159C>T CD14 genotype—Functional effects on innate immune responses in term neonates

Summary Given the susceptibility of newborns to infection and the potential harm of overwhelming proinflammatory immune responses, the impact of genetic variation in innate immune molecules is of increasing interest for risk stratification and prevention. We studied the functional relevance of the 1...

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Bibliographic Details
Published in:	Human immunology Vol. 69; no. 6; pp. 338 - 343
Main Authors:	Härtel, Christoph, Rupp, Jan, Hoegemann, Anne, Bohler, Annegret, Spiegler, Juliane, von Otte, Sören, Röder, Kathrin, Schultz, Christian, Göpel, Wolfgang
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-06-2008
Subjects:	159C>T CD14 polymorphism Allergy and Immunology Cell Culture Techniques Communicable Diseases - blood Communicable Diseases - immunology Female Fetal Blood - cytology Fetal Blood - immunology Fetal Blood - metabolism Gene Frequency Genetic Predisposition to Disease Genotype Germany Humans Immunity, Innate - genetics Infant Infant, Newborn Innate immune system Interleukin-10 - blood Interleukin-10 - genetics Interleukin-10 - immunology Interleukin-6 Interleukin-6 - blood Interleukin-6 - genetics Interleukin-6 - immunology Lipopolysaccharide Receptors - blood Lipopolysaccharide Receptors - genetics Lipopolysaccharide Receptors - immunology Male Polymorphism, Single Nucleotide Tumor Necrosis Factor-alpha - blood Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - immunology Innate immune system 159C>T CD14 polymorphism Interleukin-6
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