Disturbed Flow-Induced Endothelial Proatherogenic Signaling Via Regulating Post-Translational Modifications and Epigenetic Events

Hemodynamic shear stress, the frictional force exerted onto the vascular endothelial cell (EC) surface, influences vascular EC functions. Atherosclerotic plaque formation in the endothelium is known to be site specific: disturbed blood flow (d-flow) formed at the lesser curvature of the aortic arch...

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Bibliographic Details
Published in:	Antioxidants & redox signaling Vol. 25; no. 7; p. 435
Main Authors:	Heo, Kyung-Sun, Berk, Bradford C, Abe, Jun-Ichi
Format:	Journal Article
Language:	English
Published:	United States 01-09-2016
Subjects:	Animals Atherosclerosis - etiology Atherosclerosis - metabolism Atherosclerosis - pathology Biomarkers DNA Methylation Endothelial Cells - metabolism Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Epigenesis, Genetic Gene Expression Regulation Humans Inflammasomes - metabolism Mechanotransduction, Cellular Promoter Regions, Genetic Protein Processing, Post-Translational Regional Blood Flow Signal Transduction Sumoylation
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