Chronic administration of fluoxetine impairs neurogenic and endothelium-dependent relaxation of the rabbit corpus cavernosum smooth muscle

Antidepressants, including selective serotonin reuptake inhibitors (SSRIs), cause erectile dysfunction; however, the mechanism by which they cause erectile function is unclear. We investigated the reactivity of the corpus cavernosum after chronic fluoxetine treatment in rabbits. Twelve rabbits were...

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Bibliographic Details
Published in:	European journal of pharmacology Vol. 670; no. 1; pp. 224 - 228
Main Authors:	Göçmez, Semil Selcen, Utkan, Tijen, Gacar, Nejat, Sarioglu, Yusuf
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 16-11-2011 Elsevier
Subjects:	acetylcholine agonists Animals antidepressants Biological and medical sciences Corpus cavernosum Cyclic GMP - metabolism Dose-Response Relationship, Drug electric field Electric Stimulation Endothelium - cytology Endothelium - drug effects Endothelium - metabolism Endothelium - physiology Erectile dysfunction Fluoxetine Fluoxetine - administration & dosage Fluoxetine - pharmacology In Vitro Techniques Male Medical sciences Muscle Relaxation - drug effects Muscle, Smooth - cytology Muscle, Smooth - drug effects Muscle, Smooth - metabolism Muscle, Smooth - physiology Nervous System Physiological Phenomena - drug effects Nitric oxide Nitric Oxide - metabolism nitroprusside Penile Erection - drug effects Penile Erection - physiology Penis Penis - cytology Penis - drug effects Penis - metabolism Penis - physiology Pharmacology. Drug treatments phenylephrine Rabbit Rabbits serotonin Serotonin Uptake Inhibitors - administration & dosage Serotonin Uptake Inhibitors - pharmacology smooth muscle Time Factors Rabbit Corpus cavernosum Erectile dysfunction Penis Fluoxetine Nitric oxide Serotonin Erection disorders Psychotropic Smooth muscle Reuptake inhibitor Lagomorpha Male genital system Selective serotonin reuptake inhibitor Endothelium Vertebrata Chronic Mammalia Animal Neurotransmitter Antidepressant agent Male genital diseases
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