Patients With Apparently Nonfunctioning Adrenal Incidentalomas May Be at Increased Cardiovascular Risk Due to Excessive Cortisol Secretion
Context: Although adrenal incidentalomas (AIs) are associated with a high prevalence of cardiovascular risk (CVR) factors, it is not clear whether patients with nonfunctioning AI (NFAI) have increased CVR. Objective: Our objective was to investigate CVR in patients with NFAI. Design and Setting: Thi...
Saved in:
| Published in: | The journal of clinical endocrinology and metabolism Vol. 99; no. 8; pp. 2754 - 2762 |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Bethesda, MD
Endocrine Society
01-08-2014
Copyright by The Endocrine Society |
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Context:
Although adrenal incidentalomas (AIs) are associated with a high prevalence of cardiovascular risk (CVR) factors, it is not clear whether patients with nonfunctioning AI (NFAI) have increased CVR.
Objective:
Our objective was to investigate CVR in patients with NFAI.
Design and Setting:
This case-control study was performed in a tertiary general hospital.
Subjects:
Subjects included 60 normotensive euglycemic patients with AI and 32 healthy controls (C) with normal adrenal imaging.
Main Outcome Measures:
All participants underwent adrenal imaging, biochemical and hormonal evaluation, and the following investigations: 1) measurement of carotid intima-media thickness (IMT) and flow-mediated dilatation, 2) 2-hour 75-gram oral glucose tolerance test and calculation of insulin resistance indices (homeostasis model assessment, quantitative insulin sensitivity check, and Matsuda indices), 3) iv ACTH stimulation test, 4) low-dose dexamethasone suppression test, and 5) NaCl (0.9%) post-dexamethasone saline infusion test.
Results:
Based on cutoffs obtained from controls, autonomous cortisol secretion was documented in 26 patients (cortisol-secreting AI [CSAI] group), whereas 34 exhibited adequate cortisol and aldosterone suppression (NFAI group). IMT measurements were higher and flow-mediated vasodilatation was lower in the CSAI group compared with both NFAI and C and in the NFAI group compared with C. The homeostasis model assessment index was higher and quantitative insulin sensitivity check index and Matsuda indices were lower in the CSAI and NFAI groups compared with C as well as in CSAI compared with the NFAI group. The area under the curve for cortisol after ACTH stimulation was higher in the CSAI group compared with the NFAI group and C and in the NFAI group compared with C. In the CSAI group, IMT correlated with cortisol, urinary free cortisol, and cortisol after a low-dose dexamethasone suppression test, whereas in the NFAI group, IMT correlated with area under the curve for cortisol after ACTH stimulation and urinary free cortisol.
Conclusions:
Patients with CSAI without hypertension, diabetes, and/or dyslipidemia exhibit adverse metabolic and CVR factors. In addition, NFAIs are apparently associated with increased insulin resistance and endothelial dysfunction that correlate with subtle but not autonomous cortisol excess. |
|---|---|
| AbstractList | CONTEXT:Although adrenal incidentalomas (AIs) are associated with a high prevalence of cardiovascular risk (CVR) factors, it is not clear whether patients with nonfunctioning AI (NFAI) have increased CVR.
OBJECTIVE:Our objective was to investigate CVR in patients with NFAI.
DESIGN AND SETTING:This case-control study was performed in a tertiary general hospital.
SUBJECTS:Subjects included 60 normotensive euglycemic patients with AI and 32 healthy controls (C) with normal adrenal imaging.
MAIN OUTCOME MEASURES:All participants underwent adrenal imaging, biochemical and hormonal evaluation, and the following investigations1) measurement of carotid intima-media thickness (IMT) and flow-mediated dilatation, 2) 2-hour 75-gram oral glucose tolerance test and calculation of insulin resistance indices (homeostasis model assessment, quantitative insulin sensitivity check, and Matsuda indices), 3) iv ACTH stimulation test, 4) low-dose dexamethasone suppression test, and 5) NaCl (0.9%) post-dexamethasone saline infusion test.
RESULTS:Based on cutoffs obtained from controls, autonomous cortisol secretion was documented in 26 patients (cortisol-secreting AI [CSAI] group), whereas 34 exhibited adequate cortisol and aldosterone suppression (NFAI group). IMT measurements were higher and flow-mediated vasodilatation was lower in the CSAI group compared with both NFAI and C and in the NFAI group compared with C. The homeostasis model assessment index was higher and quantitative insulin sensitivity check index and Matsuda indices were lower in the CSAI and NFAI groups compared with C as well as in CSAI compared with the NFAI group. The area under the curve for cortisol after ACTH stimulation was higher in the CSAI group compared with the NFAI group and C and in the NFAI group compared with C. In the CSAI group, IMT correlated with cortisol, urinary free cortisol, and cortisol after a low-dose dexamethasone suppression test, whereas in the NFAI group, IMT correlated with area under the curve for cortisol after ACTH stimulation and urinary free cortisol.
CONCLUSIONS:Patients with CSAI without hypertension, diabetes, and/or dyslipidemia exhibit adverse metabolic and CVR factors. In addition, NFAIs are apparently associated with increased insulin resistance and endothelial dysfunction that correlate with subtle but not autonomous cortisol excess. Context: Although adrenal incidentalomas (AIs) are associated with a high prevalence of cardiovascular risk (CVR) factors, it is not clear whether patients with nonfunctioning AI (NFAI) have increased CVR. Objective: Our objective was to investigate CVR in patients with NFAI. Design and Setting: This case-control study was performed in a tertiary general hospital. Subjects: Subjects included 60 normotensive euglycemic patients with AI and 32 healthy controls (C) with normal adrenal imaging. Main Outcome Measures: All participants underwent adrenal imaging, biochemical and hormonal evaluation, and the following investigations: 1) measurement of carotid intima-media thickness (IMT) and flow-mediated dilatation, 2) 2-hour 75-gram oral glucose tolerance test and calculation of insulin resistance indices (homeostasis model assessment, quantitative insulin sensitivity check, and Matsuda indices), 3) iv ACTH stimulation test, 4) low-dose dexamethasone suppression test, and 5) NaCl (0.9%) post-dexamethasone saline infusion test. Results: Based on cutoffs obtained from controls, autonomous cortisol secretion was documented in 26 patients (cortisol-secreting AI [CSAI] group), whereas 34 exhibited adequate cortisol and aldosterone suppression (NFAI group). IMT measurements were higher and flow-mediated vasodilatation was lower in the CSAI group compared with both NFAI and C and in the NFAI group compared with C. The homeostasis model assessment index was higher and quantitative insulin sensitivity check index and Matsuda indices were lower in the CSAI and NFAI groups compared with C as well as in CSAI compared with the NFAI group. The area under the curve