Probability that there is a mammalian counterpart of cardiac clock in insects

• Published in: Archives of insect biochemistry and physiology Vol. 110; no. 1; pp. e21867 - n/a
• Main Author: Kodirov, Sodikdjon A.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01-05-2022
• Subjects: Animals; Cyclic Nucleotide-Gated Cation Channels; HCN; Heart; Heart rate; Hyperpolarization; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; If channel; Insecta; Insects; Invertebrates; Ion channels; Ion channels (cyclic nucleotide-gated); Mammals; Nucleotides; Probability; Heart rate; HCN; If channel
• ISSN: 0739-4462; 1520-6327
• DOI: 10.1002/arch.21867

Whether or not the hyperpolarization‐activated cyclic nucleotide‐gated nonselective cation channel (HCN or funny current If) is involved in pacemaking − recurrent heartbeat, it is attributed to electrical activities in all excitable cells, including those of invertebrates. In latter group of animals prevailingly the electrical signals and function of heart in terms of chrono‐ and inotropy are elucidated. Although in simpler models including insects experimental outcomes are reproducible and robust, involvement of “cardiac clock” mechanism in pacemaking is not conclusive. In this assay, the mechanisms of heartbeat are synthesized by focused comparisons between insect and mammalian hearts.
Cardiac electrical activities in insects (a) are apparently obliterated by an antagonist (b, left). However, the wash‐out effects are based on a cut, copy and paste of two out of three heartbeats (b, right). The “originality” of recording was achieved additionally by assigning a small “nose” (+). The aforementioned points are substantiated by PowerPoint features (c and d).
Highlights
The HCN channels are crucial for the electrical rhythm of select and dedicated cells within the brain and heart. But not always are involved in pacemaking per se.