Layered immunity of the developing thymus
In this issue of Blood , Elsaid et al reinforce the temporal and spatial complexity of immune layering during embryogenesis by intricately dissecting 2 distinct waves of early thymic progenitors (ETPs) that differentially contribute to normal thymic organogenesis and homeostasis. 1 The concept of “l...
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| Published in: | Blood Vol. 137; no. 8; pp. 1003 - 1004 |
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| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Elsevier Inc
25-02-2021
American Society of Hematology |
| Series: | Hematopoiesis and Stem Cells |
| Online Access: | Get full text |
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| Summary: | In this issue of
Blood
,
Elsaid et al
reinforce the temporal and spatial complexity of immune layering during embryogenesis by intricately dissecting 2 distinct waves of early thymic progenitors (ETPs) that differentially contribute to normal thymic organogenesis and homeostasis.
1
The concept of “layered immunity,” in the form of waves of different immune cells derived from developmentally distinct progenitor populations, was initially described for innate-like lymphocytes, including B1-B cells and γ-δ T cells.
2
,
3
Cellular compartments generated by layered immunity now extend beyond subsets of innate-like B and T cells to include tissue-resident macrophages,
4
innate lymphoid cells (ILC),
5
and mast cells.
6 |
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| Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Commentary-1 |
| ISSN: | 0006-4971 1528-0020 |
| DOI: | 10.1182/blood.2020009207 |