for cortisol after ACTH stimulation was higher in the CSAI group compared with the NFAI group and C and in the NFAI group compared with C. In the CSAI group, IMT correlated with cortisol, urinary free cortisol, and cortisol after a low-dose dexamethasone suppression test, whereas in the NFAI group, IMT correlated with area under the curve for cortisol after ACTH stimulation and urinary free cortisol. Conclusions: Patients with CSAI without hypertension, diabetes, and/or dyslipidemia exhibit adverse metabolic and CVR factors. In addition, NFAIs are apparently associated with increased insulin resistance and endothelial dysfunction that correlate with subtle but not autonomous cortisol excess. Although adrenal incidentalomas (AIs) are associated with a high prevalence of cardiovascular risk (CVR) factors, it is not clear whether patients with nonfunctioning AI (NFAI) have increased CVR. Our objective was to investigate CVR in patients with NFAI. This case-control study was performed in a tertiary general hospital. SUBJECTS included 60 normotensive euglycemic patients with AI and 32 healthy controls (C) with normal adrenal imaging. All participants underwent adrenal imaging, biochemical and hormonal evaluation, and the following investigations: 1) measurement of carotid intima-media thickness (IMT) and flow-mediated dilatation, 2) 2-hour 75-gram oral glucose tolerance test and calculation of insulin resistance indices (homeostasis model assessment, quantitative insulin sensitivity check, and Matsuda indices), 3) iv ACTH stimulation test, 4) low-dose dexamethasone suppression test, and 5) NaCl (0.9%) post-dexamethasone saline infusion test. Based on cutoffs obtained from controls, autonomous cortisol secretion was documented in 26 patients (cortisol-secreting AI [CSAI] group), whereas 34 exhibited adequate cortisol and aldosterone suppression (NFAI group). IMT measurements were higher and flow-mediated vasodilatation was lower in the CSAI group compared with both NFAI and C and in the NFAI group compared with C. The homeostasis model assessment index was higher and quantitative insulin sensitivity check index and Matsuda indices were lower in the CSAI and NFAI groups compared with C as well as in CSAI compared with the NFAI group. The area under the curve for cortisol after ACTH stimulation was higher in the CSAI group compared with the NFAI group and C and in the NFAI group compared with C. In the CSAI group, IMT correlated with cortisol, urinary free cortisol, and cortisol after a low-dose dexamethasone suppression test, whereas in the NFAI group, IMT correlated with area under the curve for cortisol after ACTH stimulation and urinary free cortisol. Patients with CSAI without hypertension, diabetes, and/or dyslipidemia exhibit adverse metabolic and CVR factors. In addition, NFAIs are apparently associated with increased insulin resistance and endothelial dysfunction that correlate with subtle but not autonomous cortisol excess. CONTEXTAlthough adrenal incidentalomas (AIs) are associated with a high prevalence of cardiovascular risk (CVR) factors, it is not clear whether patients with nonfunctioning AI (NFAI) have increased CVR.OBJECTIVEOur objective was to investigate CVR in patients with NFAI.DESIGN AND SETTINGThis case-control study was performed in a tertiary general hospital.SUBJECTSSUBJECTS included 60 normotensive euglycemic patients with AI and 32 healthy controls (C) with normal adrenal imaging.MAIN OUTCOME MEASURESAll participants underwent adrenal imaging, biochemical and hormonal evaluation, and the following investigations: 1) measurement of carotid intima-media thickness (IMT) and flow-mediated dilatation, 2) 2-hour 75-gram oral glucose tolerance test and calculation of insulin resistance indices (homeostasis model assessment, quantitative insulin sensitivity check, and Matsuda indices), 3) iv ACTH stimulation test, 4) low-dose dexamethasone suppression test, and 5) NaCl (0.9%) post-dexamethasone saline infusion test.RESULTSBased on cutoffs obtained from controls, autonomous cortisol secretion was documented in 26 patients (cortisol-secreting AI [CSAI] group), whereas 34 exhibited adequate cortisol and aldosterone suppression (NFAI group). IMT measurements were higher and flow-mediated vasodilatation was lower in the CSAI group compared with both NFAI and C and in the NFAI group compared with C. The homeostasis model assessment index was higher and quantitative insulin sensitivity check index and Matsuda indices were lower in the CSAI and NFAI groups compared with C as well as in CSAI compared with the NFAI group. The area under the curve for cortisol after ACTH stimulation was higher in the CSAI group compared with the NFAI group and C and in the NFAI group compared with C. In the CSAI group, IMT correlated with cortisol, urinary free cortisol, and cortisol after a low-dose dexamethasone suppression test, whereas in the NFAI group, IMT correlated with area under the curve for cortisol after ACTH stimulation and urinary free cortisol.CONCLUSIONSPatients with CSAI without hypertension, diabetes, and/or dyslipidemia exhibit adverse metabolic and CVR factors. In addition, NFAIs are apparently associated with increased insulin resistance and endothelial dysfunction that correlate with subtle but not autonomous cortisol excess. |
| Author | Kollias, Georgios E Papamichael, Christos M Kaltsas, Gregory A Hadjidakis, Dimitrios J Thomas, Dimitrios A Markou, Athina C Piaditis, George P Gouli, Aggeliki K Alexandraki, Krystallenia I Androulakis, Ioannis I |
| AuthorAffiliation | Department of Endocrinology and Diabetes (I.I.A., A.C.M., A.K.G., G.P.P.), General Hospital of Athens “G. Gennimatas,” and Endocrine Unit (G.A.K., D.A.T., K.I.A.), Department of Pathophysiology, National University of Athens, 11527 Athens, Greece; Endocrine Unit (I.I.A., D.J.H.), Second Department of Internal Medicine-Propaedeutic, Research Institute and Diabetes Center, Athens University Medical School, Attikon University Hospital, 12462 Athens, Greece; and Vascular Laboratory (G.E.K., C.M.P.), Department of Therapeutics, Alexandra Hospital, School of Medicine, University of Athens, 11528 Athens, Greece |
| AuthorAffiliation_xml | – name: Department of Endocrinology and Diabetes (I.I.A., A.C.M., A.K.G., G.P.P.), General Hospital of Athens “G. Gennimatas,” and Endocrine Unit (G.A.K., D.A.T., K.I.A.), Department of Pathophysiology, National University of Athens, 11527 Athens, Greece; Endocrine Unit (I.I.A., D.J.H.), Second Department of Internal Medicine-Propaedeutic, Research Institute and Diabetes Center, Athens University Medical School, Attikon University Hospital, 12462 Athens, Greece; and Vascular Laboratory (G.E.K., C.M.P.), Department of Therapeutics, Alexandra Hospital, School of Medicine, University of Athens, 11528 Athens, Greece |
