The role of stroma in immune recognition and destruction of well-established solid tumors
Well-established solid tumors (at least 14 days old and >1 cm in average diameter) are extremely difficult to eradicate immunologically in mice. Most cancer patients that seek medical attention bear primary or metastatic tumors that have grown for longer and that are larger than the tumors we cal...
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| Published in: | Current Opinion in Immunology Vol. 18; no. 2; pp. 226 - 231 |
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| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
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England
Elsevier Ltd
01-04-2006
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| Abstract | Well-established solid tumors (at least 14 days old and >1
cm in average diameter) are extremely difficult to eradicate immunologically in mice. Most cancer patients that seek medical attention bear primary or metastatic tumors that have grown for longer and that are larger than the tumors we call established. Therefore, focusing research on the problems of rejecting well-established mouse tumors might help in the development of novel concepts and protocols for destroying tumors in patients. A particular problem with established cancers is that even when treatments induce temporary regression, cancer often recurs. Recent studies suggest that manipulation of the stromal microenvironment of these tumors can induce immune recognition and regression. Furthermore, targeting cancer cells as well as tumor stroma for immune destruction might be needed to prevent recurrence. |
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| AbstractList | Well-established solid tumors (at least 14 days old and >1 cm in average diameter) are extremely difficult to eradicate immunologically in mice. Most cancer patients that seek medical attention bear primary or metastatic tumors that have grown for longer and that are larger than the tumors we call established. Therefore, focusing research on the problems of rejecting well- established mouse tumors might help in the development of novel concepts and protocols for destroying tumors in patients. A particular problem with established cancers is that even when treatments induce temporary regression, cancer often recurs. Recent studies suggest that manipulation of the stromal microenvironment of these tumors can induce immune recognition and regression. Furthermore, targeting cancer cells as well as tumor stroma for immune destruction might be needed to prevent recurrence. Well-established solid tumors (at least 14 days old and >1cm in average diameter) are extremely difficult to eradicate immunologically in mice. Most cancer patients that seek medical attention bear primary or metastatic tumors that have grown for longer and that are larger than the tumors we call established. Therefore, focusing research on the problems of rejecting well-established mouse tumors might help in the development of novel concepts and protocols for destroying tumors in patients. A particular problem with established cancers is that even when treatments induce temporary regression, cancer often recurs. Recent studies suggest that manipulation of the stromal microenvironment of these tumors can induce immune recognition and regression. Furthermore, targeting cancer cells as well as tumor stroma for immune destruction might be needed to prevent recurrence. Well-established solid tumors (at least 14 days old and >1 cm in average diameter) are extremely difficult to eradicate immunologically in mice. Most cancer patients that seek medical attention bear primary or metastatic tumors that have grown for longer and that are larger than the tumors we call established. Therefore, focusing research on the problems of rejecting well-established mouse tumors might help in the development of novel concepts and protocols for destroying tumors in patients. A particular problem with established cancers is that even when treatments induce temporary regression, cancer often recurs. Recent studies suggest that manipulation of the stromal microenvironment of these tumors can induce immune recognition and regression. Furthermore, targeting cancer cells as well as tumor stroma for immune destruction might be needed to prevent recurrence. Well-established solid tumors (at least 14 days old and >1cm in average diameter) are extremely difficult to eradicate immunologically in mice. Most cancer patients that seek medical attention bear primary or metastatic tumors that have grown for longer and that are larger than the tumors we call established. Therefore, focusing research on the problems of rejecting well-established mouse tumors might help in the development of novel concepts and protocols for destroying tumors in patients. A particular problem with established cancers is that even when treatments induce temporary regression, cancer often recurs. Recent studies suggest that manipulation of the stromal microenvironment of these tumors can induce immune recognition and regression. Furthermore, targeting cancer cells as well as tumor stroma for immune destruction might be needed to prevent recurrence. |
| Author | Rowley, Donald A Schreiber, Hans Fu, Yang-Xin Yu, Ping |
| Author_xml | – sequence: 1 givenname: Ping surname: Yu fullname: Yu, Ping – sequence: 2 givenname: Donald A surname: Rowley fullname: Rowley, Donald A – sequence: 3 givenname: Yang-Xin surname: Fu fullname: Fu, Yang-Xin – sequence: 4 givenname: Hans surname: Schreiber fullname: Schreiber, Hans email: hszz@midway.uchicago.edu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/16459066$$D View this record in MEDLINE/PubMed |
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| Snippet | Well-established solid tumors (at least 14 days old and >1
cm in average diameter) are extremely difficult to eradicate immunologically in mice. Most cancer... Well-established solid tumors (at least 14 days old and >1cm in average diameter) are extremely difficult to eradicate immunologically in mice. Most cancer... Well-established solid tumors (at least 14 days old and >1 cm in average diameter) are extremely difficult to eradicate immunologically in mice. Most cancer... Well-established solid tumors (at least 14 days old and >1cm in average diameter) are extremely difficult to eradicate immunologically in mice. Most cancer... |
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| Title | The role of stroma in immune recognition and destruction of well-established solid tumors |
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