Assessment of Serum Apelin Levels in Girls with Anorexia Nervosa

Context: Pilot studies in rats have suggested that apelin (APE) is involved in the control of appetite and food intake. APE is secreted in the organs involved in the control of hunger and satiety: the stomach, hypothalamus, and fat tissue. Anorexia nervosa (AN) is an eating disorder that represents...

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Published in:	The journal of clinical endocrinology and metabolism Vol. 95; no. 6; pp. 2935 - 2941
Main Authors:	Ziora, Katarzyna, Oświęcimska, Joanna, Świętochowska, Elżbieta, Ziora, Dariusz, Ostrowska, Zofia, Stojewska, Małgorzata, Klimacka-Nawrot, Ewa, Dyduch, Antoni, Błońska-Fajfrowska, Barbara
Format:	Journal Article
Language:	English
Published:	Bethesda, MD Endocrine Society 01-06-2010 Copyright by The Endocrine Society
Subjects:	Adipose Tissue - physiology Adolescent Anorexia Nervosa - blood Apelin Biological and medical sciences Biomarkers - blood Body Composition - physiology Body Height - physiology Body Mass Index Body Weight - physiology Child Endocrinopathies Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Humans Immunoenzyme Techniques Intercellular Signaling Peptides and Proteins - blood Medical sciences Obesity - blood Poland Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology Human Obesity Nutrition Nutrition disorder Clinical biology Female Metabolic diseases Anorexia nervosa Eating disorder Child Endocrinology Nutritional status
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Abstract	Context: Pilot studies in rats have suggested that apelin (APE) is involved in the control of appetite and food intake. APE is secreted in the organs involved in the control of hunger and satiety: the stomach, hypothalamus, and fat tissue. Anorexia nervosa (AN) is an eating disorder that represents a good biological model of chronic fat tissue atrophy in humans. To date, there are no reports of APE expression in the fat tissue and its circulating concentrations in patients with AN. Objective: Our objective was to assess serum APE concentrations in girls with AN. Design, Participants, and Setting: APE-36 and APE-12 serum concentrations were evaluated in 87 Polish girls with restrictive AN, in 61 healthy (H) controls, 17 girls with no otherwise specified eating disorders (NOS), and 30 girls with simple obesity (OB). Results: Mean serum APE-36 and APE-12 concentrations in patients with AN and NOS were significantly lower than in the H and OB groups. However, no differences between AN, H, and NOS groups were observed when APE concentrations were calculated per body mass index (BMI). In participants with normal BMI, serum APE-36 (r = 0.35) and APE-12 (r = 0.37) concentrations correlated positively with BMI. Conclusions: We conclude that compared with H controls, serum APE-36 and APE-12 concentrations decreased as a result of fat tissue depletion in patients with AN. Conversely, obese adolescents had elevated APE-36 and APE-12 due to excessive fat mass as well as increased APE production in adipose tissue. In patients with anorexia nervosa compared with healthy controls, serum APE-36 and APE-12 concentrations are decreased as a result from fat tissue depletion.
