Is There an Immunohistochemical PD-L1 Cut-Off Point That Serves as a Prognostic Indicator for Large B-Cell Lymphomas?

• Published in: Diagnostics (Basel) Vol. 14; no. 11; p. 1167
• Main Authors: Cin, Selcuk, Aki, Suat Hilal, Elverdi, Tugrul, Ozmen, Deniz, Salihoglu, Ayse
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 31-05-2024; MDPI
• Subjects: Age; Antibodies; Biological products; Bone marrow; cut-off; Cytokines; Expected values; FDA approval; Gender; Health aspects; Hematology; Immune system; immunohistochemical; Immunotherapy; large B-cell lymphoma; Lymphoma; Medical prognosis; Medical research; Medicine, Experimental; Non-Hodgkin's lymphomas; Patients; pd-l1; prognosis; Statistical analysis; Viral antibodies; Ann Arbor Michigan; United States > US; cut-off; large B-cell lymphoma; prognosis; pd-l1; immunotherapy; immunohistochemical
• ISSN: 2075-4418; 2075-4418
• DOI: 10.3390/diagnostics14111167

The aim of this study is to investigate whether there is a cut-off value for PD-L1 expression in large B-cell lymphomas that predicts prognosis, and to clarify the relationship between PD-L1 expression and histopathological as well as clinical parameters. The study included a total of 130 patients who were diagnosed with large B-cell lymphoma at Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Pathology Department. Biopsy samples were assessed using the PD-L1 immunohistochemical antibody (Dako, 22C3 clone). The patients had a mean age of 54 ± 17 years, with a median age of 56 years. No statistically significant difference was observed between the groups in terms of survival when the 30% cut-off value was used. However, a noteworthy discrepancy in survival became apparent when the cut-off point was established at 70%. Among the diffuse large B-cell lymphoma-not otherwise specified (DLBCL-NOS) category, the activated B-cell-like (ABC-like) phenotype showed higher PD-L1 expression compared to the germinal center B-cell-like (GCB-like) phenotype. Immunohistochemical PD-L1 expression emerged as a prognostic factor, particularly significant in the ABC-like phenotype.