Synthesis and antimicrobial activity of some new thiazolyl thiazolidine-2,4-dione derivatives

• Published in: Bioorganic & medicinal chemistry Vol. 15; no. 18; pp. 6012 - 6017
• Main Authors: Bozdağ-Dündar, Oya, Özgen, Özen, Menteşe, Arzu, Altanlar, Nurten, Atlı, Onur, Kendi, Engin, Ertan, Rahmiye
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 15-09-2007; Elsevier Science
• Subjects: Anti-Bacterial Agents - chemical synthesis; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antifungal agents; Antifungal Agents - chemical synthesis; Antifungal Agents - chemistry; Antifungal Agents - pharmacology; Antimicrobial activity; Biological and medical sciences; Candida albicans - drug effects; Candida albicans - growth & development; Escherichia coli - drug effects; Escherichia coli - growth & development; Medical sciences; Methicillin - pharmacology; Methicillin Resistance; Microbial Sensitivity Tests; Models, Chemical; Molecular Structure; Pharmacology. Drug treatments; Single-X-ray structure; Staphylococcus aureus - drug effects; Staphylococcus aureus - growth & development; Thiazole derivatives; Thiazolidine-2,4-diones; Thiazolidines - chemical synthesis; Thiazolidines - chemistry; Thiazolidines - pharmacology; Antimicrobial activity; Single-X-ray structure; Thiazole derivatives; Thiazolidine-2,4-diones; Candida albicans; Escherichia coli; Antimicrobial agent; Meticillin; Fungi; Antifungal agent; Structure activity relation; Chlorine Organic compounds; Bacteria; Micrococcales; Micrococcaceae; Fungi Imperfecti; Chemical synthesis; Staphylococcus aureus; Enterobacteriaceae; In vitro; Resistance; Microorganism; Antibacterial agent; Crystalline structure; Thiazolidine derivatives
• ISSN: 0968-0896; 1464-3391
• DOI: 10.1016/j.bmc.2007.06.049

A new series of thiazolyl thiazolidine-2,4-diones were synthesized and tested for their in vitro antimicrobial activities.
In this study, a series of thiazolyl thiazolidine-2,4-dione derivatives (
Va–
f and
VIa–
f) were synthesized and evaluated for their antibacterial and antifungal activities against
Staphylococcus aureus (ATCC 25923), methicillin resistant
S. aureus (MRSA ATCC 43300), methicillin resistant
S. aureus (MRSA
isolate), and
Escherichia coli (ATCC 23556) and
C. albicans (ATCC10145). All the compounds were found active against used microorganisms.