Basic Drug-Enterosoluble Polymer Coevaporates: Development of Oral Controlled Release Systems

Precipitation of basic drugs within oral prolonged release systems, at the higher pH values of the intestine, would affect drug release. Coevaporates of a model basic drug verapamil HCl, in single or mixed polymer systems, containing Eudragit L100 (L100) and ethyl cellulose or Eudragit RS100, were p...

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Bibliographic Details
Published in:	Drug development and industrial pharmacy Vol. 30; no. 8; pp. 847 - 857
Main Authors:	Govindarajan, Ramprakash, Nagarsenker, Mangal S.
Format:	Journal Article
Language:	English
Published:	Colchester Informa UK Ltd 01-01-2004 Taylor & Francis
Subjects:	Administration, Oral Basic drug Biological and medical sciences Cellulose - analogs & derivatives Cellulose - chemistry Cellulose - pharmacokinetics Chemistry, Pharmaceutical - methods Coevaporates Crystallization Delayed-Action Preparations - chemistry Delayed-Action Preparations - pharmacokinetics Diffusion - drug effects Eudragit L100 Excipients - chemistry Excipients - pharmacokinetics Gastric Juice - drug effects Gastric Juice - physiology General pharmacology Hydrogen-Ion Concentration Intestinal Secretions - drug effects Intestinal Secretions - physiology Medical sciences Oral controlled release Particle Size Pellets Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Plasticizers - chemistry Plasticizers - pharmacokinetics Polymers - chemistry Polymers - pharmacokinetics Polymethacrylic Acids - chemistry Polymethacrylic Acids - pharmacokinetics Tablets Technology, Pharmaceutical - methods Verapamil - pharmacokinetics Verapamil HCl Volatilization Dosage form Pharmaceutical technology Controlled release form Control release polymer Base Oral administration
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