Autonomic and Vascular Control in Prehypertensive Subjects with a Family History of Arterial Hypertension

• Published in: Arquivos brasileiros de cardiologia Vol. 110; no. 2; pp. 166 - 174
• Main Authors: Amaral, Josária Ferraz, Borsato, Diana de Medeiros Andrade, Freitas, Isabelle Magalhães Guedes, Toschi-Dias, Edgar, Martinez, Daniel Godoy, Laterza, Mateus Camaroti
• Format: Journal Article
• Language: English
• Published: Brazil Sociedade Brasileira de Cardiologia - SBC 01-02-2018; Sociedade Brasileira de Cardiologia (SBC)
• Subjects: Autonomic Nervous System; CARDIAC & CARDIOVASCULAR SYSTEMS; Endothelium, Vascular / physiopathology; Hypertension / genetic; Original; Risk Factors; Endotélio Vascular / fisiopatologia; Endothelium, Vascular / physiopathology; Hypertension / genetic; Risk Factors; Hipertensão / genética; Autonomic Nervous System; Sistema Nervoso Autonômico; Fatores de Risco
• ISSN: 0066-782X; 1678-4170; 1678-4170
• DOI: 10.5935/abc.20180006

Individuals with a family history of systemic arterial hypertension (FHSAH) and / or prehypertension have a higher risk of developing this pathology.
To evaluate the autonomic and vascular functions of prehypertensive patients with FHSAH.
Twenty-five young volunteers with FHSAH, 14 normotensive and 11 prehypertensive subjects were submitted to vascular function evaluation by forearm vascular conductance(VC) during resting and reactive hyperemia (Hokanson®) and cardiac and peripheral autonomic modulation, quantified, respectively, by spectral analysis of heart rate (ECG) and systolic blood pressure (SBP) (FinometerPRO®). The transfer function analysis was used to measure the gain and response time of baroreflex. The statistical significance adopted was p ≤ 0.05.
Pre-hypertensive individuals, in relation to normotensive individuals, have higher VC both at rest (3.48 ± 1.26 vs. 2.67 ± 0.72 units, p = 0.05) and peak reactive hyperemia (25, 02 ± 8.18 vs. 18.66 ± 6.07 units, p = 0.04). The indices of cardiac autonomic modulation were similar between the groups. However, in the peripheral autonomic modulation, greater variability was observed in prehypertensive patients compared to normotensive individuals (9.4 [4.9-12.7] vs. 18.3 [14.8-26.7] mmHg2; p < 0.01) and higher spectral components of very low (6.9 [2.0-11.1] vs. 13.5 [10.7-22.4] mmHg2, p = 0.01) and low frequencies (1.7 [1.0-3.0] vs. 3.0 [2.0-4.0] mmHg2, p = 0.04) of SBP. Additionally, we observed a lower gain of baroreflex control in prehypertensive patients compared to normotensive patients (12.16 ± 4.18 vs. 18.23 ± 7.11 ms/mmHg, p = 0.03), but similar delay time (-1.55 ± 0.66 vs. -1.58 ± 0.72 s, p = 0.90).
Prehypertensive patients with FHSAH have autonomic dysfunction and increased vascular conductance when compared to normotensive patients with the same risk factor.