AbstractList	Context: Pilot studies in rats have suggested that apelin (APE) is involved in the control of appetite and food intake. APE is secreted in the organs involved in the control of hunger and satiety: the stomach, hypothalamus, and fat tissue. Anorexia nervosa (AN) is an eating disorder that represents a good biological model of chronic fat tissue atrophy in humans. To date, there are no reports of APE expression in the fat tissue and its circulating concentrations in patients with AN. Objective: Our objective was to assess serum APE concentrations in girls with AN. Design, Participants, and Setting: APE-36 and APE-12 serum concentrations were evaluated in 87 Polish girls with restrictive AN, in 61 healthy (H) controls, 17 girls with no otherwise specified eating disorders (NOS), and 30 girls with simple obesity (OB). Results: Mean serum APE-36 and APE-12 concentrations in patients with AN and NOS were significantly lower than in the H and OB groups. However, no differences between AN, H, and NOS groups were observed when APE concentrations were calculated per body mass index (BMI). In participants with normal BMI, serum APE-36 (r = 0.35) and APE-12 (r = 0.37) concentrations correlated positively with BMI. Conclusions: We conclude that compared with H controls, serum APE-36 and APE-12 concentrations decreased as a result of fat tissue depletion in patients with AN. Conversely, obese adolescents had elevated APE-36 and APE-12 due to excessive fat mass as well as increased APE production in adipose tissue. Context: Pilot studies in rats have suggested that apelin (APE) is involved in the control of appetite and food intake. APE is secreted in the organs involved in the control of hunger and satiety: the stomach, hypothalamus, and fat tissue. Anorexia nervosa (AN) is an eating disorder that represents a good biological model of chronic fat tissue atrophy in humans. To date, there are no reports of APE expression in the fat tissue and its circulating concentrations in patients with AN. Objective: Our objective was to assess serum APE concentrations in girls with AN. Design, Participants, and Setting: APE-36 and APE-12 serum concentrations were evaluated in 87 Polish girls with restrictive AN, in 61 healthy (H) controls, 17 girls with no otherwise specified eating disorders (NOS), and 30 girls with simple obesity (OB). Results: Mean serum APE-36 and APE-12 concentrations in patients with AN and NOS were significantly lower than in the H and OB groups. However, no differences between AN, H, and NOS groups were observed when APE concentrations were calculated per body mass index (BMI). In participants with normal BMI, serum APE-36 (r = 0.35) and APE-12 (r = 0.37) concentrations correlated positively with BMI. Conclusions: We conclude that compared with H controls, serum APE-36 and APE-12 concentrations decreased as a result of fat tissue depletion in patients with AN. Conversely, obese adolescents had elevated APE-36 and APE-12 due to excessive fat mass as well as increased APE production in adipose tissue. In patients with anorexia nervosa compared with healthy controls, serum APE-36 and APE-12 concentrations are decreased as a result from fat tissue depletion. CONTEXT:Pilot studies in rats have suggested that apelin (APE) is involved in the control of appetite and food intake. APE is secreted in the organs involved in the control of hunger and satietythe stomach, hypothalamus, and fat tissue. Anorexia nervosa (AN) is an eating disorder that represents a good biological model of chronic fat tissue atrophy in humans. To date, there are no reports of APE expression in the fat tissue and its circulating concentrations in patients with AN. OBJECTIVE:Our objective was to assess serum APE concentrations in girls with AN. DESIGN, PARTICIPANTS, AND SETTING:APE-36 and APE-12 serum concentrations were evaluated in 87 Polish girls with restrictive AN, in 61 healthy (H) controls, 17 girls with no otherwise specified eating disorders (NOS), and 30 girls with simple obesity (OB). RESULTS:Mean serum APE-36 and APE-12 concentrations in patients with AN and NOS were significantly lower than in the H and OB groups. However, no differences between AN, H, and NOS groups were observed when APE concentrations were calculated per body mass index (BMI). In participants with normal BMI, serum APE-36 (r = 0.35) and APE-12 (r = 0.37) concentrations correlated positively with BMI. CONCLUSIONS:We conclude that compared with H controls, serum APE-36 and APE-12 concentrations decreased as a result of fat tissue depletion in patients with AN. Conversely, obese adolescents had elevated APE-36 and APE-12 due to excessive fat mass as well as increased APE production in adipose tissue. Pilot studies in rats have suggested that apelin (APE) is involved in the control of appetite and food intake. APE is secreted in the organs involved in the control of hunger and satiety: the stomach, hypothalamus, and fat tissue. Anorexia nervosa (AN) is an eating disorder that represents a good biological model of chronic fat tissue atrophy in humans. To date, there are no reports of APE expression in the fat tissue and its