Genome-wide expression profiling of the response to ciclopirox olamine in Candida albicans

Objectives: The aim of this study was to identify changes in the gene expression profile of Candida albicans upon exposure to the hydroxypyridone anti-infective agent ciclopirox olamine in an effort to better understand its mechanism of action. Methods: C. albicans SC5314 was exposed to either mediu...

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Bibliographic Details
Published in:	Journal of antimicrobial chemotherapy Vol. 55; no. 5; pp. 655 - 662
Main Authors:	Lee, Robin E. B., Liu, Teresa T., Barker, Katherine S., Lee, Richard E., Rogers, P. David
Format:	Journal Article
Language:	English
Published:	Oxford Oxford University Press 01-05-2005 Oxford Publishing Limited (England)
Subjects:	Antibiotics. Antiinfectious agents. Antiparasitic agents antifungal activity Antifungal Agents - pharmacology Biological and medical sciences C. albicans Candida albicans Candida albicans - drug effects Candida albicans - genetics Candida albicans - growth & development Candida albicans - metabolism efflux pumps Fungal Proteins - genetics Fungal Proteins - metabolism Gene Expression Profiling Gene Expression Regulation, Fungal gene regulation Genome, Fungal Humans Medical sciences microarrays Microbial Sensitivity Tests Mutation Oligonucleotide Array Sequence Analysis Pharmacology. Drug treatments Pyridones - pharmacology Reverse Transcriptase Polymerase Chain Reaction Candida albicans Yeast Ciclopirox antifungal activity microarrays Fungi Antifungal agent Regulation(control) Gene C. albicans gene regulation Olamine Fungi Imperfecti Genome efflux pumps Thallophyta
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