| Author_xml | – sequence: 1 givenname: Ioannis I surname: Androulakis fullname: Androulakis, Ioannis I email: iandroulakis@gmail.com – sequence: 2 givenname: Gregory A surname: Kaltsas fullname: Kaltsas, Gregory A – sequence: 3 givenname: Georgios E surname: Kollias fullname: Kollias, Georgios E – sequence: 4 givenname: Athina C surname: Markou fullname: Markou, Athina C – sequence: 5 givenname: Aggeliki K surname: Gouli fullname: Gouli, Aggeliki K – sequence: 6 givenname: Dimitrios A surname: Thomas fullname: Thomas, Dimitrios A – sequence: 7 givenname: Krystallenia I surname: Alexandraki fullname: Alexandraki, Krystallenia I – sequence: 8 givenname: Christos M surname: Papamichael fullname: Papamichael, Christos M – sequence: 9 givenname: Dimitrios J surname: Hadjidakis fullname: Hadjidakis, Dimitrios J – sequence: 10 givenname: George P surname: Piaditis fullname: Piaditis, George P |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28919669$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/24712565$$D View this record in MEDLINE/PubMed |
| BookMark | eNptkUtv1DAQgC1URLeFG2fkCxIHUmzHSZzjdmmhUnmIh-BmOc6Y9dZrBztpu3-BX42jXeCCL5bH38zY35ygIx88IPSUkjPKKHm10WeM0LLgpOYP0IK2vCoa2jZHaEEIo0XbsO_H6CSlDSGU86p8hI4Zbyir6mqBfn1UowU_JvzNjmu8HAYV89Ht8PvgzeT1aIO3_gde9jmuHL7y2vaZUC5sVcLv1A6fA1bjfBFBJejxSsXehluV9ORUxJ9susGvJ8BjwBf3GlKyt4BXIY42BYc_Q86buzxGD41yCZ4c9lP09fLiy-ptcf3hzdVqeV1ozgUtTG86pjphgHeCloYDEyVXgjYVM9S0nPUdiKqvahC17juqK6qEbkQ3RwgpT9GLfd0hhp8TpFFubdLgnPIQpiRpVbGybmpaZ_TlHtUxpBTByCHarYo7SYmc7cuNlrN9OdvP-LND5anbQv8X_qM7A88PQJajnIkq20z_ONHStq7bzPE9dxfcCDHduOkOolyDcuNakrx43Ygid-Ykf4kUZB51Tiv3aeD7oKP1MMSsW27CFPPs0v9f_RsXtLGD |
| CODEN | JCEMAZ |
| CitedBy_id | crossref_primary_10_1007_s42000_021_00308_z crossref_primary_10_1530_EJE_16_0467 crossref_primary_10_1111_cen_14861 crossref_primary_10_3389_fendo_2024_1385808 crossref_primary_10_1016_j_eprac_2022_11_009 crossref_primary_10_1111_cen_14745 crossref_primary_10_1530_EJE_14_0537 crossref_primary_10_3390_ijms23020673 crossref_primary_10_1038_s41588_021_00852_9 crossref_primary_10_3390_ijms23084340 crossref_primary_10_1007_s42000_022_00406_6 crossref_primary_10_1210_en_2016_1804 crossref_primary_10_1016_j_ecl_2015_02_009 crossref_primary_10_1093_ejendo_lvad134 crossref_primary_10_1210_jc_2017_00823 crossref_primary_10_1016_j_coemr_2019_08_019 crossref_primary_10_1111_cen_13294 crossref_primary_10_7326_M18_3630 crossref_primary_10_1016_j_med_2023_12_002 crossref_primary_10_1210_jc_2014_3541 crossref_primary_10_4158_EP_2020_0182 crossref_primary_10_1002_ijc_29950 crossref_primary_10_1111_cen_14850 crossref_primary_10_1186_s12893_016_0154_1 crossref_primary_10_1016_j_beem_2020_101427 crossref_primary_10_1111_cen_14811 crossref_primary_10_1007_s40137_016_0145_2 crossref_primary_10_1016_j_ando_2023_01_005 crossref_primary_10_1038_s41598_022_19321_2 crossref_primary_10_4158_EP171897_CR crossref_primary_10_1007_s00330_019_06202_y crossref_primary_10_1080_17446651_2018_1543585 crossref_primary_10_1055_a_1827_4113 crossref_primary_10_1210_js_2019_00090 crossref_primary_10_4158_EP161713_OR crossref_primary_10_1007_s12020_017_1400_8 crossref_primary_10_1007_s12020_018_1696_z crossref_primary_10_1186_s12933_023_01836_1 crossref_primary_10_2174_1871530318666181009112042 crossref_primary_10_3390_biomedicines11123115 crossref_primary_10_1007_s12020_017_1421_3 crossref_primary_10_1186_s12933_022_01451_6 crossref_primary_10_1007_s12020_019_02066_w crossref_primary_10_1093_ejendo_lvad066 crossref_primary_10_1001_jamanetworkopen_2024_6453 crossref_primary_10_1007_s12020_023_03396_6 crossref_primary_10_1016_j_beem_2021_101494 crossref_primary_10_1080_17446651_2021_1948327 crossref_primary_10_1210_js_2018_00385 crossref_primary_10_1007_s12020_020_02212_9 crossref_primary_10_1016_j_diabres_2024_111099 crossref_primary_10_1016_j_tem_2015_07_010 crossref_primary_10_1097_MED_0000000000000151 crossref_primary_10_1507_endocrj_EJ18_0066 crossref_primary_10_1097_MED_0000000000000153 crossref_primary_10_1002_jso_27594 crossref_primary_10_3390_medicina56020069 crossref_primary_10_1111_cen_12823 crossref_primary_10_1007_s12020_017_1439_6 crossref_primary_10_1007_s12020_021_02741_x crossref_primary_10_1210_jc_2018_01029 crossref_primary_10_1007_s40618_017_0644_8 crossref_primary_10_1016_j_jdiacomp_2016_05_006 crossref_primary_10_4158_EP_2019_0047 crossref_primary_10_1530_EC_22_0074 crossref_primary_10_1210_jc_2018_02790 crossref_primary_10_3390_jcm12144612 crossref_primary_10_1097_MED_0000000000000628 crossref_primary_10_1093_ejendo_lvad113 crossref_primary_10_1007_s12020_022_03120_w crossref_primary_10_1210_clinem_dgad074 crossref_primary_10_3390_jcm12134244 crossref_primary_10_1210_jendso_bvaa079 crossref_primary_10_3109_07435800_2015_1076455 crossref_primary_10_1530_EJE_17_0986 crossref_primary_10_1038_s41371_017_0011_4 crossref_primary_10_1038_s41598_023_48295_y crossref_primary_10_1001_jamainternmed_2023_5698 crossref_primary_10_1007_s40618_021_01615_3 crossref_primary_10_1007_s40619_022_01148_8 crossref_primary_10_1111_cen_13822 crossref_primary_10_1155_2015_674734 crossref_primary_10_1210_clinem_dgad665 crossref_primary_10_1007_s11845_021_02734_9 crossref_primary_10_1111_cen_13541 crossref_primary_10_1530_EJE_15_0272 crossref_primary_10_1016_j_steroids_2018_08_011 crossref_primary_10_4158_EP14399_OR crossref_primary_10_1530_EJE_15_0354 |
| Cites_doi | 10.1016/j.metabol.2010.01.007 10.1016/S0735-1097(01)01746-6 10.1046/j.1365-2362.2000.0300s3083.x 10.1161/circ.106.25.3143 10.1007/BF03344099 10.1007/BF03345772 10.1093/qjmed/hcm118 10.2147/vhrm.2006.2.1.19 10.4149/neo_2009_06_521 10.7326/0003-4819-128-4-199802150-00002 10.1007/BF03346410 10.1159/000314319 10.1097/SLA.0b013e31819a47d2 10.1530/EJE-10-1147 10.1210/jc.2010-2722 10.1210/jcem.87.3.8277 10.1016/S0735-1097(99)00259-4 10.1530/EJE-11-1039 10.1210/er.2002-0031 10.1016/0735-1097(95)00327-4 10.1172/JCI112886 10.1001/jama.2013.284427 10.1016/j.metabol.2006.12.018 10.1530/eje.0.1480213 10.1111/j.1365-2265.2008.03492.x 10.1530/EJE-08-0707 10.1007/s12020-009-9160-8 10.1210/jcem-20-12-1539 10.1530/eje.0.1490273 10.1210/jc.2001-011766 10.1046/j.1365-2265.2000.01006.x 10.1210/jc.2009-2387 10.1007/BF03347083 10.1056/NEJMcp065470 10.1007/BF03345724 10.1210/jcem.85.7.6661 10.2337/dc13-S011 10.1111/j.1365-2796.2010.02291.x 10.2337/diacare.22.9.1462 10.1111/j.1365-2265.2009.03551.x 10.1210/jc.2010-0633 10.1159/000314272 |
| ContentType | Journal Article |
| Copyright | Copyright © 2014 by the Endocrine Society Copyright © 2014 by The Endocrine Society 2015 INIST-CNRS |
| Copyright_xml | – notice: Copyright © 2014 by the Endocrine Society – notice: Copyright © 2014 by The Endocrine Society – notice: 2015 INIST-CNRS |
| DBID | IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
| DOI | 10.1210/jc.2013-4064 |
| DatabaseName | Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1945-7197 |
| EndPage | 2762 |
