Pilocarpine-induced epilepsy alters the expression and daily variation of the nuclear receptor RORα in the hippocampus of rats

Abstract It is widely known that there is an increase in the inflammatory responses and oxidative stress in temporal lobe epilepsy (TLE). Further, the seizures follow a circadian rhythmicity. Retinoic acid receptor-related orphan receptor alpha (RORα) is related to anti-inflammatory and antioxidant...

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Bibliographic Details
Published in:	Epilepsy & behavior Vol. 55; pp. 38 - 46
Main Authors:	Rocha, Anna Karynna Alves de Alencar, de Lima, Eliangela, Amaral, Fernanda Gaspar do, Peres, Rafael, Cipolla-Neto, José, Amado, Débora
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-02-2016
Subjects:	Animals Chronic Disease Circadian Rhythm - genetics Epilepsy Epilepsy - chemically induced Epilepsy - metabolism Gene Expression Regulation - drug effects Hippocampus - drug effects Hippocampus - metabolism Male Muscarinic Agonists Neurology Nuclear Receptor Subfamily 1, Group F, Member 1 - biosynthesis Nuclear Receptor Subfamily 1, Group F, Member 1 - genetics Pilocarpine Rats Rats, Wistar RNA, Messenger - biosynthesis RNA, Messenger - genetics RORα receptor Status Epilepticus - chemically induced Status Epilepticus - genetics RORα receptor Epilepsy Pilocarpine
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