Bone Health in Glomerular Kidney Disease

• Published in: Current osteoporosis reports Vol. 17; no. 6; pp. 570 - 579
• Main Authors: Glenn, Dorey A., Denburg, Michelle R.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01-12-2019
• Subjects: Absorptiometry, Photon; Animals; Bone and Bones - diagnostic imaging; Bone and Bones - metabolism; Bone Density; Chronic Kidney Disease-Mineral and Bone Disorder - metabolism; Epidemiology; Glomerulonephritis - drug therapy; Glomerulonephritis - metabolism; Glucocorticoids - adverse effects; Humans; Inflammation - metabolism; Kidney and Bone (I Salusky and T Nickolas; Medicine; Medicine & Public Health; Orthopedics; Osteoporosis - chemically induced; Osteoporosis - diagnostic imaging; Osteoporosis - metabolism; Osteoporotic Fractures; Renal Insufficiency, Chronic - metabolism; Section Editors; Topical Collection on Kidney and Bone; Vitamin D - metabolism; Bone density; Fracture; Bone; Vitamin D; Glomerular
• ISSN: 1544-1873; 1544-2241
• DOI: 10.1007/s11914-019-00531-z

Purpose of Review
To summarize the literature regarding alterations in bone health in patients with glomerular kidney disease and highlight areas in need of additional investigation.
Recent Findings
There is mounting evidence that children and adults with glomerular conditions, with or without compromised kidney function, comprise a distinct subgroup of patients with unique risk factors for altered bone health.
Summary
Patients with glomerular kidney disease are exposed to both disease-related and treatment-related factors that affect bone structure and function. In addition to chronic kidney disease–related risk factors for impaired bone health, high rates of exposure to osteotoxic medications, varying degrees of systemic inflammation, and altered vitamin D metabolism may contribute to compromised bone health in individuals with glomerular disease. Further study is needed to better understand these risk factors and the complex interaction between the immune system and bone cells in glomerular disease.