A Temporal Map of Transcription Factor Activity: Mef2 Directly Regulates Target Genes at All Stages of Muscle Development
Dissecting components of key transcriptional networks is essential for understanding complex developmental processes and phenotypes. Genetic studies have highlighted the role of members of the Mef2 family of transcription factors as essential regulators in myogenesis from flies to man. To understand...
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| Published in: | Developmental cell Vol. 10; no. 6; pp. 797 - 807 |
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| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Elsevier Inc
01-06-2006
Cell Press |
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| Abstract | Dissecting components of key transcriptional networks is essential for understanding complex developmental processes and phenotypes. Genetic studies have highlighted the role of members of the Mef2 family of transcription factors as essential regulators in myogenesis from flies to man. To understand how these transcription factors control diverse processes in muscle development, we have combined chromatin immunoprecipitation analysis with gene expression profiling to obtain a temporal map of Mef2 activity during
Drosophila embryonic development. This global approach revealed three temporal patterns of Mef2 enhancer binding, providing a glimpse of dynamic enhancer use within the context of a developing embryo. Our results provide mechanistic insight into the regulation of Mef2's activity at the level of DNA binding and suggest cooperativity with the bHLH protein Twist. The number and diversity of new direct target genes indicates a much broader role for Mef2, at all stages of myogenesis, than previously anticipated. |
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| AbstractList | Dissecting components of key transcriptional networks is essential for understanding complex developmental processes and phenotypes. Genetic studies have highlighted the role of members of the Mef2 family of transcription factors as essential regulators in myogenesis from flies to man. To understand how these transcription factors control diverse processes in muscle development, we have combined chromatin immunoprecipitation analysis with gene expression profiling to obtain a temporal map of Mef2 activity during Drosophila embryonic development. This global approach revealed three temporal patterns of Mef2 enhancer binding, providing a glimpse of dynamic enhancer use within the context of a developing embryo. Our results provide mechanistic insight into the regulation of Mef2's activity at the level of DNA binding and suggest cooperativity with the bHLH protein Twist. The number and diversity of new direct target genes indicates a much broader role for Mef2, at all stages of myogenesis, than previously anticipated. Dissecting components of key transcriptional networks is essential for understanding complex developmental processes and phenotypes. Genetic studies have highlighted the role of members of the Mef2 family of transcription factors as essential regulators in myogenesis from flies to man. To understand how these transcription factors control diverse processes in muscle development, we have combined chromatin immunoprecipitation analysis with gene expression profiling to obtain a temporal map of Mef2 activity during Drosophila embryonic development. This global approach revealed three temporal patterns of Mef2 enhancer binding, providing a glimpse of dynamic enhancer use within the context of a developing embryo. Our results provide mechanistic insight into the regulation of Mef2's activity at the level of DNA binding and suggest cooperativity with the bHLH protein Twist. The number and diversity of new direct target genes indicates a much broader role for Mef2, at all stages of myogenesis, than previously anticipated. |
| Author | Eichenlaub, Michael P. Jakobsen, Janus S. Furlong, Eileen E.M. Jensen, Lars J. Karzynski, Michal M. Bork, Peer Sandmann, Thomas |
| Author_xml | – sequence: 1 givenname: Thomas surname: Sandmann fullname: Sandmann, Thomas organization: European Molecular Biology Laboratory, D-69117 Heidelberg, Germany – sequence: 2 givenname: Lars J. surname: Jensen fullname: Jensen, Lars J. organization: European Molecular Biology Laboratory, D-69117 Heidelberg, Germany – sequence: 3 givenname: Janus S. surname: Jakobsen fullname: Jakobsen, Janus S. organization: European Molecular Biology Laboratory, D-69117 Heidelberg, Germany – sequence: 4 givenname: Michal M. surname: Karzynski fullname: Karzynski, Michal M. organization: European Molecular Biology Laboratory, D-69117 Heidelberg, Germany – sequence: 5 givenname: Michael P. surname: Eichenlaub fullname: Eichenlaub, Michael P. organization: European Molecular Biology Laboratory, D-69117 Heidelberg, Germany – sequence: 6 givenname: Peer surname: Bork fullname: Bork, Peer organization: European Molecular Biology Laboratory, D-69117 Heidelberg, Germany – sequence: 7 givenname: Eileen E.M. surname: Furlong fullname: Furlong, Eileen E.M. email: furlong@embl.de organization: European Molecular Biology Laboratory, D-69117 Heidelberg, Germany |
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| Keywords | SYSBIO DNA DEVBIO Development Regulation(control) Muscle Gene Transcription factor |
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| Title | A Temporal Map of Transcription Factor Activity: Mef2 Directly Regulates Target Genes at All Stages of Muscle Development |
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