Combining Radioimmunotherapy with Antihypoxia Therapy 2-Deoxy-d-Glucose Results in Reduction of Therapeutic Efficacy

Purpose: The efficacy of solid tumor radioimmunotherapy is reduced by heterogeneous tumor distribution of the radionuclide, with dose mainly deposited in the normoxic region and by the relative radioresistance of hypoxic tumor cells. In an attempt to overcome these challenges, radioimmunotherapy was...

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Bibliographic Details
Published in:	Clinical cancer research Vol. 13; no. 6; pp. 1903 - 1910
Main Authors:	DEARLING, Jason L. J, QURESHI, Uzma, BEGENT, Richard H. J, PEDLEY, R. Barbara
Format:	Journal Article
Language:	English
Published:	Philadelphia, PA American Association for Cancer Research 15-03-2007
Subjects:	2DG Adenocarcinoma - drug therapy Adenocarcinoma - mortality Adenocarcinoma - pathology Adenocarcinoma - radiotherapy Animals Antineoplastic agents Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use ATP-depleting therapy Biological and medical sciences Cell Hypoxia Colonic Neoplasms - drug therapy Colonic Neoplasms - mortality Colonic Neoplasms - pathology Colonic Neoplasms - radiotherapy combination therapies Combined Modality Therapy - adverse effects Deoxyglucose - adverse effects Deoxyglucose - therapeutic use Female Humans Medical sciences Mice Mice, Nude Pharmacology. Drug treatments radioimmunotherapy Radioimmunotherapy - adverse effects Radioimmunotherapy - methods Survival Analysis Tumor Burden - drug effects Tumor Burden - radiation effects Xenograft Model Antitumor Assays Immunoradiotherapy Treatment Glucose Radiotherapy Treatment efficiency
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