Phenomenologically distinct psychotomimetic effects of ketamine are associated with cerebral blood flow changes in functionally relevant cerebral foci: a continuous arterial spin labelling study

Rationale The N-methyl-D-aspartate (NMDA) receptor antagonist ketamine provides a pragmatic approach to address the link between glutamate-mediated changes in brain function and psychosis-like experiences. Most studies using PET or BOLD fMRI have assessed these symptoms broadly, which may limit infe...

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Bibliographic Details
Published in:	Psychopharmacology Vol. 232; no. 24; pp. 4515 - 4524
Main Authors:	Pollak, T. A., De Simoni, S., Barimani, B., Zelaya, F. O., Stone, J. M., Mehta, M. A.
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01-12-2015 Springer Nature B.V
Subjects:	Adult Antagonist drugs Biomedical and Life Sciences Biomedicine Brain Cerebrovascular Circulation - drug effects Excitatory Amino Acid Antagonists - pharmacology Gyrus Cinguli - drug effects Humans Ketamine - pharmacology Male Medical imaging Neuropsychological Tests Neurosciences Original Investigation Perception - drug effects Pharmacology/Toxicology Phenomenology Psychiatry Psychopharmacology Spin Labels Thinking - drug effects Young Adult Neuroimaging Glutamate receptor Cerebral blood flow NMDA Receptor
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