Within-Host Adaptation Mediated by Intergenic Evolution in Pseudomonas aeruginosa

Bacterial pathogens evolve during the course of infection as they adapt to the selective pressures that confront them inside the host. Identification of adaptive mutations and their contributions to pathogen fitness remains a central challenge. Although mutations can either target intergenic or codi...

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Bibliographic Details
Published in:	Genome biology and evolution Vol. 11; no. 5; pp. 1385 - 1397
Main Authors:	Khademi, S M Hossein, Sazinas, Pavelas, Jelsbak, Lars
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 01-05-2019
Subjects:	Adaptation, Biological antibiotic resistance bacterial adaptation Basic Medicine Biologi Biological Sciences cis-regulatory elements Data Mining DNA, Intergenic Drug Resistance, Bacterial - genetics Evolution, Molecular gene expression Gene Expression Regulation, Bacterial Genes, Essential Genetics Genetik Host-Pathogen Interactions - genetics intergenic evolution Medical and Health Sciences Medical Genetics Medicin och hälsovetenskap Medicinsk genetik Medicinska och farmaceutiska grundvetenskaper Mutation Natural Sciences Naturvetenskap Promoter Regions, Genetic Pseudomonas aeruginosa - genetics cis-regulatory elements bacterial adaptation antibiotic resistance intergenic evolution gene expression
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