Metastatic organotropism: a brief overview

Organotropism has been known since 1889, yet this vital component of metastasis has predominantly stayed elusive. This mini-review gives an overview of the current understanding of the underlying mechanisms of organotropism and metastases development by focusing on the formation of the pre-metastati...

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Bibliographic Details
Published in:	Frontiers in oncology Vol. 14; p. 1358786
Main Authors:	Carrolo, Margarida, Miranda, João A I, Vilhais, Guilherme, Quintela, António, Sousa, Mário Fontes E, Costa, Diogo Alpuim, Pinto, Francisco R
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 2024
Subjects:	brain metastasis immune response to metastasis metastasis Oncology organotropism pre-metastatic niche immune response to metastasis pre-metastatic niche brain metastasis metastasis organotropism
Online Access:	Get full text
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Summary:	Organotropism has been known since 1889, yet this vital component of metastasis has predominantly stayed elusive. This mini-review gives an overview of the current understanding of the underlying mechanisms of organotropism and metastases development by focusing on the formation of the pre-metastatic niche, immune defenses against metastases, and genomic alterations associated with organotropism. The particular case of brain metastases is also addressed, as well as the impact of organotropism in cancer therapy. The limited comprehension of the factors behind organotropism underscores the necessity for efficient strategies and treatments to manage metastases.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Edited by: Tao Liu, University of New South Wales, Australia Darshan Badal, University of Missouri, United States These authors have contributed equally to this work Reviewed by: Tabish H. Khan, Washington University in St. Louis, United States
ISSN:	2234-943X 2234-943X
DOI:	10.3389/fonc.2024.1358786