| ExternalDocumentID | 10_1210_jc_2013_4064 24712565 28919669 00004678-201408000-00021 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | - 02 08R 0R 1TH 29K 2WC 34G 39C 3O- 3V. 4.4 48X 53G 55 5GY 5RS 5YH 7X7 88E 8F7 8FI 8FJ AABJS AABMN AAIMJ AAJQQ AAPQZ AAQQT AAUQX AAWTL AAYJJ ABFLS ABOCM ABPMR ABPPZ ABSAR ABUWG ACGFS ACIMA ACPRK ACUTJ ADBBV ADBIT ADEIU ADGZP ADHKW ADRTK AELNO AELWJ AEMDU AENEX AENZO AETBJ AEWNT AFCHL AFFNX AFKRA AFRAH AFXEN AGINJ AGKRT AGVJH AHMBA AIKOY AIMBJ ALMA_UNASSIGNED_HOLDINGS APIBT AQKUS ARIXL ASMCH ASPBG AVWKF AYOIW AZFZN AZQFJ BAWUL BAYMD BBAFP BCRHZ BENPR BEYMZ BGYMP BHONS BPHCQ BSWAC BTRTY BVXVI C45 CDBKE CS3 D-I DAKXR DIK DPPUQ E3Z EBS EIHJH EJD ENERS F5P FEDTE FH7 FHSFR FOTVD FQBLK FYUFA G8K GAUVT GJ GJXCC GX1 H1 H13 HVGLF HZ H~9 IAO IHR INH J5H KBUDW KOP KQ8 KSN L7B M1P M5 MBLQV MHKGH N9A NLBLG NOYVH NVLIB O0- O9- OBH OCB ODMLO OGEVE OK1 OVD P2P PQEST PQQKQ PQUKI PRINS PROAC PSQYO REU ROX ROZ TCN TJX TLC TMA TWZ VH1 WOQ X X52 X7M XZ ZA5 ZGI ZXP ZY1 .XZ 3RD AJYGW M2M M5~ ROL ~H1 --- -~X .55 .GJ 08P 0R~ 18M 354 AABZA AACZT AAKAS AAPGJ AAVAP AAWDT ABBLC ABLJU ABPTD ABWST ACFRR ACGFO ADGIM ADGKP ADMTO ADVEK ADZCM AERZD AFFZL AFGWE AFOFC AFXAL AGQXC AGUTN AI. AJEEA AQDSO BYORX EMOBN FECEO FOEOM HZ~ IQODW KSI MJL N4W N95 NOMLY OFXIZ OHH OVIDX P6G TEORI TR2 VVN W8F WHG YBU YFH YHG YOC YSK ~02 AAPXW AARHZ AAUAY ABJNI ABMNT ABNHQ ABPQP ABQNK ABXVV ACYHN ACZBC ADQBN AFYAG AGMDO APJGH ATGXG AVNTJ CGR CUY CVF ECM EIF FLUFQ ITC NPM OAUYM OJZSN OPAEJ AAYXX ABEJV CITATION 7X8 |
| ID | FETCH-LOGICAL-c4481-fdfb2ab8fe4b813f4e2834a81752f1f942dbe85d56e86cdb1c51a8c78b56e8003 |
| ISSN | 0021-972X |
| IngestDate | Fri Oct 25 21:46:26 EDT 2024 Thu Nov 21 23:45:08 EST 2024 Sat Sep 28 08:00:53 EDT 2024 Fri Nov 25 01:02:28 EST 2022 Thu Aug 13 19:51:00 EDT 2020 Tue Jan 05 21:44:43 EST 2021 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 8 |
| Keywords | Endocrinopathy Human Corticosteroid Obesity Nutrition Steroid hormone Secretion Adrenal gland neoplasm Nutrition disorder Antiinflammatory agent Patient Metabolic diseases Cardiovascular disease Cortisol Hydrocortisone Glucocorticoid Adrenal hormone Adrenal gland diseases Risk factor Cardiovascular risk Endocrinology Nutritional status |
| Language | English |
| License | CC BY 4.0 |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c4481-fdfb2ab8fe4b813f4e2834a81752f1f942dbe85d56e86cdb1c51a8c78b56e8003 |
| Notes | Part of this project was funded by University of Athens, Special Account for Research Grants (Kapodistrias). ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://academic.oup.com/jcem/article-pdf/99/8/2754/9049328/jcem2754.pdf |
| PMID | 24712565 |
| PQID | 1552367616 |
| PQPubID | 23479 |
| PageCount | 9 |
| ParticipantIDs | proquest_miscellaneous_1552367616 crossref_primary_10_1210_jc_2013_4064 pubmed_primary_24712565 pascalfrancis_primary_28919669 wolterskluwer_health_00004678-201408000-00021 endocrinepress_journals_10_1210_jc_2013_4064 |
| ProviderPackageCode | .XZ OBH C45 5RS AFCHL OGEVE ~H1 ABPMR M5~ OVD OCB |
| PublicationCentury | 2000 |
| PublicationDate | 2014-August |
| PublicationDateYYYYMMDD | 2014-08-01 |
| PublicationDate_xml | – month: 08 year: 2014 text: 2014-August |
| PublicationDecade | 2010 |
| PublicationPlace | Bethesda, MD |
| PublicationPlace_xml | – name: Bethesda, MD – name: United States |
| PublicationTitle | The journal of clinical endocrinology and metabolism |
| PublicationTitleAlternate | J Clin Endocrinol Metab |
| PublicationYear | 2014 |
| Publisher | Endocrine Society Copyright by The Endocrine Society |
| Publisher_xml | – name: Endocrine Society – name: Copyright by The Endocrine Society |
| References | Chiodini, I (B35) 2011; 96 Bovio, S; Cataldi, A; Reimondo, G (B4) 2006; 29 (B5) 2002; 19 Vassilatou, E; Vryonidou, A; Michalopoulou, S (B37) 2009; 70 Mansmann, G; Lau, J; Balk, E; Rothberg, M; Miyachi, Y; Bornstein, SR (B1) 2004; 25 Garrapa, GG; Pantanetti, P; Arnaldi, G; Mantero, F; Faloia, E (B9) 2001; 86 Yilmaz, H; Tütüncü, NB; Sahin, M (B13) 2009; 32 Bernini, G; Moretti, A; Iacconi, P (B8) 2003; 148 Young, WF (B6) 2007; 356 Yener, S; Comlekci, A; Akinci, B (B19) 2009; 32 Chiodini, I; Morelli, V; Salcuni, AS (B42) 2010; 95 Anderson, TJ; Uehata, A; Gerhard, MD (B20) 1995; 26 Barzon, L; Sonino, N; Fallo, F; Palu, G; Boscaro, M (B3) 2003; 149 Pivonello, R; De Leo, M; Vitale, P (B38) 2010; 92 Stewart, PM (B45) 2010; 95 Beuschlein, F; Borgemeister, M; Schirra, J (B40) 2000; 52 (B25) 2002; 106 Tauchmanovà, L; Rossi, R; Biondi, B (B34) 2002; 87 Rossi, R; Tauchmanova, L; Luciano, A (B7) 2000; 85 Terzolo, M; Stigliano, A; Chiodini, I (B2) 2011; 164 Piaditis, GP; Kaltsas, GA; Androulakis, II (B32) 2009; 71 James, PA; Oparil, S; Carter, BL (B24) 2014; 311 Liddle, GW (B31) 1960; 20 Yener, S; Baris, M; Secil, M; Akinci, B; Comlekci, A; Yesil, S (B16) 2011; 34 Katz, A; Nambi, SS; Mather, K (B29) 2000; 85 Di Dalmazi, G; Vicennati, V; Rinaldi, E (B36) 2012; 166 Bergman, RN; Prager, R; Volund, A; Olefsky, JM (B28) 1987; 79 Sereg, M; Szappanos, A; Toke, J (B44) 2009; 160 Terzolo, M; Pia, A; Alì, A (B10) 2002; 87 Peppa, M; Koliaki, C; Raptis, SA (B11) 2010; 268 Matsuda, M; DeFronzo, RA (B30) 1999; 22 Alexandraki, KI; Makras, P; Protogerou, AD (B26) 2008; 101 Corretti, MC; Anderson, TJ; Benjamin, EJ (B27) 2002; 39 Wagnerova, H; Dudasova, D; Lazurova, I (B14) 2009; 56 Yener, S; Genc, S; Akinci, B (B15) 2009; 35 Anderson, TJ (B22) 1999; 34 Toniato, A; Merante-Boschin, I; Opocher, G; Pelizzo, MR; Schiavi, F; Ballotta, E (B43) 2009; 249 Ermetici, F; Malavazos, AE; Corbetta, S (B18) 2007; 56 Ermetici, F; Dall'Asta, C; Malavazos, AE (B17) 2008; 31 Peppa, M; Boutati, E; Koliaki, C (B12) 2010; 59 Lane, HA; Smith, JC; Davies, JS (B23) 2006; 2 (B33) 2013; 36 Dall'Asta, C; Barbetta, L; Libé, R; Passini, E; Ambrosi, B (B39) 2002; 57 Chanson, P; Salenave, S (B46) 2010; 92 Maser-Gluth, C; Reincke, M; Allolio, B; Schulze, E (B41) 2000; 30 Hodis, HN; Mack, WJ; LaBree, L (B21) 1998; 128 25539001 - J Clin Endocrinol Metab. 2014 Nov;99(11):L3 25539000 - J Clin Endocrinol Metab. 2014 Nov;99(11):L1-2 Terzolo (2020071613511828800_B2) 2011; 164 Piaditis (2020071613511828800_B32) 2009; 71 Young (2020071613511828800_B6) 2007; 356 Bergman (2020071613511828800_B28) 1987; 79 Peppa (2020071613511828800_B12) 2010; 59 Corretti (2020071613511828800_B27) 2002; 39 Pivonello (2020071613511828800_B38) 2010; 92 Liddle (2020071613511828800_B31) 1960; 20 Ermetici (2020071613511828800_B17) 2008; 31 Anderson (2020071613511828800_B22) 1999; 34 Garrapa (2020071613511828800_B9) 2001; 86 Beuschlein (2020071613511828800_B40) 2000; 52 Terzolo (2020071613511828800_B10) 2002; 87 Yener (2020071613511828800_B16) 2011; 34 Yener (2020071613511828800_B19) 2009; 32 Mansmann (2020071613511828800_B1) 2004; 25 Maser-Gluth (2020071613511828800_B41) 2000; 30 James (2020071613511828800_B24) 2014; 311 Di Dalmazi (2020071613511828800_B36) 2012; 166 (2020071613511828800_B5) 2002; 19 Bovio (2020071613511828800_B4) 2006; 29 Hodis (2020071613511828800_B21) 1998; 128 Rossi (2020071613511828800_B7) 2000; 85 American Diabetes Association (2020071613511828800_B33) 2013; 36 Alexandraki (2020071613511828800_B26) 2008; 101 Chiodini (2020071613511828800_B35) 2011; 96 Vassilatou (2020071613511828800_B37) 2009; 70 Barzon (2020071613511828800_B3) 2003; 149 Yener (2020071613511828800_B15) 2009; 35 Toniato (2020071613511828800_B43) 2009; 249 Ermetici (2020071613511828800_B18) 2007; 56 Chanson (2020071613511828800_B46) 2010; 92 Bernini (2020071613511828800_B8) 2003; 148 Tauchmanovà (2020071613511828800_B34) 2002; 87 Anderson (2020071613511828800_B20) 1995; 26 Chiodini (2020071613511828800_B42) 2010; 95 Dall'Asta (2020071613511828800_B39) 2002; 57 Yilmaz (2020071613511828800_B13) 2009; 32 Wagnerova (2020071613511828800_B14) 2009; 56 Matsuda (2020071613511828800_B30) 1999; 22 Stewart (2020071613511828800_B45) 2010; 95 National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) (2020071613511828800_B25) 2002; 106 Peppa (2020071613511828800_B11) 2010; 268 Katz (2020071613511828800_B29) 2000; 85 Lane (2020071613511828800_B23) 2006; 2 Sereg (2020071613511828800_B44) 2009; 160 |
