The effect of fibrin glue in preventing staple-line leak after sleeve gastrectomy. An experimental study in rats
Abstract Purpose To evaluate the effect of fibrin glue on staple-line leak after sleeve gastrectomy. Methods Fourteen adult wistar rats 300 gr were randomized into two groups: Control group (n=7) and study group (n=7). All the rats underwent sleeve gastrectomy using lineer stapler. In the study grou...
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| Published in: | Acta cirúrgica brasileira Vol. 34; no. 8 |
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
01-01-2019
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| Abstract | Abstract Purpose To evaluate the effect of fibrin glue on staple-line leak after sleeve gastrectomy. Methods Fourteen adult wistar rats 300 gr were randomized into two groups: Control group (n=7) and study group (n=7). All the rats underwent sleeve gastrectomy using lineer stapler. In the study group, fibrin glue was used to reinforce the staple-line. The rats were sacrificed 7 days after surgery. The stomach was resected, submerged in saline and exposed to excess pressure to obtain a burst pressure value. The gastric staple line was evaluated histopathologically according to the Ehrlich Hunt scale. The results of the two groups were compared. Results The mean Ehrlich-Hunt scores for inflammation, fibroblastic activity and neo-angiogenesis were similar between the groups (p>0.05). Collagen deposition was significantly higher in study group (3.42±0.53) when compared with control group (2.57±0.78) (p=0.035). The mean burst pressure was 137.8±8.5 mmHg for control group and 135.0±8.1 mmHg for study group (p=0.536). Conclusion Reinforcement of the staple-line with fibrin glue has no effect on the burst pressure after sleeve gastrectomy. More studies are needed to evaluate the precautions against leak after sleeve gastrectomy. |
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| AbstractList | Abstract Purpose To evaluate the effect of fibrin glue on staple-line leak after sleeve gastrectomy. Methods Fourteen adult wistar rats 300 gr were randomized into two groups: Control group (n=7) and study group (n=7). All the rats underwent sleeve gastrectomy using lineer stapler. In the study group, fibrin glue was used to reinforce the staple-line. The rats were sacrificed 7 days after surgery. The stomach was resected, submerged in saline and exposed to excess pressure to obtain a burst pressure value. The gastric staple line was evaluated histopathologically according to the Ehrlich Hunt scale. The results of the two groups were compared. Results The mean Ehrlich-Hunt scores for inflammation, fibroblastic activity and neo-angiogenesis were similar between the groups (p>0.05). Collagen deposition was significantly higher in study group (3.42±0.53) when compared with control group (2.57±0.78) (p=0.035). The mean burst pressure was 137.8±8.5 mmHg for control group and 135.0±8.1 mmHg for study group (p=0.536). Conclusion Reinforcement of the staple-line with fibrin glue has no effect on the burst pressure after sleeve gastrectomy. More studies are needed to evaluate the precautions against leak after sleeve gastrectomy. |
| Author | Ozdenkaya, Yasar Olmuscelik, Oktay Saka, Burcu Arslan, Naciye Cigdem Basim, Pelin |
| Author_xml | – sequence: 1 givenname: Yasar orcidid: 0000-0003-0428-2511 surname: Ozdenkaya fullname: Ozdenkaya, Yasar organization: Medipol University Medical Faculty, Turkey – sequence: 2 givenname: Oktay orcidid: 0000-0002-9815-1848 surname: Olmuscelik fullname: Olmuscelik, Oktay organization: Medipol University Medical Faculty,, Turkey – sequence: 3 givenname: Pelin orcidid: 0000-0002-9452-9276 surname: Basim fullname: Basim, Pelin organization: Medipol University Medical Faculty, Turkey – sequence: 4 givenname: Burcu orcidid: 0000-0001-6830-7701 surname: Saka fullname: Saka, Burcu organization: Medipol University Medical Faculty, Turkey – sequence: 5 givenname: Naciye Cigdem orcidid: 0000-0002-2282-7207 surname: Arslan fullname: Arslan, Naciye Cigdem organization: Medipol University Medical Faculty, Turkey |
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| Cites_doi | 10.1007/s11695-014-1257-3 10.1016/j.soard.2014.01.016 10.4274/balkanmedj.2017.0484 10.1016/0002-9610(92)90255-P 10.1007/s00464-016-5215-0 10.1016/j.jss.2012.12.043 10.1097/SLA.0b013e31826cc714 10.1007/s11695-013-1040-x 10.1381/0960892042583824 10.1381/096089203321136575 10.1017/S0022215100119486 10.1155/2014/203943 10.11138/gchir/2017.38.1.050 10.1381/0960892042583888 10.4293/JSLS.2015.00040 10.1089/lap.2014.0408 10.1177/000313481808400958 10.1007/s11695-015-1580-3 10.1007/s11695-008-9668-7 10.1007/s00464-008-9885-0 10.1016/j.ijsu.2015.12.007 10.1016/j.soard.2015.05.003 10.1016/1010-7940(93)90184-D 10.1007/s13304-014-0257-0 10.1007/s11695-018-3525-0 10.1111/obr.12647 10.1007/s11605-015-2999-5 10.1007/s00464-011-2085-3 |
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