Selective elimination/RNAi silencing of FMRF-related peptides and their receptors decreases the locomotor activity in Drosophila melanogaster

Highlights • RNAi knockdown of FaRP genes decreased startle-induced locomotor activity of flies. • Three Gal4 drivers were constructed with 5′ regulatory sequences of the Fmrf gene. • The new drivers express Gal4 in partial FMRF neuronal pattern and some ectopic cells. • Cell ablation targeted by th...

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Published in:	General and comparative endocrinology Vol. 191; pp. 137 - 145
Main Authors:	Kiss, Brigitta, Szlanka, Tamás, Zvara, Ágnes, Žurovec, Michal, Sery, Michal, Kakaš, Štefan, Ramasz, Beáta, Hegedűs, Zoltán, Lukacsovich, Tamás, Puskás, László, Fónagy, Adrien, Kiss, István
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 15-09-2013
Subjects:	Animals Drosophila melanogaster Endocrinology & Metabolism Female FMRF-related peptides FMRFamide - metabolism G protein-coupled receptors Insect Hormones - metabolism Locomotor activity Male Microscopy, Confocal Motor Activity - physiology Neuropeptides - metabolism RNA Interference RNAi-silencing UAS-reaper ablation FMRF-related peptides G protein-coupled receptors UAS-reaper ablation Drosophila melanogaster RNAi-silencing Locomotor activity
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Summary:	Highlights • RNAi knockdown of FaRP genes decreased startle-induced locomotor activity of flies. • Three Gal4 drivers were constructed with 5′ regulatory sequences of the Fmrf gene. • The new drivers express Gal4 in partial FMRF neuronal pattern and some ectopic cells. • Cell ablation targeted by the new drivers can also influence adult locomotor activity.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0016-6480 1095-6840
DOI:	10.1016/j.ygcen.2013.05.023