| References_xml | – volume: 19 start-page: 1 year: 2002 end-page: 25 ident: B5 article-title: NIH state-of-the-science statement on management of the clinically inapparent adrenal mass (“incidentaloma”) publication-title: NIH Consens State Sci Statements – volume: 86 start-page: 5301 year: 2001 end-page: 5306 ident: B9 article-title: Body composition and metabolic features in women with adrenal incidentaloma or Cushing's syndrome publication-title: J Clin Endocrinol Metab contributor: fullname: Garrapa, GG; Pantanetti, P; Arnaldi, G; Mantero, F; Faloia, E – volume: 22 start-page: 1462 year: 1999 end-page: 1470 ident: B30 article-title: Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp publication-title: Diabetes Care contributor: fullname: Matsuda, M; DeFronzo, RA – volume: 356 start-page: 601 year: 2007 end-page: 610 ident: B6 article-title: Clinical practice. The incidentally discovered adrenal mass publication-title: N Engl J Med contributor: fullname: Young, WF – volume: 32 start-page: 338 year: 2009 end-page: 343 ident: B19 article-title: Non-functioning adrenal incidentalomas are associated with elevated D-dimer levels publication-title: J Endocrinol Invest contributor: fullname: Yener, S; Comlekci, A; Akinci, B – volume: 101 start-page: 31 year: 2008 end-page: 40 ident: B26 article-title: Cardiovascular risk factors in adult patients with multisystem Langerhans-cell histiocytosis: evidence of glucose metabolism abnormalities publication-title: QJM contributor: fullname: Alexandraki, KI; Makras, P; Protogerou, AD – volume: 30 start-page: 83 year: 2000 end-page: 86 ident: B41 article-title: Metabolism of glucocorticoids and mineralocorticoids in patients with adrenal incidentalomas publication-title: Eur J Clin Invest contributor: fullname: Maser-Gluth, C; Reincke, M; Allolio, B; Schulze, E – volume: 34 start-page: 265 year: 2011 end-page: 270 ident: B16 article-title: Is there an association between non-functioning adrenal adenoma and endothelial dysfunction? publication-title: J Endocrinol Invest contributor: fullname: Yener, S; Baris, M; Secil, M; Akinci, B; Comlekci, A; Yesil, S – volume: 56 start-page: 686 year: 2007 end-page: 692 ident: B18 article-title: Adipokine levels and cardiovascular risk in patients with adrenal incidentaloma publication-title: Metabolism contributor: fullname: Ermetici, F; Malavazos, AE; Corbetta, S – volume: 36 start-page: S11 year: 2013 end-page: S66 ident: B33 article-title: Standards of medical care in diabetes–2013 publication-title: Diabetes Care – volume: 106 start-page: 3143 year: 2002 end-page: 3421 ident: B25 article-title: Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report publication-title: Circulation – volume: 92 start-page: 96 year: 2010 end-page: 101 ident: B46 article-title: Metabolic syndrome in Cushing's syndrome publication-title: Neuroendocrinology contributor: fullname: Chanson, P; Salenave, S – volume: 32 start-page: 913 year: 2009 end-page: 916 ident: B13 article-title: Two-year follow-up of thirty-two non-functional benign adrenal incidentalomas publication-title: J Endocrinol Invest contributor: fullname: Yilmaz, H; Tütüncü, NB; Sahin, M – volume: 57 start-page: 192 year: 2002 end-page: 196 ident: B39 article-title: Coexistence of 21-hydroxylase and 11 beta-hydroxylase deficiency in adrenal incidentalomas and in subclinical Cushing's syndrome publication-title: Horm Res contributor: fullname: Dall'Asta, C; Barbetta, L; Libé, R; Passini, E; Ambrosi, B – volume: 71 start-page: 772 year: 2009 end-page: 778 ident: B32 article-title: High prevalence of autonomous cortisol and aldosterone secretion from adrenal adenomas publication-title: Clin Endocrinol (Oxf) contributor: fullname: Piaditis, GP; Kaltsas, GA; Androulakis, II – volume: 70 start-page: 674 year: 2009 end-page: 679 ident: B37 article-title: Hormonal activity of adrenal incidentalomas: results from a long-term follow-up study publication-title: Clin Endocrinol (Oxf) contributor: fullname: Vassilatou, E; Vryonidou, A; Michalopoulou, S – volume: 92 start-page: 77 year: 2010 end-page: 81 ident: B38 article-title: Pathophysiology of diabetes mellitus in Cushing's syndrome publication-title: Neuroendocrinology contributor: fullname: Pivonello, R; De Leo, M; Vitale, P – volume: 35 start-page: 365 year: 2009 end-page: 370 ident: B15 article-title: Carotid intima media thickness is increased and associated with morning cortisol in subjects with non-functioning adrenal incidentaloma publication-title: Endocrine contributor: fullname: Yener, S; Genc, S; Akinci, B – volume: 59 start-page: 1435 year: 2010 end-page: 1441 ident: B12 article-title: Insulin resistance and metabolic syndrome in patients with nonfunctioning adrenal incidentalomas: a cause-effect relationship? publication-title: Metabolism contributor: fullname: Peppa, M; Boutati, E; Koliaki, C – volume: 311 start-page: 507 year: 2014 end-page: 520 ident: B24 article-title: 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8) publication-title: JAMA contributor: fullname: James, PA; Oparil, S; Carter, BL – volume: 166 start-page: 669 year: 2012 end-page: 677 ident: B36 article-title: Progressively increased patterns of subclinical cortisol hypersecretion in adrenal incidentalomas differently predict major metabolic and cardiovascular outcomes: a large cross-sectional study publication-title: Eur J Endocrinol contributor: fullname: Di Dalmazi, G; Vicennati, V; Rinaldi, E – volume: 95 start-page: 2618 year: 2010 end-page: 2620 ident: B45 article-title: Is subclinical Cushing's syndrome an entity or a statistical fallout from diagnostic testing? Consensus surrounding the diagnosis is required before optimal treatment can be defined publication-title: J Clin Endocrinol Metab contributor: fullname: Stewart, PM – volume: 31 start-page: 573 year: 2008 end-page: 577 ident: B17 article-title: Echocardiographic alterations in patients with non-functioning adrenal incidentaloma publication-title: J Endocrinol Invest contributor: fullname: Ermetici, F; Dall'Asta, C; Malavazos, AE – volume: 95 start-page: 2736 year: 2010 end-page: 2745 ident: B42 article-title: Beneficial metabolic effects of prompt surgical treatment in patients with an adrenal incidentaloma causing biochemical hypercortisolism publication-title: J Clin Endocrinol Metab contributor: fullname: Chiodini, I; Morelli, V; Salcuni, AS – volume: 79 start-page: 790 year: 1987 end-page: 800 ident: B28 article-title: Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp publication-title: J Clin Invest contributor: fullname: Bergman, RN; Prager, R; Volund, A; Olefsky, JM – volume: 96 start-page: 1223 year: 2011 end-page: 1236 ident: B35 article-title: Clinical review: Diagnosis and treatment of subclinical hypercortisolism publication-title: J Clin Endocrinol Metab contributor: fullname: