO + IRON; n = 86). RT consisted of 24 weeks/3 days per week at moderate intensity of full-body resistance exercises prior to the hemodialysis section. The RT group, regardless of the iron treatment, improved iron metabolism in older individuals with ESRD. These results provide some clues on the effects of RT and its combination with EPO and iron sulfate in this population, highlighting RT as an important coadjutant in ESRD-iron deficiency.