Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes
To the Editor: The EMPA-REG OUTCOME trial (Nov. 26 issue) 1 showed relative-risk reductions of 38% in death from cardiovascular causes, 31% in sudden death, and 35% in hospitalization for heart failure with empagliflozin as compared with placebo. The authors briefly speculate about underlying mechan...
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| Published in: | The New England journal of medicine Vol. 374; no. 11; pp. 1092 - 1094 |
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17-03-2016
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| Abstract | To the Editor:
The EMPA-REG OUTCOME trial (Nov. 26 issue)
1
showed relative-risk reductions of 38% in death from cardiovascular causes, 31% in sudden death, and 35% in hospitalization for heart failure with empagliflozin as compared with placebo. The authors briefly speculate about underlying mechanisms. The difference in blood pressure favoring the empagliflozin groups, averaging 4 mm Hg in systolic pressure and 1.5 mm Hg in diastolic pressure (similar to previous data with sodium–glucose cotransporter 2 [SGLT2] inhibitors) and sustained from the first weeks of the trial to its end, cannot be overlooked.
In patients with type 2 diabetes, blood-pressure reduction . . . |
|---|---|
| AbstractList | To the Editor:
The EMPA-REG OUTCOME trial (Nov. 26 issue)
1
showed relative-risk reductions of 38% in death from cardiovascular causes, 31% in sudden death, and 35% in hospitalization for heart failure with empagliflozin as compared with placebo. The authors briefly speculate about underlying mechanisms. The difference in blood pressure favoring the empagliflozin groups, averaging 4 mm Hg in systolic pressure and 1.5 mm Hg in diastolic pressure (similar to previous data with sodium–glucose cotransporter 2 [SGLT2] inhibitors) and sustained from the first weeks of the trial to its end, cannot be overlooked.
In patients with type 2 diabetes, blood-pressure reduction . . . To the Editor: The EMPA-REG OUTCOME trial (Nov. 26 issue)1 showed relative-risk reductions of 38% in death from cardiovascular causes, 31% in sudden death, and 35% in hospitalization for heart failure with empagliflozin as compared with placebo. The authors briefly speculate about underlying mechanisms. The difference in blood pressure favoring the empagliflozin groups, averaging 4 mm Hg in systolic pressure and 1.5 mm Hg in diastolic pressure (similar to previous data with sodium–glucose cotransporter 2 [SGLT2] inhibitors) and sustained from the first weeks of the trial to its end, cannot be overlooked. In patients with type 2 diabetes, blood-pressure reduction . . . |
| Author | Inzucchi, Silvio E Tsapas, Apostolos Fischereder, Michael Edwards, Jonathan L Rosenstein, Robert Hough, Augustus Lachin, John M Sarafidis, Pantelis A Zinman, Bernard Schönermarck, Ulf |
| Author_xml | – sequence: 1 givenname: Pantelis A surname: Sarafidis fullname: Sarafidis, Pantelis A email: psarafidis11@yahoo.gr organization: School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece – sequence: 2 givenname: Apostolos surname: Tsapas fullname: Tsapas, Apostolos email: psarafidis11@yahoo.gr organization: School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece – sequence: 3 givenname: Michael surname: Fischereder fullname: Fischereder, Michael email: michael.fischereder@med.uni-muenchen.de organization: Klinikum der Ludwig Maximilians Universität, Munich, Germany – sequence: 4 givenname: Ulf surname: Schönermarck fullname: Schönermarck, Ulf email: michael.fischereder@med.uni-muenchen.de organization: Klinikum der Ludwig Maximilians Universität, Munich, Germany – sequence: 5 givenname: Jonathan L surname: Edwards fullname: Edwards, Jonathan L email: jedwards@summahealth.org organization: Summa Health System, Akron, OH – sequence: 6 givenname: Robert surname: Rosenstein fullname: Rosenstein, Robert email: augustus.hough@va.gov organization: West Palm Beach Veterans Affairs Medical Center, West Palm Beach, FL – sequence: 7 givenname: Augustus surname: Hough fullname: Hough, Augustus email: augustus.hough@va.gov organization: West Palm Beach Veterans Affairs Medical Center, West Palm Beach, FL – sequence: 8 givenname: Bernard surname: Zinman fullname: Zinman, Bernard email: zinman@lunenfeld.ca organization: University of Toronto, Toronto, ON, Canada – sequence: 9 givenname: John M surname: Lachin fullname: Lachin, John M organization: George Washington University Biostatistics Center, Rockville, MD – sequence: 10 givenname: Silvio E surname: Inzucchi fullname: Inzucchi, Silvio E organization: Yale University School of Medicine, New Haven, CT |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26981940$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1056/NEJM199909023411001 10.1056/NEJMoa1001286 10.1056/NEJMoa1504720 10.1016/S0140-6736(07)61303-8 10.1136/bmj.317.7160.703 10.1056/NEJMsr077003 10.1172/JCI113847 10.1056/NEJMoa0706245 10.1161/CIRCHEARTFAILURE.112.000003 |
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The EMPA-REG OUTCOME trial (Nov. 26 issue)
1
showed relative-risk reductions of 38% in death from cardiovascular causes, 31% in sudden death,... To the Editor: The EMPA-REG OUTCOME trial (Nov. 26 issue)1 showed relative-risk reductions of 38% in death from cardiovascular causes, 31% in sudden death, and... |
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| SubjectTerms | Benzhydryl Compounds - therapeutic use Blood pressure Cardiovascular diseases Cardiovascular Diseases - prevention & control Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - drug therapy Female Glucosides - therapeutic use Health risk assessment Heart diseases Heart failure Humans Hypoglycemic Agents - therapeutic use Male Sodium |
| Title | Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes |
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