Treatment of Localized and Locally Advanced, High-Risk Prostate Cancer: A Report From the First Prostate Cancer Consensus Conference for Developing Countries

• Published in: JCO global oncology Vol. 7; no. 7; pp. 530 - 537
• Main Authors: Khauli, Raja, Ferrigno, Robson, Guimarães, Gustavo, Bulbulan, Muhammad, Uson Junior, Pedro Luiz Serrano, Salvajoli, Bernardo, Palhares, Daniel Moore Freitas, Racy, Douglas, Gil, Erlon, de Arruda, Fernando Freire, Lemos, Gustavo Caserta, Carvalhal, Gustavo Franco, de Carvalho, Icaro Thiago, Martins, Igor Austin Fernandes, Gimpel, Ivan Frederico Pinto, Salvajoli, João Victor, Chambo, José Luis, Pontes, Jr, José, Filho, Leopoldo Alves Ribeiro, Nogueira, Lucas, Freitas, Marcelo Roberto Pereira, Wroclawski, Marcelo, Arap, Marco Antonio, Sadi, Marcus Vinicius, Coelho, Rafael, Gadia, Rafael, Roja, Rodrigo Antonio Ledezma, Hanriot, Rodrigo de Moraes, Baroni, Ronaldo, Zequi, Stenio, Nahas, William Carlos, Alfer, Jr, Wladimir, Maluf, Fernando Cotait
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health 01-04-2021; American Society of Clinical Oncology
• Subjects: Consensus; Developing Countries; Humans; Male; Prostatic Neoplasms - diagnosis; Prostatic Neoplasms - therapy; SPECIAL ARTICLES
• DOI: 10.1200/GO.20.00421
• EISSN: 2687-8941

To generate and present survey results on important issues relevant to treatment and follow-up of localized and locally advanced, high-risk prostate cancer (PCa) focusing on developing countries.
A panel of 99 PCa experts developed more than 300 survey questions of which 67 questions concern the main areas of interest of this article: treatment and follow-up of localized and locally advanced, high-risk PCa in developing countries. A larger panel of 99 international multidisciplinary cancer experts voted on these questions to create the recommendations for treatment and follow-up of localized and locally advanced, high-risk PCa in areas of limited resources discussed in this article.
The panel voted publicly but anonymously on the predefined questions. Each question was deemed consensus if 75% or more of the full panel had selected a particular answer. These answers are based on panelist opinion and not on a literature review or meta-analysis. For questions that refer to an area of limited resources, the recommendations considered cost-effectiveness as well as the possible therapies with easier and greater access. Each question had five to seven relevant answers including two nonanswers. Results were tabulated in real time.
The voting results and recommendations presented in this article can guide physicians managing localized and locally advanced, high-risk PCa in areas of limited resources. Individual clinical decision making should be supported by available data; however, as guidelines for treatment of localized and locally advanced, high-risk PCa in developing countries have not been defined, this article will serve as a point of reference when confronted with this disease.