Chiodini, I – volume: 34 start-page: 631 year: 1999 end-page: 638 ident: B22 article-title: Assessment and treatment of endothelial dysfunction in humans publication-title: J Am Coll Cardiol contributor: fullname: Anderson, TJ – volume: 160 start-page: 647 year: 2009 end-page: 655 ident: B44 article-title: Atherosclerotic risk factors and complications in patients with non-functioning adrenal adenomas treated with or without adrenalectomy: a long-term follow-up study publication-title: Eur J Endocrinol contributor: fullname: Sereg, M; Szappanos, A; Toke, J – volume: 148 start-page: 213 year: 2003 end-page: 219 ident: B8 article-title: Anthropometric, haemodynamic, humoral and hormonal evaluation in patients with incidental adrenocortical adenomas before and after surgery publication-title: Eur J Endocrinol contributor: fullname: Bernini, G; Moretti, A; Iacconi, P – volume: 85 start-page: 2402 year: 2000 end-page: 2410 ident: B29 article-title: Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans publication-title: J Clin Endocrinol Metab contributor: fullname: Katz, A; Nambi, SS; Mather, K – volume: 87 start-page: 4872 year: 2002 end-page: 4878 ident: B34 article-title: Patients with subclinical Cushing's syndrome due to adrenal adenoma have increased cardiovascular risk publication-title: J Clin Endocrinol Metab contributor: fullname: Tauchmanovà, L; Rossi, R; Biondi, B – volume: 20 start-page: 1539 year: 1960 end-page: 1560 ident: B31 article-title: Tests of pituitary-adrenal suppressibility in the diagnosis of Cushing's syndrome publication-title: J Clin Endocrinol Metab contributor: fullname: Liddle, GW – volume: 128 start-page: 262 year: 1998 end-page: 269 ident: B21 article-title: The role of carotid arterial intima-media thickness in predicting clinical coronary events publication-title: Ann Intern Med contributor: fullname: Hodis, HN; Mack, WJ; LaBree, L – volume: 26 start-page: 1235 year: 1995 end-page: 1241 ident: B20 article-title: Close relation of endothelial function in the human coronary and peripheral circulations publication-title: J Am Coll Cardiol contributor: fullname: Anderson, TJ; Uehata, A; Gerhard, MD – volume: 2 start-page: 19 year: 2006 end-page: 30 ident: B23 article-title: Noninvasive assessment of preclinical atherosclerosis publication-title: Vasc Health Risk Manag contributor: fullname: Lane, HA; Smith, JC; Davies, JS – volume: 85 start-page: 1440 year: 2000 end-page: 1448 ident: B7 article-title: Subclinical Cushing's syndrome in patients with adrenal incidentaloma: clinical and biochemical features publication-title: J Clin Endocrinol Metab contributor: fullname: Rossi, R; Tauchmanova, L; Luciano, A – volume: 25 start-page: 309 year: 2004 end-page: 340 ident: B1 article-title: The clinically inapparent adrenal mass: update in diagnosis and management publication-title: Endocr Rev contributor: fullname: Mansmann, G; Lau, J; Balk, E; Rothberg, M; Miyachi, Y; Bornstein, SR – volume: 164 start-page: 851 year: 2011 end-page: 870 ident: B2 article-title: AME position statement on adrenal incidentaloma publication-title: Eur J Endocrinol contributor: fullname: Terzolo, M; Stigliano, A; Chiodini, I – volume: 149 start-page: 273 year: 2003 end-page: 285 ident: B3 article-title: Prevalence and natural history of adrenal incidentalomas publication-title: Eur J Endocrinol contributor: fullname: Barzon, L; Sonino, N; Fallo, F; Palu, G; Boscaro, M – volume: 39 start-page: 257 year: 2002 end-page: 265 ident: B27 article-title: Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force publication-title: J Am Coll Cardiol contributor: fullname: Corretti, MC; Anderson, TJ; Benjamin, EJ – volume: 249 start-page: 388 year: 2009 end-page: 391 ident: B43 article-title: Surgical versus conservative management for subclinical Cushing syndrome in adrenal incidentalomas: a prospective randomized study publication-title: Ann Surg contributor: fullname: Toniato, A; Merante-Boschin, I; Opocher, G; Pelizzo, MR; Schiavi, F; Ballotta, E – volume: 29 start-page: 298 year: 2006 end-page: 302 ident: B4 article-title: Prevalence of adrenal incidentaloma in a contemporary computerized tomography series publication-title: J Endocrinol Invest contributor: fullname: Bovio, S; Cataldi, A; Reimondo, G – volume: 52 start-page: 617 year: 2000 end-page: 623 ident: B40 article-title: Oral glucose tolerance testing but not intravenous glucose administration uncovers hyper-responsiveness of hypothalamo-pituitary-adrenal axis in patients with adrenal incidentalomas publication-title: Clin Endocrinol (Oxf) contributor: fullname: Beuschlein, F; Borgemeister, M; Schirra, J – volume: 87 start-page: 998 year: 2002 end-page: 1003 ident: B10 article-title: Adrenal incidentaloma: a new cause of the metabolic syndrome? publication-title: J Clin Endocrinol Metab contributor: fullname: Terzolo, M; Pia, A; Alì, A – volume: 56 start-page: 521 year: 2009 end-page: 525 ident: B14 article-title: Hormonal and metabolic evaluation of adrenal incidentalomas publication-title: Neoplasma contributor: fullname: Wagnerova, H; Dudasova, D; Lazurova, I – volume: 268 start-page: 555 year: 2010 end-page: 566 ident: B11 article-title: Adrenal incidentalomas and cardiometabolic morbidity: an emerging association with serious clinical implications publication-title: J Intern Med contributor: fullname: Peppa, M; Koliaki, C; Raptis, SA – volume: 59 start-page: 1435 year: 2010 ident: 2020071613511828800_B12 article-title: Insulin resistance and metabolic syndrome in patients with nonfunctioning adrenal incidentalomas: a cause-effect relationship? publication-title: Metabolism doi: 10.1016/j.metabol.2010.01.007 contributor: fullname: Peppa – volume: 39 start-page: 257 year: 2002 ident: 2020071613511828800_B27 article-title: Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force publication-title: J Am Coll Cardiol doi: 10.1016/S0735-1097(01)01746-6 contributor: fullname: Corretti – volume: 30 start-page: 83 year: 2000 ident: 2020071613511828800_B41 article-title: Metabolism of glucocorticoids and mineralocorticoids in patients with adrenal incidentalomas publication-title: Eur J Clin Invest doi: 10.1046/j.1365-2362.2000.0300s3083.x contributor: fullname: Maser-Gluth – volume: 106 start-page: 3143 year: 2002 ident: 2020071613511828800_B25 article-title: Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report publication-title: Circulation doi: 10.1161/circ.106.25.3143 contributor: fullname: National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) – volume: 29 start-page: 298 year: 2006 ident: 2020071613511828800_B4 article-title: Prevalence of adrenal incidentaloma in a contemporary computerized tomography series publication-title: J Endocrinol Invest doi: 10.1007/BF03344099 contributor: fullname: Bovio – volume: 32 start-page: 913 year: 2009 ident: 2020071613511828800_B13 article-title: Two-year follow-up of thirty-two non-functional benign adrenal incidentalomas publication-title: J Endocrinol Invest doi: 10.1007/BF03345772 contributor: fullname: Yilmaz – volume: 101 start-page: 31 year: 2008 ident: 2020071613511828800_B26 article-title: Cardiovascular risk factors in adult