Lessons from next-generation sequencing analysis in hematological malignancies

Next-generation sequencing has led to a revolution in the study of hematological malignancies with a substantial number of publications and discoveries in the last few years. Significant discoveries associated with disease diagnosis, risk stratification, clonal evolution and therapeutic intervention...

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Bibliographic Details
Published in:	Blood cancer journal (New York) Vol. 3; no. 7; p. e127
Main Authors:	Braggio, E, Egan, J B, Fonseca, R, Stewart, A K
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01-07-2013 Springer Nature B.V Nature Publishing Group
Subjects:	631/1647/514/2254 631/67/1990 Biomedical and Life Sciences Biomedicine Cancer Research Hematology Oncology Review RNA sequencing genome sequencing hematological malignancy clonal architecture
Online Access:	Get full text
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Summary:	Next-generation sequencing has led to a revolution in the study of hematological malignancies with a substantial number of publications and discoveries in the last few years. Significant discoveries associated with disease diagnosis, risk stratification, clonal evolution and therapeutic intervention have been generated by this powerful technology. As part of the post-genomic era, sequencing analysis will likely become part of routine clinical testing and the challenge will ultimately be successfully transitioning from gene discovery to preventive and therapeutic intervention as part of individualized medicine strategies. In this report, we review recent advances in the understanding of hematological malignancies derived through genome-wide sequence analysis.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work.
ISSN:	2044-5385 2044-5385
DOI:	10.1038/bcj.2013.26