Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation

The signaling mechanisms leading to the formation of neutrophil extracellular traps (NETs), relevant in infections, sepsis and autoimmune diseases, are poorly understood. Neutrophils are not amenable to studies with conventional genetic techniques. Using a new chemical genetic analysis we show that...

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Bibliographic Details
Published in:	Nature chemical biology Vol. 7; no. 2; pp. 75 - 77
Main Authors:	Zychlinsky, Arturo, Waldmann, Herbert, Hakkim, Abdul, Fuchs, Tobias A, Martinez, Nancy E, Hess, Simone, Prinz, Heino
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01-02-2011 Nature Publishing Group
Subjects:	631/250/2504/223/1699 631/80/79/750 631/80/86 631/92/93 Autoimmune diseases Biochemical Engineering Biochemistry Bioorganic Chemistry brief-communication Cell Biology Cellular biology Chemistry Chemistry and Materials Science Chemistry/Food Science Extracellular Signal-Regulated MAP Kinases - metabolism Genetics Humans MAP Kinase Kinase Kinases - metabolism Neutrophils - metabolism Proteins Signal transduction
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Summary:	The signaling mechanisms leading to the formation of neutrophil extracellular traps (NETs), relevant in infections, sepsis and autoimmune diseases, are poorly understood. Neutrophils are not amenable to studies with conventional genetic techniques. Using a new chemical genetic analysis we show that the Raf-MEK-ERK pathway is involved in NET formation through activation of NADPH oxidase and upregulation of antiapoptotic proteins. We identify potential targets for drugs addressing NET-associated diseases.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1552-4450 1552-4469
DOI:	10.1038/nchembio.496