patients with multisystem Langerhans-cell histiocytosis: evidence of glucose metabolism abnormalities publication-title: QJM doi: 10.1093/qjmed/hcm118 contributor: fullname: Alexandraki – volume: 2 start-page: 19 year: 2006 ident: 2020071613511828800_B23 article-title: Noninvasive assessment of preclinical atherosclerosis publication-title: Vasc Health Risk Manag doi: 10.2147/vhrm.2006.2.1.19 contributor: fullname: Lane – volume: 56 start-page: 521 year: 2009 ident: 2020071613511828800_B14 article-title: Hormonal and metabolic evaluation of adrenal incidentalomas publication-title: Neoplasma doi: 10.4149/neo_2009_06_521 contributor: fullname: Wagnerova – volume: 128 start-page: 262 year: 1998 ident: 2020071613511828800_B21 article-title: The role of carotid arterial intima-media thickness in predicting clinical coronary events publication-title: Ann Intern Med doi: 10.7326/0003-4819-128-4-199802150-00002 contributor: fullname: Hodis – volume: 31 start-page: 573 year: 2008 ident: 2020071613511828800_B17 article-title: Echocardiographic alterations in patients with non-functioning adrenal incidentaloma publication-title: J Endocrinol Invest doi: 10.1007/BF03346410 contributor: fullname: Ermetici – volume: 92 start-page: 77 year: 2010 ident: 2020071613511828800_B38 article-title: Pathophysiology of diabetes mellitus in Cushing's syndrome publication-title: Neuroendocrinology doi: 10.1159/000314319 contributor: fullname: Pivonello – volume: 249 start-page: 388 year: 2009 ident: 2020071613511828800_B43 article-title: Surgical versus conservative management for subclinical Cushing syndrome in adrenal incidentalomas: a prospective randomized study publication-title: Ann Surg doi: 10.1097/SLA.0b013e31819a47d2 contributor: fullname: Toniato – volume: 19 start-page: 1 year: 2002 ident: 2020071613511828800_B5 article-title: NIH state-of-the-science statement on management of the clinically inapparent adrenal mass (“incidentaloma”) publication-title: NIH Consens State Sci Statements – volume: 164 start-page: 851 year: 2011 ident: 2020071613511828800_B2 article-title: AME position statement on adrenal incidentaloma publication-title: Eur J Endocrinol doi: 10.1530/EJE-10-1147 contributor: fullname: Terzolo – volume: 96 start-page: 1223 year: 2011 ident: 2020071613511828800_B35 article-title: Clinical review: Diagnosis and treatment of subclinical hypercortisolism publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2010-2722 contributor: fullname: Chiodini – volume: 87 start-page: 998 year: 2002 ident: 2020071613511828800_B10 article-title: Adrenal incidentaloma: a new cause of the metabolic syndrome? publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem.87.3.8277 contributor: fullname: Terzolo – volume: 34 start-page: 631 year: 1999 ident: 2020071613511828800_B22 article-title: Assessment and treatment of endothelial dysfunction in humans publication-title: J Am Coll Cardiol doi: 10.1016/S0735-1097(99)00259-4 contributor: fullname: Anderson – volume: 57 start-page: 192 year: 2002 ident: 2020071613511828800_B39 article-title: Coexistence of 21-hydroxylase and 11 beta-hydroxylase deficiency in adrenal incidentalomas and in subclinical Cushing's syndrome publication-title: Horm Res contributor: fullname: Dall'Asta – volume: 166 start-page: 669 year: 2012 ident: 2020071613511828800_B36 article-title: Progressively increased patterns of subclinical cortisol hypersecretion in adrenal incidentalomas differently predict major metabolic and cardiovascular outcomes: a large cross-sectional study publication-title: Eur J Endocrinol doi: 10.1530/EJE-11-1039 contributor: fullname: Di Dalmazi – volume: 25 start-page: 309 year: 2004 ident: 2020071613511828800_B1 article-title: The clinically inapparent adrenal mass: update in diagnosis and management publication-title: Endocr Rev doi: 10.1210/er.2002-0031 contributor: fullname: Mansmann – volume: 26 start-page: 1235 year: 1995 ident: 2020071613511828800_B20 article-title: Close relation of endothelial function in the human coronary and peripheral circulations publication-title: J Am Coll Cardiol doi: 10.1016/0735-1097(95)00327-4 contributor: fullname: Anderson – volume: 79 start-page: 790 year: 1987 ident: 2020071613511828800_B28 article-title: Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp publication-title: J Clin Invest doi: 10.1172/JCI112886 contributor: fullname: Bergman – volume: 311 start-page: 507 year: 2014 ident: 2020071613511828800_B24 article-title: 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8) publication-title: JAMA doi: 10.1001/jama.2013.284427 contributor: fullname: James – volume: 56 start-page: 686 year: 2007 ident: 2020071613511828800_B18 article-title: Adipokine levels and cardiovascular risk in patients with adrenal incidentaloma publication-title: Metabolism doi: 10.1016/j.metabol.2006.12.018 contributor: fullname: Ermetici – volume: 86 start-page: 5301 year: 2001 ident: 2020071613511828800_B9 article-title: Body composition and metabolic features in women with adrenal incidentaloma or Cushing's syndrome publication-title: J Clin Endocrinol Metab contributor: fullname: Garrapa – volume: 148 start-page: 213 year: 2003 ident: 2020071613511828800_B8 article-title: Anthropometric, haemodynamic, humoral and hormonal evaluation in patients with incidental adrenocortical adenomas before and after surgery publication-title: Eur J Endocrinol doi: 10.1530/eje.0.1480213 contributor: fullname: Bernini – volume: 70 start-page: 674 year: 2009 ident: 2020071613511828800_B37 article-title: Hormonal activity of adrenal incidentalomas: results from a long-term follow-up study publication-title: Clin Endocrinol (Oxf) doi: 10.1111/j.1365-2265.2008.03492.x contributor: fullname: Vassilatou – volume: 160 start-page: 647 year: 2009 ident: 2020071613511828800_B44 article-title: Atherosclerotic risk factors and complications in patients with non-functioning adrenal adenomas treated with or without adrenalectomy: a long-term follow-up study publication-title: Eur J Endocrinol doi: 10.1530/EJE-08-0707 contributor: fullname: Sereg – volume: 35 start-page: 365 year: 2009 ident: 2020071613511828800_B15 article-title: Carotid intima media thickness is increased and associated with morning cortisol in subjects with non-functioning adrenal incidentaloma publication-title: Endocrine doi: 10.1007/s12020-009-9160-8 contributor: fullname: Yener – volume: 20 start-page: 1539 year: 1960 ident: 2020071613511828800_B31 article-title: Tests of pituitary-adrenal suppressibility in the diagnosis of Cushing's syndrome publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem-20-12-1539 contributor: fullname: Liddle – volume: 85 start-page: 1440 year: 2000 ident: 2020071613511828800_B7 article-title: Subclinical Cushing's syndrome in patients with adrenal incidentaloma: clinical and biochemical features publication-title: J Clin Endocrinol Metab contributor: fullname: Rossi – volume: 149 start-page: 273 year: 2003 ident: 2020071613511828800_B3 article-title: Prevalence and natural history of adrenal incidentalomas publication-title: Eur J Endocrinol doi: 10.1530/eje.0.1490273 contributor: fullname: Barzon – volume: 87 