Hypoxia-induced changes in tight junction permeability of brain capillary endothelial cells are associated with IL-1beta and nitric oxide

We examined whether hypoxia alone could produce changes in the permeability of brain capillary endothelial cells (EC) and whether a stimulation of hypoxic status alters the gene expression of occludin and glucose transporter 1 (GLUT1). Exposure of EC to hypoxia resulted in increased permeability, wi...

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Bibliographic Details
Published in:	Neurobiology of disease Vol. 17; no. 3; pp. 491 - 499
Main Authors:	Yamagata, Kazuo, Tagami, Motoki, Takenaga, Fumio, Yamori, Yukio, Itoh, Shingo
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-12-2004 Elsevier
Subjects:	Animals Brain - blood supply Capillaries - physiology Capillary endothelial cells Cell Hypoxia - physiology Cell Membrane Permeability - physiology Cells, Cultured Cerebrovascular Circulation - physiology Electrophysiology - methods Endothelium, Vascular - physiology Extracellular Space - physiology Hypoxia IL-1 Interleukin-1 - physiology NG-Nitroarginine Methyl Ester - pharmacology Nitric oxide Nitric Oxide - analysis Nitric Oxide - physiology Occludin Polymerase Chain Reaction Swine Tight junction Tight Junctions - drug effects Tight Junctions - physiology Hypoxia Tight junction Capillary endothelial cells IL-1 Nitric oxide Occludin
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