Chalcone T4 Inhibits RANKL-Induced Osteoclastogenesis and Stimulates Osteogenesis In Vitro

Chalcones are phenolic compounds produced during the biosynthesis of flavonoids that have numerous biological activities, including anti-inflammatory, antioxidant and anticancer. In this in vitro study, we investigate a newly synthesized chalcone (Chalcone T4) in the context of bone turnover, specif...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 24; no. 8; p. 7624
Main Authors:	de Matos, Iolanda Augusta Fernandes, Fernandes, Natalie Aparecida Rodrigues, Cirelli, Giovani, de Godoi, Mariely Araújo, de Assis, Letícia Ribeiro, Regasini, Luis Octávio, Rossa Junior, Carlos, Guimarães-Stabili, Morgana Rodrigues
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 21-04-2023 MDPI
Subjects:	Animals B cells Bone Resorption - metabolism Cell Differentiation chalcone Chalcone - metabolism Chalcone - pharmacology Chalcones - therapeutic use Core Binding Factor Alpha 1 Subunit - metabolism intracellular signaling Isoflavones Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Mice NF-kappa B - metabolism NFATC Transcription Factors - genetics NFATC Transcription Factors - metabolism osteoclastogenesis Osteoclasts - metabolism Osteogenesis Physiological aspects Proto-Oncogene Proteins c-akt - metabolism RANK Ligand - metabolism chalcone intracellular signaling osteogenesis osteoclastogenesis
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