start-page: 4872 year: 2002 ident: 2020071613511828800_B34 article-title: Patients with subclinical Cushing's syndrome due to adrenal adenoma have increased cardiovascular risk publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2001-011766 contributor: fullname: Tauchmanovà – volume: 52 start-page: 617 year: 2000 ident: 2020071613511828800_B40 article-title: Oral glucose tolerance testing but not intravenous glucose administration uncovers hyper-responsiveness of hypothalamo-pituitary-adrenal axis in patients with adrenal incidentalomas publication-title: Clin Endocrinol (Oxf) doi: 10.1046/j.1365-2265.2000.01006.x contributor: fullname: Beuschlein – volume: 95 start-page: 2736 year: 2010 ident: 2020071613511828800_B42 article-title: Beneficial metabolic effects of prompt surgical treatment in patients with an adrenal incidentaloma causing biochemical hypercortisolism publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2009-2387 contributor: fullname: Chiodini – volume: 34 start-page: 265 year: 2011 ident: 2020071613511828800_B16 article-title: Is there an association between non-functioning adrenal adenoma and endothelial dysfunction? publication-title: J Endocrinol Invest doi: 10.1007/BF03347083 contributor: fullname: Yener – volume: 356 start-page: 601 year: 2007 ident: 2020071613511828800_B6 article-title: Clinical practice. The incidentally discovered adrenal mass publication-title: N Engl J Med doi: 10.1056/NEJMcp065470 contributor: fullname: Young – volume: 32 start-page: 338 year: 2009 ident: 2020071613511828800_B19 article-title: Non-functioning adrenal incidentalomas are associated with elevated D-dimer levels publication-title: J Endocrinol Invest doi: 10.1007/BF03345724 contributor: fullname: Yener – volume: 85 start-page: 2402 year: 2000 ident: 2020071613511828800_B29 article-title: Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem.85.7.6661 contributor: fullname: Katz – volume: 36 start-page: S11 year: 2013 ident: 2020071613511828800_B33 article-title: Standards of medical care in diabetes–2013 publication-title: Diabetes Care doi: 10.2337/dc13-S011 contributor: fullname: American Diabetes Association – volume: 268 start-page: 555 year: 2010 ident: 2020071613511828800_B11 article-title: Adrenal incidentalomas and cardiometabolic morbidity: an emerging association with serious clinical implications publication-title: J Intern Med doi: 10.1111/j.1365-2796.2010.02291.x contributor: fullname: Peppa – volume: 22 start-page: 1462 year: 1999 ident: 2020071613511828800_B30 article-title: Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp publication-title: Diabetes Care doi: 10.2337/diacare.22.9.1462 contributor: fullname: Matsuda – volume: 71 start-page: 772 year: 2009 ident: 2020071613511828800_B32 article-title: High prevalence of autonomous cortisol and aldosterone secretion from adrenal adenomas publication-title: Clin Endocrinol (Oxf) doi: 10.1111/j.1365-2265.2009.03551.x contributor: fullname: Piaditis – volume: 95 start-page: 2618 year: 2010 ident: 2020071613511828800_B45 article-title: Is subclinical Cushing's syndrome an entity or a statistical fallout from diagnostic testing? Consensus surrounding the diagnosis is required before optimal treatment can be defined publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2010-0633 contributor: fullname: Stewart – volume: 92 start-page: 96 year: 2010 ident: 2020071613511828800_B46 article-title: Metabolic syndrome in Cushing's syndrome publication-title: Neuroendocrinology doi: 10.1159/000314272 contributor: fullname: Chanson |
| SSID | ssj0014453 |
| Score | 2.5133777 |
| Snippet | Context:
Although adrenal incidentalomas (AIs) are associated with a high prevalence of cardiovascular risk (CVR) factors, it is not clear whether patients... CONTEXT:Although adrenal incidentalomas (AIs) are associated with a high prevalence of cardiovascular risk (CVR) factors, it is not clear whether patients with... Although adrenal incidentalomas (AIs) are associated with a high prevalence of cardiovascular risk (CVR) factors, it is not clear whether patients with... CONTEXTAlthough adrenal incidentalomas (AIs) are associated with a high prevalence of cardiovascular risk (CVR) factors, it is not clear whether patients with... |
| SourceID | proquest crossref pubmed pascalfrancis wolterskluwer endocrinepress |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 2754 |
| SubjectTerms | Adrenal Gland Neoplasms - blood Adrenal Gland Neoplasms - epidemiology Adrenal Gland Neoplasms - secretion Biological and medical sciences Cardiovascular Diseases - blood Cardiovascular Diseases - diagnostic imaging Cardiovascular Diseases - epidemiology Carotid Intima-Media Thickness Case-Control Studies Endocrinopathies Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Glucose Tolerance Test Hemodynamics Humans Hydrocortisone - blood Hydrocortisone - secretion Insulin Resistance Male Medical sciences Middle Aged Risk Factors Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology |
| Title | Patients With Apparently Nonfunctioning Adrenal Incidentalomas May Be at Increased Cardiovascular Risk Due to Excessive Cortisol Secretion |
| URI | http://dx.doi.org/10.1210/jc.2013-4064 http://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00004678-201408000-00021 https://www.ncbi.nlm.nih.gov/pubmed/24712565 https://search.proquest.com/docview/1552367616 |
| Volume | 99 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLa6TUI8gLiOcpmMBE8lUp3aqfs4oNPQxkCim_oW2bEjbWubaUkF-wv8as6J7aQRII0HXqLKSh0l35dzy7kQ8maY5JipYyLFxDjio0xEwBsbKWEULAkrDIYGDr-NT-by45RPe70w_qZd-69IwxpgjZWz_4B2sykswG_AHI6AOhxvhftX1yg1VK1dYYb5qlrcDMDPRyUWArAKS7jrjhsZzhXFIM5SlYOluhlg-gVODkCDsgSDNOvmrNbZ6GZdz9ywP7DMALOPwIutzuHWBiUaog3cFy0bN5pUNPWYdmUKkFurthPU0lbAy0XobFhHKMx1AVe-dO0QPhU4Zqlsw71HalGVri7NV9y0Adoj7Dmu2uj_eVG2tRdYp1Ssa-lY4RhxHzH2MRDGmww8UGFObk-4iMbMpfoGwe4mL3kCy00pPXaNq73Gj71C-E2bgDuM2gQ7XbIReNoJb7VmyBQ4-ZIenB4fp7PpfLZFdmKQdyBud_bfz8_Oms9ZnIuRr7rAkqnNHTv20L3w1F0WNCbqArZqkbshK3_yguCc7wUmVpSXdV3FhnU0e0Due7eG7js-PiQ9u3pE7nz2iRuPyc9AS4q0pC0taZeW1NOSdmlJgZZUW6oq2tCSdmlJkZYUaEmrgja0pIGWtKHlE3J6MJ19OIz8GJAo41yyKDe5jpWWueVaslHOLZjEXEkwfOOc5RMeG22lMCKxMsmMZplgSmZjqXEFtNZTsg33Yp8RannCmMZic615pqRMNBsmQyW15dlQyz55G8BIr1y3lxS9ZAAtvchSBC1F0PrkXRep1L9C5V9O3-vg2OwdywlowGTSJ68DsCmId_xmp1a2WMN2QmCPxYQlfbLrEG__DYYleCyiT6IOBVJXQp3W_j8YoxG-MugZ1j0kYvb8Fld7Qe62L9pLsl1dr-0rslWa9Z4n9y_nAOhF |
| link.rule.ids | 315,782,786,27933,27934 |
| linkProvider | Oxford University Press |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Patients+with+apparently+nonfunctioning+adrenal+incidentalomas+may+be+at+increased+cardiovascular+risk+due+to+excessive+cortisol+secretion&rft.jtitle=The+journal+of+clinical+endocrinology+and+metabolism&rft.au=Androulakis%2C+Ioannis+I&rft.au=Kaltsas%2C+Gregory+A&rft.au=Kollias%2C+Georgios+E&rft.au=Markou%2C+Athina+C&rft.date=2014-08-01&rft.eissn=1945-7197&rft.volume=99&rft.issue=8&rft.spage=2754&rft.epage=2762&rft_id=info:doi/10.1210%2Fjc.2013-4064&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-972X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-972X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-972X&client=summon |