Matrix metalloproteinase-9 and tissue inhibitors of metalloproteinases 1 in influenza-associated encephalopathy

• Published in: The Pediatric infectious disease journal Vol. 26; no. 6; pp. 542 - 544
• Main Authors: ICHIYAMA, Takashi, MORISHIMA, Tsuneo, KAJIMOTO, Madoka, MATSUSHIGE, Takeshi, MATSUBARA, Tomoyo, FURUKAWA, Susumu
• Format: Journal Article
• Language: English
• Published: Baltimore, MD Lippincott 01-06-2007; Philadelphia, PA; Hagerstown, MD
• Subjects: Adolescent; Biological and medical sciences; Blood-Brain Barrier - physiology; Child; Child, Preschool; Encephalitis, Viral - enzymology; Encephalitis, Viral - pathology; Female; Human viral diseases; Humans; Infant; Infectious diseases; Influenza, Human - complications; Influenza, Human - enzymology; Male; Matrix Metalloproteinase 9 - blood; Medical sciences; Seizures, Febrile; Tissue Inhibitor of Metalloproteinase-1 - blood; Viral diseases; Viral diseases of the respiratory system and ent viral diseases; Human respiratory syncytial virus; Pediatrics; Epstein Barr virus; Febrile convulsion; Blood brain barrier; Paramyxoviridae; Respiratory tract; 2007; Encephalopathy; TIMP-1 Accepted for publication January 19; Metalloproteinase; Epstein-Barr virus; Pneumovirus; Neurological disorder; Gammaherpesvirinae; Nervous system diseases; Pneumovirinae; Respiratory disease; Herpesviridae; influenza-associated encephalopathy; Cerebral disorder; Infection; Virus; Mononegavirales; Viral disease; Influenza; Central nervous system disease; MMP-9; respiratory syncytial virus
• ISSN: 0891-3668; 1532-0987
• DOI: 10.1097/inf.0b013e31803994a0

Matrix metalloproteinase-9 (MMP-9) and tissue inhibitors of metalloproteinases 1 (TIMP-1) play important roles in the function of the blood-brain barrier. Serum MMP-9 and TIMP-1 concentrations were determined in influenza virus infection with or without neurologic complications. Our results suggest that an imbalance between MMP-9 and TIMP-1 damages the blood-brain barrier and promotes febrile seizure or encephalopathy in influenza virus infection.