Antimicrobial activity of human eosinophil granule proteins: involvement in host defence against pathogens

Eosinophils have been associated with the pathophysiology of various allergic diseases and asthma. Eosinophils secrete a number of granule proteins that have been identified as effector molecules responsible for many of the actions of eosinophils. The four major eosinophil granule proteins, major ba...

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Bibliographic Details
Published in:	Critical reviews in microbiology Vol. 38; no. 2; p. 168
Main Authors:	Malik, Anu, Batra, Janendra K
Format:	Journal Article
Language:	English
Published:	England 01-05-2012
Subjects:	Anti-Infective Agents - immunology Anti-Infective Agents - pharmacology Communicable Diseases - immunology Communicable Diseases - microbiology Communicable Diseases - parasitology Communicable Diseases - virology Eosinophil Granule Proteins - immunology Eosinophil Granule Proteins - pharmacology Eosinophils - immunology Humans
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Summary:	Eosinophils have been associated with the pathophysiology of various allergic diseases and asthma. Eosinophils secrete a number of granule proteins that have been identified as effector molecules responsible for many of the actions of eosinophils. The four major eosinophil granule proteins, major basic protein (MBP), eosinophil cationic protein (ECP), eosinophil derived neurotoxin (EDN) and eosinophil peroxidase have been shown to be involved in a number of eosinophil associated functions. EDN possesses antiviral activity against single stranded RNA viruses like respiratory syncytial virus, Hepatitis and HIV, whereas ECP and MBP have antibacterial and antiparasitic properties. This review summarizes the studies on antipathogenic activities of eosinophil granule proteins against bacteria, viruses, protozoans and helminths.
ISSN:	1549-7828
DOI:	10.3109/1040841X.2011.645519