Inhibition of the epigenetic suppressor EZH2 primes osteogenic differentiation mediated by BMP2

Bone-stimulatory therapeutics include bone morphogenetic proteins (e.g. BMP2), parathyroid hormone, and antibody-based suppression of WNT antagonists. Inhibition of the epigenetic enzyme enhancer of zeste homolog 2 (EZH2) is both bone anabolic and osteoprotective. EZH2 inhibition stimulates key comp...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 295; no. 23; pp. 7877 - 7893
Main Authors:	Dudakovic, Amel, Samsonraj, Rebekah M., Paradise, Christopher R., Galeano-Garces, Catalina, Mol, Merel O., Galeano-Garces, Daniela, Zan, Pengfei, Galvan, M. Lizeth, Hevesi, Mario, Pichurin, Oksana, Thaler, Roman, Begun, Dana L., Kloen, Peter, Karperien, Marcel, Larson, A. Noelle, Westendorf, Jennifer J., Cool, Simon M., van Wijnen, Andre J.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 05-06-2020 American Society for Biochemistry and Molecular Biology
Subjects:	3T3 Cells Animals BMP2 bone development bone morphogenetic protein (BMP) Bone Morphogenetic Protein 2 - administration & dosage Bone Morphogenetic Protein 2 - metabolism Cell Differentiation - drug effects Cells, Cultured chromatin regulation enhancer of zeste homolog Enhancer of Zeste Homolog 2 Protein - antagonists & inhibitors Enhancer of Zeste Homolog 2 Protein - metabolism epigenetics Ezh2 Gene Regulation histone methylation Humans Indoles - administration & dosage Indoles - pharmacology mesenchymal stem cells (MSCs) methyltransferase Mice osteoblast Osteoblasts - drug effects osteogenesis Osteogenesis - drug effects Pyridones - administration & dosage Pyridones - pharmacology histone methylation BMP2 methyltransferase mesenchymal stem cells (MSCs) chromatin regulation enhancer of zeste homolog bone development bone morphogenetic protein (BMP) osteoblast osteogenesis epigenetics Ezh2
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