A novel histological lesion in glucocorticoid-responsive chronic hepatitis

In patients with chronic hepatitis, the diagnosis of autoimmune hepatitis is made on the basis of increased gamma-globulin levels and the presence of circulating autoantibodies. Because these test results are not abnormal universally in patients with autoimmune hepatitis, liver biopsy remains an imp...

Full description

Saved in:

Bibliographic Details
Published in:	Gastroenterology (New York, N.Y. 1943) Vol. 113; no. 2; pp. 664 - 668
Main Authors:	Pratt, DS, Fawaz, KA, Rabson, A, Dellelis, R, Kaplan, MM
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01-08-1997 Elsevier
Subjects:	Adult Autoantibodies - analysis Autoimmune Diseases - diagnosis Autoimmune Diseases - drug therapy Autoimmune Diseases - pathology Biological and medical sciences Biopsy - methods Female gamma-Globulins - analysis Gastroenterology. Liver. Pancreas. Abdomen Glucocorticoids - therapeutic use Hepatitis, Chronic - diagnosis Hepatitis, Chronic - drug therapy Hepatitis, Chronic - pathology Humans Liver - pathology Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Other diseases. Semiology Autoimmunity Human Immunopathology Evaluation Steroid hormone Instrumentation therapy Hepatic disease Glucocorticoid Percutaneous route Case study Hepatitis Chronic Histopathology Biopsy Adrenal hormone Digestive diseases
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	In patients with chronic hepatitis, the diagnosis of autoimmune hepatitis is made on the basis of increased gamma-globulin levels and the presence of circulating autoantibodies. Because these test results are not abnormal universally in patients with autoimmune hepatitis, liver biopsy remains an important part of the evaluation. The classical histological finding in autoimmune hepatitis is lymphocytic infiltration of the portal triads and periportal zone (zone 1) with periportal hepatocyte necrosis. This case report describes 4 patients with glucocorticoid-responsive hepatitis, presumably autoimmune in nature, who had pericentral necrosis (zone 3) with relative sparing of the portal areas in their liver biopsy specimens, a previously undescribed histological finding in autoimmune hepatitis. (Gastroenterology 1997 Aug;113(2):664-8)
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0016-5085 1528-0012
DOI:	10.1053/gast.1997.v113.pm9247489