Irinophore C: A Liposome Formulation of Irinotecan with Substantially Improved Therapeutic Efficacy against a Panel of Human Xenograft Tumors

Purpose: To assess the pharmacokinetics, tumor drug accumulation, and therapeutic activity of Irinophore C, a novel liposomal formulation of irinotecan (CPT-11). Experimental Design: The plasma lactone/carboxy levels of CPT-11 and SN-38 were determined in mice after a single i.v. dose of irinotecan...

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Bibliographic Details
Published in:	Clinical cancer research Vol. 14; no. 4; pp. 1208 - 1217
Main Authors:	RAMSAY, Euan C, ANANTHA, Malathi, ZASTRE, Jason, MEIJS, Marieke, ZONDERHUIS, Jet, STRUTT, Dita, WEBB, Murray S, WATERHOUSE, Dawn, BALLYL, Marcel B
Format:	Journal Article
Language:	English
Published:	Philadelphia, PA American Association for Cancer Research 15-02-2008
Subjects:	Animals Antineoplastic agents Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacokinetics Biological and medical sciences Camptothecin - administration & dosage Camptothecin - analogs & derivatives Camptothecin - pharmacokinetics cancer xenografts CPT-11 Female Humans irinotecan liposome Liposomes Medical sciences Mice Mice, Inbred BALB C Neoplasms, Experimental - drug therapy Pharmacology. Drug treatments SN-38 Xenograft Model Antitumor Assays Camptothecin derivatives Antineoplastic agent Human Enzyme Treatment efficiency DNA topoisomerase Enzyme inhibitor Liposome Drug carrier Transplantation Malignant tumor Heterotransplantation Irinotecan Isomerases Treatment Surgery Animal Formulation Graft Topoisomerase I inhibitor Cancer
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