circulating concentrations in patients with AN. Our objective was to assess serum APE concentrations in girls with AN. APE-36 and APE-12 serum concentrations were evaluated in 87 Polish girls with restrictive AN, in 61 healthy (H) controls, 17 girls with no otherwise specified eating disorders (NOS), and 30 girls with simple obesity (OB). Mean serum APE-36 and APE-12 concentrations in patients with AN and NOS were significantly lower than in the H and OB groups. However, no differences between AN, H, and NOS groups were observed when APE concentrations were calculated per body mass index (BMI). In participants with normal BMI, serum APE-36 (r = 0.35) and APE-12 (r = 0.37) concentrations correlated positively with BMI. We conclude that compared with H controls, serum APE-36 and APE-12 concentrations decreased as a result of fat tissue depletion in patients with AN. Conversely, obese adolescents had elevated APE-36 and APE-12 due to excessive fat mass as well as increased APE production in adipose tissue. CONTEXTPilot studies in rats have suggested that apelin (APE) is involved in the control of appetite and food intake. APE is secreted in the organs involved in the control of hunger and satiety: the stomach, hypothalamus, and fat tissue. Anorexia nervosa (AN) is an eating disorder that represents a good biological model of chronic fat tissue atrophy in humans. To date, there are no reports of APE expression in the fat tissue and its circulating concentrations in patients with AN.OBJECTIVEOur objective was to assess serum APE concentrations in girls with AN.DESIGN, PARTICIPANTS, AND SETTINGAPE-36 and APE-12 serum concentrations were evaluated in 87 Polish girls with restrictive AN, in 61 healthy (H) controls, 17 girls with no otherwise specified eating disorders (NOS), and 30 girls with simple obesity (OB).RESULTSMean serum APE-36 and APE-12 concentrations in patients with AN and NOS were significantly lower than in the H and OB groups. However, no differences between AN, H, and NOS groups were observed when APE concentrations were calculated per body mass index (BMI). In participants with normal BMI, serum APE-36 (r = 0.35) and APE-12 (r = 0.37) concentrations correlated positively with BMI.CONCLUSIONSWe conclude that compared with H controls, serum APE-36 and APE-12 concentrations decreased as a result of fat tissue depletion in patients with AN. Conversely, obese adolescents had elevated APE-36 and APE-12 due to excessive fat mass as well as increased APE production in adipose tissue.
Author	Świętochowska, Elżbieta Ziora, Dariusz Dyduch, Antoni Ziora, Katarzyna Stojewska, Małgorzata Ostrowska, Zofia Klimacka-Nawrot, Ewa Oświęcimska, Joanna Błońska-Fajfrowska, Barbara
AuthorAffiliation	Department of Pediatrics in Zabrze (K.Z., J.O., M.S., A.D.), Medical University of Silesia in Katowice, 41-800 Zabrze, Poland; Department of Biochemistry in Zabrze (E.S., Z.O.), Medical University of Silesia in Katowice, 41-808 Zabrze, Poland; Department of Pneumonology and Tuberculosis in Zabrze (D.Z.), Medical University of Silesia in Katowice, 41-800 Zabrze, Poland; and Department of Basic Biomedical Science in Sosnowiec (E.K.-N., B.B.-F.), Medical University of Silesia in Katowice, 41-200 Sosnowiec, Poland
AuthorAffiliation_xml	– name: Department of Pediatrics in Zabrze (K.Z., J.O., M.S., A.D.), Medical University of Silesia in Katowice, 41-800 Zabrze, Poland; Department of Biochemistry in Zabrze (E.S., Z.O.), Medical University of Silesia in Katowice, 41-808 Zabrze, Poland; Department of Pneumonology and Tuberculosis in Zabrze (D.Z.), Medical University of Silesia in Katowice, 41-800 Zabrze, Poland; and Department of Basic Biomedical Science in Sosnowiec (E.K.-N., B.B.-F.), Medical University of Silesia in Katowice, 41-200 Sosnowiec, Poland
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Snippet	Context: Pilot studies in rats have suggested that apelin (APE) is involved in the control of appetite and food intake. APE is secreted in the organs involved... CONTEXT:Pilot studies in rats have suggested that apelin (APE) is involved in the control of appetite and food intake. APE is secreted in the organs involved... Pilot studies in rats have suggested that apelin (APE) is involved in the control of appetite and food intake. APE is secreted in the organs involved in the... CONTEXTPilot studies in rats have suggested that apelin (APE) is involved in the control of appetite and food intake. APE is secreted in the organs involved in...
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SubjectTerms	Adipose Tissue - physiology Adolescent Anorexia Nervosa - blood Apelin Biological and medical sciences Biomarkers - blood Body Composition - physiology Body Height - physiology Body Mass Index Body Weight - physiology Child Endocrinopathies Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Humans Immunoenzyme Techniques Intercellular Signaling Peptides and Proteins - blood Medical sciences Obesity - blood Poland Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology
Title	Assessment of Serum Apelin Levels in Girls with Anorexia Nervosa
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